ZA842800B - Ultrasound contrast agent containing microparticles and gas micro-bubbles - Google Patents

Ultrasound contrast agent containing microparticles and gas micro-bubbles

Info

Publication number
ZA842800B
ZA842800B ZA842800A ZA842800A ZA842800B ZA 842800 B ZA842800 B ZA 842800B ZA 842800 A ZA842800 A ZA 842800A ZA 842800 A ZA842800 A ZA 842800A ZA 842800 B ZA842800 B ZA 842800B
Authority
ZA
South Africa
Prior art keywords
bubbles
contrast agent
agent containing
containing microparticles
ultrasound contrast
Prior art date
Application number
ZA842800A
Other languages
English (en)
Inventor
Jurgen Hilmann
Ingfried Zimmermann
Lothar Lange
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA842800B publication Critical patent/ZA842800B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22089—Gas-bubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
ZA842800A 1983-04-15 1984-04-13 Ultrasound contrast agent containing microparticles and gas micro-bubbles ZA842800B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3313947A DE3313947A1 (de) 1983-04-15 1983-04-15 Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel

Publications (1)

Publication Number Publication Date
ZA842800B true ZA842800B (en) 1984-11-28

Family

ID=6196666

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA842800A ZA842800B (en) 1983-04-15 1984-04-13 Ultrasound contrast agent containing microparticles and gas micro-bubbles

Country Status (12)

Country Link
EP (1) EP0123235B1 (fr)
JP (1) JPS59205329A (fr)
AT (1) ATE36959T1 (fr)
AU (1) AU569072B2 (fr)
CA (1) CA1232837A (fr)
DE (2) DE3313947A1 (fr)
DK (1) DK165622C (fr)
FI (1) FI81265C (fr)
IE (1) IE57197B1 (fr)
NO (1) NO163669C (fr)
NZ (1) NZ207854A (fr)
ZA (1) ZA842800B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908610A (en) * 1992-11-02 1999-06-01 Bracco International B.V. Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography
US6585955B1 (en) 1990-04-02 2003-07-01 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7033574B1 (en) 1990-04-02 2006-04-25 Bracco International B.V. Stable microbubbles suspensions injectable into living organisms

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US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
DE3741199A1 (de) * 1987-12-02 1989-08-17 Schering Ag Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
DE3803972A1 (de) * 1988-02-05 1989-08-10 Schering Ag Ultraschallkontrastmittel
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
IE66912B1 (en) * 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
DE3803971C2 (de) * 1988-02-05 1997-09-18 Schering Ag Ultraschallkontrastmittel
FR2643252B1 (fr) * 1989-02-21 1991-06-07 Technomed Int Sa Appareil de destruction selective de cellules incluant les tissus mous et les os a l'interieur du corps d'un etre vivant par implosion de bulles de gaz
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
ES2074725T3 (es) * 1990-10-05 1995-09-16 Bracco Int Bv Metodo para la preparacion de suspensiones estables de microesferas huecas llenas de gas adecuadas para ecografia ultrasonica.
US5558857A (en) † 1991-06-03 1996-09-24 Nycomed Imaging As Contrast agents
GB9200391D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
ES2068151B1 (es) 1993-06-23 1995-11-16 Cabrera Garrido Juan Microespuma inyectable para esclerosis.
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
AU694135B2 (en) 1993-07-30 1998-07-16 Imcor Pharmaceutical Company Stabilized microbubble compositions for ultrasound
PT682530E (pt) * 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
DE19813174A1 (de) * 1998-03-25 1999-05-27 Schering Ag Mikropartikel aus Polymeren und mindestens einer gerüstbildenden Komponente und ihre Herstellung und Verwendung in der Ultraschalldiagnostik und zur ultraschallinduzierten Wirkstofffreisetzung
WO2000021578A1 (fr) 1998-10-12 2000-04-20 Mallinckrodt Inc. Agents de contraste pour ultrasons
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
WO2002080774A2 (fr) 2001-04-06 2002-10-17 Bracco Research S.A. Procede de mesure amelioree de parametres physiques locaux dans une cavite remplie de liquide
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2003074005A2 (fr) 2002-03-01 2003-09-12 Dyax Corp. Peptides liant des recepteurs kdr et vegf/kdr et leurs utilisations en diagnostic et therapie
WO2004065621A1 (fr) 2002-03-01 2004-08-05 Dyax Corp. Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
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DK2949658T3 (en) 2003-03-03 2018-10-01 Dyax Corp Peptides that specifically bind HGF receptor (cMet) and uses thereof
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US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
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US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
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US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
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US4277367A (en) * 1978-10-23 1981-07-07 Wisconsin Alumni Research Foundation Phantom material and method
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
CA1170569A (fr) * 1980-11-17 1984-07-10 Julia S. Rasor Prescurseurs de microbulles et methode de production et d'utilisation
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585955B1 (en) 1990-04-02 2003-07-01 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7033574B1 (en) 1990-04-02 2006-04-25 Bracco International B.V. Stable microbubbles suspensions injectable into living organisms
US6592846B1 (en) 1991-05-03 2003-07-15 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure resistant gas-filled microvesicles and methods for thereof preparation thereof
US6187288B1 (en) 1992-02-11 2001-02-13 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasonic echography
US5908610A (en) * 1992-11-02 1999-06-01 Bracco International B.V. Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography

Also Published As

Publication number Publication date
CA1232837A (fr) 1988-02-16
AU569072B2 (en) 1988-01-21
DE3313947A1 (de) 1984-10-18
DE3473829D1 (en) 1988-10-13
NO841490L (no) 1984-10-16
DK165622C (da) 1993-06-01
FI81265C (fi) 1990-10-10
JPS59205329A (ja) 1984-11-20
FI841463A0 (fi) 1984-04-12
JPH0417164B2 (fr) 1992-03-25
FI81265B (fi) 1990-06-29
IE840836L (en) 1984-10-15
AU2680684A (en) 1984-10-18
ATE36959T1 (de) 1988-09-15
EP0123235B1 (fr) 1988-09-07
NO163669B (no) 1990-03-26
NO163669C (no) 1990-07-04
IE57197B1 (en) 1992-06-03
DK165622B (da) 1992-12-28
FI841463A (fi) 1984-10-16
DK79084A (da) 1984-10-16
DK79084D0 (da) 1984-02-20
EP0123235A2 (fr) 1984-10-31
EP0123235A3 (en) 1986-11-20
NZ207854A (en) 1988-01-08

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