ZA878083B - Process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof - Google Patents

Process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof

Info

Publication number
ZA878083B
ZA878083B ZA878083A ZA878083A ZA878083B ZA 878083 B ZA878083 B ZA 878083B ZA 878083 A ZA878083 A ZA 878083A ZA 878083 A ZA878083 A ZA 878083A ZA 878083 B ZA878083 B ZA 878083B
Authority
ZA
South Africa
Prior art keywords
guanidino
thiazole
imidazolyl
pentyl
methyl
Prior art date
Application number
ZA878083A
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
John Meldrum Allen Douglas
William Michael Snyder
Michael Snyder William
Berkeley Wendell Cue Jr
Wendell Cue Berkeley Jr
Stanley Walter Walinsky
Walter Walinsky Stanley
Paul David Hill
David Hill Paul
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA878083B publication Critical patent/ZA878083B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA878083A 1986-10-29 1987-10-28 Process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof ZA878083B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1986/002307 WO1988003140A1 (en) 1986-10-29 1986-10-29 Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate

Publications (1)

Publication Number Publication Date
ZA878083B true ZA878083B (en) 1989-06-28

Family

ID=22195693

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878083A ZA878083B (en) 1986-10-29 1987-10-28 Process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof

Country Status (11)

Country Link
US (1) US4997949A (de)
JP (1) JPS63122680A (de)
AU (1) AU579775B2 (de)
CA (1) CA1313378C (de)
DD (2) DD262659A5 (de)
FI (1) FI89918C (de)
NO (1) NO170417C (de)
PH (1) PH23922A (de)
RU (1) RU1779252C (de)
WO (1) WO1988003140A1 (de)
ZA (1) ZA878083B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387597A (en) * 1991-02-25 1995-02-07 Pfizer Inc. Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole
NO329085B1 (no) * 2008-01-31 2010-08-16 Sorbwater Technology As Fremgangsmate og apparat for separasjon av fluidfaser, samt anvendelser derav

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN163170B (de) * 1980-10-14 1988-08-20 Pfizer
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
JPS6191122A (ja) * 1984-10-11 1986-05-09 フアイザー・インコーポレーテツド ２―グアニジノ―４―（２―メチル―４―イミダゾリル）チアゾール類からなる慢性関節リウマチ治療用組成物
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide

Also Published As

Publication number Publication date
WO1988003140A1 (en) 1988-05-05
PH23922A (en) 1990-01-23
NO882861D0 (no) 1988-06-28
DD262659A5 (de) 1988-12-07
US4997949A (en) 1991-03-05
FI892034A (fi) 1989-04-28
RU1779252C (ru) 1992-11-30
FI89918B (fi) 1993-08-31
JPS63122680A (ja) 1988-05-26
CA1313378C (en) 1993-02-02
AU579775B2 (en) 1988-12-08
AU8042887A (en) 1988-05-05
DD272851A5 (de) 1989-10-25
FI89918C (fi) 1993-12-10
NO170417B (no) 1992-07-06
FI892034A0 (fi) 1989-04-28
NO170417C (no) 1992-10-14
NO882861L (no) 1988-06-28
JPH0513952B2 (de) 1993-02-23

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