ZA862794B - Leukotriene antagonists - Google Patents

Leukotriene antagonists

Info

Publication number
ZA862794B
ZA862794B ZA862794A ZA862794A ZA862794B ZA 862794 B ZA862794 B ZA 862794B ZA 862794 A ZA862794 A ZA 862794A ZA 862794 A ZA862794 A ZA 862794A ZA 862794 B ZA862794 B ZA 862794B
Authority
ZA
South Africa
Prior art keywords
leukotriene antagonists
co2r10
intermediates
fluoro
methoxy
Prior art date
Application number
ZA862794A
Other languages
English (en)
Inventor
John Gerald Gleason
Ralph Floyd Hall
Thomas Wen-Fu Ku
Carl David Perchonock
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZA862794B publication Critical patent/ZA862794B/xx

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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
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    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
ZA862794A 1985-04-19 1986-04-15 Leukotriene antagonists ZA862794B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72526485A 1985-04-19 1985-04-19

Publications (1)

Publication Number Publication Date
ZA862794B true ZA862794B (en) 1987-06-24

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ID=24913819

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA862794A ZA862794B (en) 1985-04-19 1986-04-15 Leukotriene antagonists

Country Status (23)

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EP (2) EP0202759B1 (zh)
JP (3) JPS61249958A (zh)
KR (1) KR950003335B1 (zh)
CN (2) CN1008091B (zh)
AT (2) ATE90330T1 (zh)
AU (3) AU595193B2 (zh)
CA (2) CA1276937C (zh)
CY (1) CY1733A (zh)
DE (2) DE3688561T2 (zh)
DK (1) DK176586A (zh)
EG (1) EG18226A (zh)
ES (1) ES8801175A1 (zh)
FI (1) FI88293C (zh)
GR (1) GR860993B (zh)
HK (2) HK106893A (zh)
HU (2) HU198918B (zh)
IE (1) IE58958B1 (zh)
IL (1) IL78495A (zh)
MY (1) MY102219A (zh)
NO (1) NO164414C (zh)
PH (1) PH23745A (zh)
PT (1) PT82394B (zh)
ZA (1) ZA862794B (zh)

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US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
AU595193B2 (en) 1985-04-19 1990-03-29 Smithkline Beckman Corporation Thio substituted acidic derivatives
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
PT94376A (pt) * 1989-06-14 1991-03-20 Smithkline Beecham Corp Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby
EP0480060B1 (en) * 1990-04-26 1996-10-23 Senju Pharmaceutical Co., Ltd. S-(lower fatty acid)-substituted glutathione derivative
CA2081462A1 (en) * 1990-05-01 1991-11-02 James S. Frazee Five-membered ring alkanoic acid leukotriene antagonists
JPH05506662A (ja) * 1990-05-01 1993-09-30 スミスクライン・ビーチャム・コーポレイション ３―ナフチル―３―カルボキシアルキルチオまたはオキシ置換アルカン酸ロイコトリエン拮抗剤
ATE127784T1 (de) * 1990-08-01 1995-09-15 Smithkline Beecham Corp Verfahren und zwischenprodukte für die herstellung von 2-hydroxy-3-sulfido-3- phenylpropansäuren.
DE102005051788B3 (de) 2005-10-28 2007-05-16 Novelis Deutschland Gmbh Verfahren und Vorrichtung zur Herstellung eines Wickelrohres

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CA1090811A (en) * 1976-10-18 1980-12-02 Genichi Tsuchihashi .alpha.-THIO-ALKANOIC ACID DERIVATIVES
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US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
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GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
NO160576C (no) * 1984-01-19 1989-05-03 Smithkline Beckman Corp Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive karboksylsyrederivater.
EP0161172A1 (fr) * 1984-04-19 1985-11-13 Synthelabo Dérivés d'acide n-(phenylmethylthio-3 oxo-1 propyl)-aminoacétique, leur préparation et leur application en thérapeutique
AU595193B2 (en) 1985-04-19 1990-03-29 Smithkline Beckman Corporation Thio substituted acidic derivatives

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AU7929187A (en) 1988-03-17
JPH0643358B2 (ja) 1994-06-08
PT82394A (en) 1986-05-01
DE3672130D1 (de) 1990-07-26
IL78495A0 (en) 1986-08-31
AU5789790A (en) 1990-12-13
EG18226A (en) 1992-10-30
IE861025L (en) 1986-10-19
NO164414B (no) 1990-06-25
ATE90330T1 (de) 1993-06-15
HK106893A (en) 1993-10-15
EP0358240B1 (en) 1993-06-09
EP0202759A2 (en) 1986-11-26
JPS61249958A (ja) 1986-11-07
ES554135A0 (es) 1987-12-16
CY1733A (en) 1994-05-06
EP0358240A2 (en) 1990-03-14
KR950003335B1 (ko) 1995-04-10
CN1040586A (zh) 1990-03-21
PT82394B (pt) 1988-08-17
MY102219A (en) 1992-05-15
CN1025564C (zh) 1994-08-03
AU595193B2 (en) 1990-03-29
DK176586D0 (da) 1986-04-17
CN86102482A (zh) 1987-02-04
ATE53991T1 (de) 1990-07-15
JPH05194460A (ja) 1993-08-03
HU196365B (en) 1988-11-28
FI88293C (fi) 1993-04-26
FI861635A0 (fi) 1986-04-17
CA1276937C (en) 1990-11-27
NO164414C (no) 1990-10-03
EP0202759B1 (en) 1990-06-20
EP0358240A3 (en) 1990-06-20
HUT43812A (en) 1987-12-28
HK1006838A1 (en) 1999-03-19
DK176586A (da) 1986-10-20
JPH0692380B2 (ja) 1994-11-16
FI88293B (fi) 1993-01-15
AU5605086A (en) 1986-10-23
FI861635A (fi) 1986-10-20
ES8801175A1 (es) 1987-12-16
DE3688561T2 (de) 1993-09-23
JPH0474348B2 (zh) 1992-11-26
IL78495A (en) 1993-01-14
EP0202759A3 (en) 1988-09-07
DE3688561D1 (de) 1993-07-15
HU198918B (en) 1989-12-28
JPH05194302A (ja) 1993-08-03
AU604060B2 (en) 1990-12-06
CN1008091B (zh) 1990-05-23
KR860008131A (ko) 1986-11-12
NO861534L (no) 1986-10-20
CA1314899C (en) 1993-03-23
IE58958B1 (en) 1993-12-01
PH23745A (en) 1989-11-03
GR860993B (en) 1986-08-12

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