NO861534L - Fremgangsmaate for fremstilling av farmasoeytisk aktive leukotrien-antagonister. - Google Patents

Fremgangsmaate for fremstilling av farmasoeytisk aktive leukotrien-antagonister.

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Publication number
NO861534L
NO861534L NO861534A NO861534A NO861534L NO 861534 L NO861534 L NO 861534L NO 861534 A NO861534 A NO 861534A NO 861534 A NO861534 A NO 861534A NO 861534 L NO861534 L NO 861534L
Authority
NO
Norway
Prior art keywords
preparation
pharmasoeytic
procedure
active
antagonists
Prior art date
Application number
NO861534A
Other languages
English (en)
Other versions
NO164414C (no
NO164414B (no
Inventor
John Gerald Gleason
Ralph Floyd Hall
Thomas Wen-Fu Ku
Carl David Perchonock
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of NO861534L publication Critical patent/NO861534L/no
Publication of NO164414B publication Critical patent/NO164414B/no
Publication of NO164414C publication Critical patent/NO164414C/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
NO861534A 1985-04-19 1986-04-18 Analogifremgangsmaate for fremstilling av terapeutisk aktive leukotrien-antagonister. NO164414C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72526485A 1985-04-19 1985-04-19

Publications (3)

Publication Number Publication Date
NO861534L true NO861534L (no) 1986-10-20
NO164414B NO164414B (no) 1990-06-25
NO164414C NO164414C (no) 1990-10-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO861534A NO164414C (no) 1985-04-19 1986-04-18 Analogifremgangsmaate for fremstilling av terapeutisk aktive leukotrien-antagonister.

Country Status (23)

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EP (2) EP0202759B1 (no)
JP (3) JPS61249958A (no)
KR (1) KR950003335B1 (no)
CN (2) CN1008091B (no)
AT (2) ATE90330T1 (no)
AU (3) AU595193B2 (no)
CA (2) CA1276937C (no)
CY (1) CY1733A (no)
DE (2) DE3672130D1 (no)
DK (1) DK176586A (no)
EG (1) EG18226A (no)
ES (1) ES8801175A1 (no)
FI (1) FI88293C (no)
GR (1) GR860993B (no)
HK (2) HK106893A (no)
HU (2) HU196365B (no)
IE (1) IE58958B1 (no)
IL (1) IL78495A (no)
MY (1) MY102219A (no)
NO (1) NO164414C (no)
PH (1) PH23745A (no)
PT (1) PT82394B (no)
ZA (1) ZA862794B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
EP0202759B1 (en) 1985-04-19 1990-06-20 Smithkline Beecham Corporation Leukotriene antagonists
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby
PT94376A (pt) * 1989-06-14 1991-03-20 Smithkline Beecham Corp Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
US5232913A (en) * 1990-04-26 1993-08-03 Senju Pharmaceutical Co., Ltd. Antihepatopathic composition
AU7902991A (en) * 1990-05-01 1991-11-27 Smithkline Beecham Corporation Five-membered ring alkanoic acid leukotriene antagonists
JPH05506662A (ja) * 1990-05-01 1993-09-30 スミスクライン・ビーチャム・コーポレイション ３―ナフチル―３―カルボキシアルキルチオまたはオキシ置換アルカン酸ロイコトリエン拮抗剤
HU9401975D0 (en) * 1990-08-01 1994-09-28 Smithkline Beecham Corp New intermediates for producing 2 -hydroxy-3-sulfido-3-phenyl-propionic acids
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JPH0643358B2 (ja) 1994-06-08
IE861025L (en) 1986-10-19
KR950003335B1 (ko) 1995-04-10
HU196365B (en) 1988-11-28
ZA862794B (en) 1987-06-24
CN1040586A (zh) 1990-03-21
CN86102482A (zh) 1987-02-04
ES554135A0 (es) 1987-12-16
AU604060B2 (en) 1990-12-06
CY1733A (en) 1994-05-06
NO164414C (no) 1990-10-03
CN1008091B (zh) 1990-05-23
DK176586A (da) 1986-10-20
CA1314899C (en) 1993-03-23
KR860008131A (ko) 1986-11-12
PH23745A (en) 1989-11-03
FI88293C (fi) 1993-04-26
DK176586D0 (da) 1986-04-17
EP0202759B1 (en) 1990-06-20
MY102219A (en) 1992-05-15
HK1006838A1 (en) 1999-03-19
DE3688561D1 (de) 1993-07-15
FI88293B (fi) 1993-01-15
IL78495A0 (en) 1986-08-31
NO164414B (no) 1990-06-25
JPS61249958A (ja) 1986-11-07
ATE53991T1 (de) 1990-07-15
EP0358240A2 (en) 1990-03-14
AU595193B2 (en) 1990-03-29
HK106893A (en) 1993-10-15
HUT43812A (en) 1987-12-28
JPH05194460A (ja) 1993-08-03
JPH0692380B2 (ja) 1994-11-16
JPH05194302A (ja) 1993-08-03
EP0202759A2 (en) 1986-11-26
EG18226A (en) 1992-10-30
EP0202759A3 (en) 1988-09-07
DE3672130D1 (de) 1990-07-26
EP0358240B1 (en) 1993-06-09
AU5605086A (en) 1986-10-23
JPH0474348B2 (no) 1992-11-26
PT82394B (pt) 1988-08-17
EP0358240A3 (en) 1990-06-20
FI861635A (fi) 1986-10-20
AU7929187A (en) 1988-03-17
HU198918B (en) 1989-12-28
AU5789790A (en) 1990-12-13
PT82394A (en) 1986-05-01
DE3688561T2 (de) 1993-09-23
IL78495A (en) 1993-01-14
ATE90330T1 (de) 1993-06-15
CN1025564C (zh) 1994-08-03
IE58958B1 (en) 1993-12-01
GR860993B (en) 1986-08-12
CA1276937C (en) 1990-11-27
ES8801175A1 (es) 1987-12-16
FI861635A0 (fi) 1986-04-17

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