DK176586A - Leukotrienantagonister - Google Patents

Leukotrienantagonister Download PDF

Info

Publication number
DK176586A
DK176586A DK176586A DK176586A DK176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A
Authority
DK
Denmark
Prior art keywords
leukotriene antagonists
hydrogen
co2r10
alkyl
methoxy
Prior art date
Application number
DK176586A
Other languages
Danish (da)
English (en)
Other versions
DK176586D0 (da
Inventor
John Gerald Gleason
Ralph Floyd Hall
Thomas Wen-Fu Ku
Carl David Perchonock
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK176586D0 publication Critical patent/DK176586D0/da
Publication of DK176586A publication Critical patent/DK176586A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/542—Alkylated benzaldehydes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/546—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
DK176586A 1985-04-19 1986-04-17 Leukotrienantagonister DK176586A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72526485A 1985-04-19 1985-04-19
US72526485 1985-04-19

Publications (2)

Publication Number Publication Date
DK176586D0 DK176586D0 (da) 1986-04-17
DK176586A true DK176586A (da) 1986-10-20

Family

ID=24913819

Family Applications (1)

Application Number Title Priority Date Filing Date
DK176586A DK176586A (da) 1985-04-19 1986-04-17 Leukotrienantagonister

Country Status (23)

Country Link
EP (2) EP0202759B1 (zh)
JP (3) JPS61249958A (zh)
KR (1) KR950003335B1 (zh)
CN (2) CN1008091B (zh)
AT (2) ATE90330T1 (zh)
AU (3) AU595193B2 (zh)
CA (2) CA1276937C (zh)
CY (1) CY1733A (zh)
DE (2) DE3688561T2 (zh)
DK (1) DK176586A (zh)
EG (1) EG18226A (zh)
ES (1) ES8801175A1 (zh)
FI (1) FI88293C (zh)
GR (1) GR860993B (zh)
HK (2) HK106893A (zh)
HU (2) HU198918B (zh)
IE (1) IE58958B1 (zh)
IL (1) IL78495A (zh)
MY (1) MY102219A (zh)
NO (1) NO164414C (zh)
PH (1) PH23745A (zh)
PT (1) PT82394B (zh)
ZA (1) ZA862794B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
AU595193B2 (en) 1985-04-19 1990-03-29 Smithkline Beckman Corporation Thio substituted acidic derivatives
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
PT94376A (pt) * 1989-06-14 1991-03-20 Smithkline Beecham Corp Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby
EP0480060B1 (en) * 1990-04-26 1996-10-23 Senju Pharmaceutical Co., Ltd. S-(lower fatty acid)-substituted glutathione derivative
CA2081462A1 (en) * 1990-05-01 1991-11-02 James S. Frazee Five-membered ring alkanoic acid leukotriene antagonists
JPH05506662A (ja) * 1990-05-01 1993-09-30 スミスクライン・ビーチャム・コーポレイション ３―ナフチル―３―カルボキシアルキルチオまたはオキシ置換アルカン酸ロイコトリエン拮抗剤
ATE127784T1 (de) * 1990-08-01 1995-09-15 Smithkline Beecham Corp Verfahren und zwischenprodukte für die herstellung von 2-hydroxy-3-sulfido-3- phenylpropansäuren.
DE102005051788B3 (de) 2005-10-28 2007-05-16 Novelis Deutschland Gmbh Verfahren und Vorrichtung zur Herstellung eines Wickelrohres

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1090811A (en) * 1976-10-18 1980-12-02 Genichi Tsuchihashi .alpha.-THIO-ALKANOIC ACID DERIVATIVES
FR2468362A1 (fr) * 1978-07-12 1981-05-08 Oreal Compositions cosmetiques a base de dithioethers pour le traitement de l'etat gras des cheveux et de la peau, nouveaux composes et leur procede d'obtention
DE3068213D1 (en) * 1979-09-05 1984-07-19 Glaxo Group Ltd Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
DE3360677D1 (en) * 1982-11-11 1985-10-03 Beecham Group Plc Arachidonic acid analogues, processes for their preparation and their use in medicine
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
NO160576C (no) * 1984-01-19 1989-05-03 Smithkline Beckman Corp Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive karboksylsyrederivater.
EP0161172A1 (fr) * 1984-04-19 1985-11-13 Synthelabo Dérivés d'acide n-(phenylmethylthio-3 oxo-1 propyl)-aminoacétique, leur préparation et leur application en thérapeutique
AU595193B2 (en) 1985-04-19 1990-03-29 Smithkline Beckman Corporation Thio substituted acidic derivatives

Also Published As

Publication number Publication date
AU7929187A (en) 1988-03-17
JPH0643358B2 (ja) 1994-06-08
PT82394A (en) 1986-05-01
DE3672130D1 (de) 1990-07-26
IL78495A0 (en) 1986-08-31
AU5789790A (en) 1990-12-13
EG18226A (en) 1992-10-30
IE861025L (en) 1986-10-19
NO164414B (no) 1990-06-25
ATE90330T1 (de) 1993-06-15
HK106893A (en) 1993-10-15
EP0358240B1 (en) 1993-06-09
EP0202759A2 (en) 1986-11-26
JPS61249958A (ja) 1986-11-07
ES554135A0 (es) 1987-12-16
CY1733A (en) 1994-05-06
EP0358240A2 (en) 1990-03-14
KR950003335B1 (ko) 1995-04-10
CN1040586A (zh) 1990-03-21
PT82394B (pt) 1988-08-17
MY102219A (en) 1992-05-15
CN1025564C (zh) 1994-08-03
AU595193B2 (en) 1990-03-29
DK176586D0 (da) 1986-04-17
CN86102482A (zh) 1987-02-04
ATE53991T1 (de) 1990-07-15
JPH05194460A (ja) 1993-08-03
HU196365B (en) 1988-11-28
FI88293C (fi) 1993-04-26
FI861635A0 (fi) 1986-04-17
CA1276937C (en) 1990-11-27
NO164414C (no) 1990-10-03
EP0202759B1 (en) 1990-06-20
EP0358240A3 (en) 1990-06-20
HUT43812A (en) 1987-12-28
HK1006838A1 (en) 1999-03-19
JPH0692380B2 (ja) 1994-11-16
FI88293B (fi) 1993-01-15
AU5605086A (en) 1986-10-23
FI861635A (fi) 1986-10-20
ES8801175A1 (es) 1987-12-16
DE3688561T2 (de) 1993-09-23
JPH0474348B2 (zh) 1992-11-26
IL78495A (en) 1993-01-14
EP0202759A3 (en) 1988-09-07
DE3688561D1 (de) 1993-07-15
HU198918B (en) 1989-12-28
JPH05194302A (ja) 1993-08-03
ZA862794B (en) 1987-06-24
AU604060B2 (en) 1990-12-06
CN1008091B (zh) 1990-05-23
KR860008131A (ko) 1986-11-12
NO861534L (no) 1986-10-20
CA1314899C (en) 1993-03-23
IE58958B1 (en) 1993-12-01
PH23745A (en) 1989-11-03
GR860993B (en) 1986-08-12

Similar Documents

Publication Publication Date Title
DK176586A (da) Leukotrienantagonister
NZ507144A (en) Benzamide derivatives useful for the treatment of diseases mediated by cytokines
NO822882L (no) Fremgangsmaate ved fremstilling av naftalener og benzokondenserte hetrocykliske forbindelser
WO2002049628A3 (en) Methods of treating anxiety disorders
ES2068333T3 (es) Metodo para preparar unos peptidos y su uso en terapia.
DE50301636D1 (de) Neue kupplerkomponenten
DK187186A (da) N-indolylethyl-sulfonsyreamider, deres fremstilling og anvendelse
NO920833L (no) Substituerte ureaforbindelser og bearbeiding og bruk av disse
ES2054304T3 (es) Feniletanolaminometiltetralinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
DK0579833T3 (da) Ethanolaminderivater med anti-pollakisuria-virkning
CA1272733C (en) Compositions for treating glaucoma
RU96114993A (ru) Производные n-замещенного 3-азабицикло[3.2.0]гептана
ES2029160A6 (es) Procedimiento para la preparacion de nuevas azetidinas.
DK0797437T3 (da) Immunterapeutiske imider/amider samt anvendelse deraf til at reducere niveauer af TNFalfa
ES8601850A1 (es) Un procedimiento para preparar derivados de ciclobutano
DK218083A (da) Aminoalkadien-derivater, deres fremstilling og anvendelse
FI963995A (fi) Atsolonien helikobakteeria vastustavat esteri- ja karbamaattijohdannaiset
HU9503689D0 (en) Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
RU96115134A (ru) Соединение 6-(2-имидазолиниламино)хинолина, пригодные в качестве агонистов альфа-2-адреноцепторов
EP0230018A3 (en) Pyrethroide, process for their preparation and their use in combatting parasites as well as precursors for the preparation of these pyrethroids
DK158729C (da) N-(3-trifluormethylphenyl)-n'-propargylpiperazin, farmaceutiske praeparater, der indeholder det, dets anvendelse, samt en fremgangsmaade til fremstilling af et farmaceutisk praeparat
PH24046A (en) Derivatives of n-(2-pyrrolidinylmethyl)-benzamide and pharmaceutical preparation containing them
DK356287A (da) 2,6-piperazindionderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
RU93004471A (ru) Пиперидилокси- и хинуклидинилокси-изоксазоловые производные и фармацевтическая композиция на их основе
ES2084485T3 (es) Procedimiento para la preparacion de amino-2 nitro-7 benzotiazoles.

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment