PH23745A - Leukotriene antagonists - Google Patents

Leukotriene antagonists

Info

Publication number
PH23745A
PH23745A PH33678A PH33678A PH23745A PH 23745 A PH23745 A PH 23745A PH 33678 A PH33678 A PH 33678A PH 33678 A PH33678 A PH 33678A PH 23745 A PH23745 A PH 23745A
Authority
PH
Philippines
Prior art keywords
leukotriene antagonists
co2r10
intermediates
fluoro
methoxy
Prior art date
Application number
PH33678A
Other languages
English (en)
Inventor
John Gerald Gleason
Ralph Floyd Hall
Thomas Wen-Fu Ku
Carl David Perchonock
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PH23745A publication Critical patent/PH23745A/en

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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C47/542—Alkylated benzaldehydes
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    • C07C47/546—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings polycyclic
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D303/02—Compounds containing oxirane rings
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    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/14—The ring being saturated
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    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
PH33678A 1985-04-19 1986-04-18 Leukotriene antagonists PH23745A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72526485A 1985-04-19 1985-04-19

Publications (1)

Publication Number Publication Date
PH23745A true PH23745A (en) 1989-11-03

Family

ID=24913819

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33678A PH23745A (en) 1985-04-19 1986-04-18 Leukotriene antagonists

Country Status (23)

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EP (2) EP0202759B1 (zh)
JP (3) JPS61249958A (zh)
KR (1) KR950003335B1 (zh)
CN (2) CN1008091B (zh)
AT (2) ATE53991T1 (zh)
AU (3) AU595193B2 (zh)
CA (2) CA1276937C (zh)
CY (1) CY1733A (zh)
DE (2) DE3688561T2 (zh)
DK (1) DK176586A (zh)
EG (1) EG18226A (zh)
ES (1) ES8801175A1 (zh)
FI (1) FI88293C (zh)
GR (1) GR860993B (zh)
HK (2) HK106893A (zh)
HU (2) HU198918B (zh)
IE (1) IE58958B1 (zh)
IL (1) IL78495A (zh)
MY (1) MY102219A (zh)
NO (1) NO164414C (zh)
PH (1) PH23745A (zh)
PT (1) PT82394B (zh)
ZA (1) ZA862794B (zh)

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US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
DE3688561T2 (de) 1985-04-19 1993-09-23 Smithkline Beckman Corp Zwischenprodukte fuer die herstellung von leukotrien-antagonisten.
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
PT94376A (pt) * 1989-06-14 1991-03-20 Smithkline Beecham Corp Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby
DE69123428T2 (de) * 1990-04-26 1997-05-15 Senju Pharma Co Inhibitor von lebererkrankungen
WO1991016889A1 (en) * 1990-05-01 1991-11-14 Smithkline Beecham Corporation Five-membered ring alkanoic acid leukotriene antagonists
EP0527175A4 (en) * 1990-05-01 1993-05-05 Smithkline Beecham Corporation 3-naphthyl-3-carboxyalkylthio or oxy substituted alkanoic acid leukotriene antagonists
CN1059521A (zh) * 1990-08-01 1992-03-18 史密丝克莱恩比彻姆公司 制备2-羟基-3-硫醚-3苯基丙酸的方法和中间体
DE102005051788B3 (de) 2005-10-28 2007-05-16 Novelis Deutschland Gmbh Verfahren und Vorrichtung zur Herstellung eines Wickelrohres

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GB1577550A (en) * 1976-10-18 1980-10-22 Sagami Chem Res -thio-alkanoic acid derivatives
FR2468362A1 (fr) * 1978-07-12 1981-05-08 Oreal Compositions cosmetiques a base de dithioethers pour le traitement de l'etat gras des cheveux et de la peau, nouveaux composes et leur procede d'obtention
NZ194844A (en) * 1979-09-05 1983-07-29 Glaxo Group Ltd Phenoxyalkoxyphenyl derivatives and pharmaceutical compositions
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
DE3360677D1 (en) * 1982-11-11 1985-10-03 Beecham Group Plc Arachidonic acid analogues, processes for their preparation and their use in medicine
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
CA1243035A (en) * 1984-01-19 1988-10-11 John G. Gleason Leukotriene antagonists
EP0161172A1 (fr) * 1984-04-19 1985-11-13 Synthelabo Dérivés d'acide n-(phenylmethylthio-3 oxo-1 propyl)-aminoacétique, leur préparation et leur application en thérapeutique
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CN1025564C (zh) 1994-08-03
AU5789790A (en) 1990-12-13
ZA862794B (en) 1987-06-24
JPH05194460A (ja) 1993-08-03
NO861534L (no) 1986-10-20
NO164414C (no) 1990-10-03
CA1314899C (en) 1993-03-23
DE3672130D1 (de) 1990-07-26
ATE90330T1 (de) 1993-06-15
EP0202759B1 (en) 1990-06-20
FI88293B (fi) 1993-01-15
CN1008091B (zh) 1990-05-23
IE58958B1 (en) 1993-12-01
EP0202759A2 (en) 1986-11-26
DK176586A (da) 1986-10-20
JPH0692380B2 (ja) 1994-11-16
AU604060B2 (en) 1990-12-06
HU196365B (en) 1988-11-28
JPH0643358B2 (ja) 1994-06-08
MY102219A (en) 1992-05-15
ES8801175A1 (es) 1987-12-16
FI861635A (fi) 1986-10-20
EP0358240A2 (en) 1990-03-14
JPH05194302A (ja) 1993-08-03
CN86102482A (zh) 1987-02-04
DE3688561T2 (de) 1993-09-23
JPS61249958A (ja) 1986-11-07
KR950003335B1 (ko) 1995-04-10
CA1276937C (en) 1990-11-27
DE3688561D1 (de) 1993-07-15
AU595193B2 (en) 1990-03-29
AU7929187A (en) 1988-03-17
HU198918B (en) 1989-12-28
HK106893A (en) 1993-10-15
IL78495A (en) 1993-01-14
IE861025L (en) 1986-10-19
EP0202759A3 (en) 1988-09-07
PT82394B (pt) 1988-08-17
JPH0474348B2 (zh) 1992-11-26
ATE53991T1 (de) 1990-07-15
GR860993B (en) 1986-08-12
AU5605086A (en) 1986-10-23
HUT43812A (en) 1987-12-28
FI861635A0 (fi) 1986-04-17
CN1040586A (zh) 1990-03-21
EP0358240A3 (en) 1990-06-20
DK176586D0 (da) 1986-04-17
CY1733A (en) 1994-05-06
EG18226A (en) 1992-10-30
PT82394A (en) 1986-05-01
IL78495A0 (en) 1986-08-31
EP0358240B1 (en) 1993-06-09
NO164414B (no) 1990-06-25
HK1006838A1 (en) 1999-03-19
ES554135A0 (es) 1987-12-16
KR860008131A (ko) 1986-11-12
FI88293C (fi) 1993-04-26

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