ZA878835B - Cephalosporin derivatives and their crystalline derivatives - Google Patents

Cephalosporin derivatives and their crystalline derivatives

Info

Publication number
ZA878835B
ZA878835B ZA878835A ZA878835A ZA878835B ZA 878835 B ZA878835 B ZA 878835B ZA 878835 A ZA878835 A ZA 878835A ZA 878835 A ZA878835 A ZA 878835A ZA 878835 B ZA878835 B ZA 878835B
Authority
ZA
South Africa
Prior art keywords
derivatives
crystalline
cephalosporin
cephalosporin derivatives
crystalline derivatives
Prior art date
Application number
ZA878835A
Other languages
English (en)
Inventor
Kato Kazuo
Murakami Kimihiro
Mochizuki Hidenori
Mochida Ei
Original Assignee
Mochida Pharmaceutical Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co.,Ltd. filed Critical Mochida Pharmaceutical Co.,Ltd.
Publication of ZA878835B publication Critical patent/ZA878835B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ZA878835A 1986-11-25 1987-11-25 Cephalosporin derivatives and their crystalline derivatives ZA878835B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61280019A JPS63132893A (ja) 1986-11-25 1986-11-25 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤

Publications (1)

Publication Number Publication Date
ZA878835B true ZA878835B (en) 1988-05-25

Family

ID=17619166

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878835A ZA878835B (en) 1986-11-25 1987-11-25 Cephalosporin derivatives and their crystalline derivatives

Country Status (13)

Country Link
US (1) US4866055A (xx)
EP (1) EP0272487A1 (xx)
JP (1) JPS63132893A (xx)
KR (1) KR890700128A (xx)
AU (2) AU598607B2 (xx)
DK (1) DK416888D0 (xx)
FI (1) FI883496A (xx)
IL (1) IL84580A0 (xx)
NZ (1) NZ222670A (xx)
PH (1) PH24993A (xx)
WO (1) WO1988003924A1 (xx)
ZA (1) ZA878835B (xx)
ZW (1) ZW21787A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
FI883320A (fi) * 1987-08-07 1989-02-08 Sankei Yakuhin Kk --laktam, dess framstaellning och mellanprodukter foer dess framstaellning.
JPH0418056A (ja) * 1990-05-09 1992-01-22 Sanwa Kagaku Kenkyusho Co Ltd ポリイソプレン化合物及びその塩、これ等の製法並びにこれ等を有効成分とする消化性潰瘍治療剤
US5234920A (en) * 1990-08-23 1993-08-10 Bristol-Myers Squibb Company Antibiotic C-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
US5095012A (en) * 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
EP0544166A3 (en) * 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
DK0551034T3 (da) * 1991-12-12 2001-01-29 Hoechst Marion Roussel Inc Antibiotiske cephalosporiner med en i stilling 7 substitueret benzyloxyiminogruppe
IL105191A (en) * 1992-04-04 1998-08-16 Basf Ag Acids and aminooxymethylbenzoic acids and their preparation
KR100257129B1 (ko) * 1993-09-11 2000-05-15 성재갑 신규 세팔로스포린계 항생제 및 이의 제조방법
DE102004024010A1 (de) * 2004-05-14 2005-12-01 Bayer Chemicals Ag Verfahren zur Herstellung von Difluorbenzo-1,3-dioxol-5-carbonsäurederivaten
US8698184B2 (en) 2011-01-21 2014-04-15 Cree, Inc. Light emitting diodes with low junction temperature and solid state backlight components including light emitting diodes with low junction temperature

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE566543A (xx) * 1957-04-09
JPS503170B1 (xx) * 1970-06-11 1975-01-31
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
NZ189245A (en) * 1976-01-23 1979-12-11 Roussel Uclaf Substituted 2-(2-amino-4-thiazoyl)-2-hydroxyimino-acetic acid derivatives
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
US4082912A (en) * 1976-06-30 1978-04-04 Bristol-Myers Company Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters
US4104469A (en) * 1977-04-15 1978-08-01 Bristol-Myers Company 7-(Syn-α-alkoxy-iminofuryl)acetamido-3-(2-methyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
US4103085A (en) * 1977-02-24 1978-07-25 Bristol-Myers Company 7-(Syn-α-alkoxy-iminofurylacetamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2400519A1 (fr) * 1977-08-17 1979-03-16 Roussel Uclaf Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
AR231986A1 (es) * 1978-05-26 1985-04-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
EP0037380B1 (en) * 1980-03-28 1984-09-12 BIOCHEMIE Gesellschaft m.b.H. New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
US4316024A (en) * 1980-09-15 1982-02-16 Bristol-Myers Company Dioxo piperazine compounds
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
US4436912A (en) * 1981-09-08 1984-03-13 Eli Lilly And Company 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4526977A (en) * 1981-10-07 1985-07-02 American Home Products Corporation 2-(3-Amino-5-isoxazolyl)-2-oxyimino-acetic acids
US4594417A (en) * 1981-10-30 1986-06-10 Eli Lilly Company Crystalline antibiotic salt
DE3143537A1 (de) * 1981-11-03 1983-05-11 Hoechst Ag, 6230 Frankfurt Kristalline salze von cefodizim und verfahren zu ihrer herstellung
FR2517309A1 (fr) * 1981-12-01 1983-06-03 Sanofi Sa Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
JPS5946292A (ja) * 1982-09-09 1984-03-15 Otsuka Chem Co Ltd ２−置換セフエム誘導体の製造法
JPS5973575A (ja) * 1982-10-05 1984-04-25 Shionogi & Co Ltd プロピニルアミノイソオキサゾ−ル誘導体
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
JPS59155391A (ja) * 1983-02-22 1984-09-04 Tanabe Seiyaku Co Ltd 新規セファロスポリン誘導体
JPS6066987A (ja) * 1983-09-20 1985-04-17 Takeda Chem Ind Ltd 抗生物質ｔａν−５４７，その製造法および微生物
US4600773A (en) * 1983-12-01 1986-07-15 Eli Lilly And Company Crystalline cephalexin hydrochloride monohydrate
JPS61126089A (ja) * 1984-11-26 1986-06-13 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体、その製法およびそれらを含有する抗菌剤
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
AU586229B2 (en) * 1985-04-01 1989-07-06 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives

Also Published As

Publication number Publication date
PH24993A (en) 1990-12-26
JPS63132893A (ja) 1988-06-04
DK416888A (da) 1988-07-25
FI883496A0 (fi) 1988-07-25
EP0272487A1 (en) 1988-06-29
FI883496A (fi) 1988-07-25
KR890700128A (ko) 1989-03-02
WO1988003924A1 (en) 1988-06-02
ZW21787A1 (en) 1988-09-07
AU8163187A (en) 1988-05-26
DK416888D0 (da) 1988-07-25
AU598607B2 (en) 1990-06-28
IL84580A0 (en) 1988-04-29
NZ222670A (en) 1990-08-28
US4866055A (en) 1989-09-12
AU6316790A (en) 1991-03-28

Similar Documents

Publication Publication Date Title
AU7162487A (en) Cephalosporin derivatives
EP0186187A3 (en) Cephalosporin derivatives
EP0182210A3 (en) Cephalosporin derivatives
AU7591787A (en) Cephalosporin derivatives
ZW21787A1 (en) Cephalosporin derivatives and their crystalline derivatives
AU6450990A (en) Cephalosporin derivatives
IL89679A0 (en) Cephalosporin derivatives and processes for their preparation
GB8715337D0 (en) Preparing cephalosporin derivatives
PH23442A (en) Cephalosporin derivatives and salts thereof
GB8724272D0 (en) Thiadiazole derivatives
IL74822A (en) Cephalosporin derivatives and salts thereof and their preparation
IL83193A0 (en) Cephalosporins and derivatives
PH21201A (en) Cephalosporin derivatives and salts thereof
ZA875511B (en) Cephalosporins and derivatives
DE3573920D1 (en) Cephalosporin derivatives
IE862959L (en) Cephalosporin derivatives
IE861673L (en) Cephalosporin derivatives
IE861825L (en) Cephalosporin derivatives
IE862136L (en) Cephalosporin derivatives
IE872021L (en) Cephalosporins and derivatives
GB8706874D0 (en) Cephalosporin derivatives
IE881066L (en) Cephalosporin derivatives
IE880625L (en) Cephalosporin derivatives
IE882470L (en) Cephalosporin derivatives
ZA862347B (en) Cephalosporin derivatives