ZA831390B - Cephalosporin compounds - Google Patents

Cephalosporin compounds

Info

Publication number
ZA831390B
ZA831390B ZA831390A ZA831390A ZA831390B ZA 831390 B ZA831390 B ZA 831390B ZA 831390 A ZA831390 A ZA 831390A ZA 831390 A ZA831390 A ZA 831390A ZA 831390 B ZA831390 B ZA 831390B
Authority
ZA
South Africa
Prior art keywords
cephalosporin compounds
cephalosporin
compounds
Prior art date
Application number
ZA831390A
Other languages
English (en)
Inventor
Aburaki Shimpei
Kamachi Hajime
Narita Yukio
Okumura Jun
Naito Takayuki
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA831390B publication Critical patent/ZA831390B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA831390A 1982-03-04 1983-03-01 Cephalosporin compounds ZA831390B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/354,851 US4406899A (en) 1982-03-04 1982-03-04 Cephalosporins

Publications (1)

Publication Number Publication Date
ZA831390B true ZA831390B (en) 1984-02-29

Family

ID=23395168

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA831390A ZA831390B (en) 1982-03-04 1983-03-01 Cephalosporin compounds

Country Status (4)

Country Link
US (1) US4406899A (xx)
JP (1) JPS58174387A (xx)
SU (1) SU1303029A3 (xx)
ZA (1) ZA831390B (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
DE3169452D1 (en) * 1980-12-09 1985-04-25 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
GB8410000D0 (en) * 1984-04-17 1984-05-31 Fujisawa Pharmaceutical Co Cephem compounds
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
JPH06104674B2 (ja) * 1984-11-12 1994-12-21 萬有製薬株式会社 新規セフアロスポリン誘導体
JPH06102668B2 (ja) * 1985-08-06 1994-12-14 萬有製薬株式会社 新規セフアロスポリン誘導体
EP0182210B1 (en) * 1984-11-12 1991-02-27 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
DE3585434D1 (de) * 1984-12-27 1992-04-02 Banyu Pharma Co Ltd Cephalosporinverbindungen.
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
AT393452B (de) * 1985-08-05 1991-10-25 Bristol Myers Squibb Co Verfahren zur herstellung eines cephalosporinpraeparates zur herstellung einer injektionsloesung
CA1284994C (en) * 1985-08-05 1991-06-18 Murray Arthur Kaplan Cephalosporin salts and injectable compositions
US4994451A (en) * 1988-01-19 1991-02-19 Bristol-Myers Company Cephalosporin salts and injectable compositions
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4659812A (en) * 1985-08-20 1987-04-21 Bristol-Myers Company Cephalosporin intermediates
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
US4680389A (en) * 1986-01-10 1987-07-14 Bristol-Myers Company Temperature stable crystalline di(1-methyl-2-pyrralidinone) and di(N-formylpyrrolidine) adducts of cephalosporin derivatives
EP0237735B1 (en) * 1986-03-17 1994-03-30 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-3-cephem compounds and process for production of the same
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
US5594129A (en) * 1991-09-10 1997-01-14 Bristol-Myers Squibb Company Process for the preparation of a cephalosporin antibiotic
US5698703A (en) * 1991-09-10 1997-12-16 Bristol-Myers Squibb Company Syn-isomer of thiazolyl intermediate and process for the preparation thereof
CA2099692C (en) * 1992-07-24 2003-09-30 Gary M. F. Lim Process for preparing cephalosporin intermediates
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
US5391729A (en) * 1992-09-08 1995-02-21 Bristol-Myers Squibb Company Crystalline dihydrate of a cephalosporin salt
US5401842A (en) * 1992-09-08 1995-03-28 Bristol-Myers Squibb Company Injectable compositions of a cephalosporin dihydrate salt
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
JP2723088B2 (ja) * 1994-09-07 1998-03-09 藤沢薬品工業株式会社 セファロスポリン化合物の新規な結晶
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ES2348299T3 (es) 2003-04-16 2010-12-02 Sandoz Ag Procedimientos para la preparación de cefepime.
ES2298850T3 (es) * 2003-12-23 2008-05-16 Sandoz Gmbh Proceso para la produccion de intermedios para utilizar en la sintesis de la cefalosporina.
CN100396688C (zh) * 2004-05-20 2008-06-25 江苏恒瑞医药股份有限公司 头孢烯类化合物磷酸酯及其制备方法和用途
EP1773845A1 (en) 2004-07-16 2007-04-18 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
WO2007129176A2 (en) * 2006-04-28 2007-11-15 Wockhardt Ltd Improvements in therapy for treating resistant bacterial infections
CN101210023B (zh) * 2006-12-30 2010-12-08 山东轩竹医药科技有限公司 一种头孢菌素衍生物
CN103958527A (zh) 2011-10-04 2014-07-30 盐野义制药株式会社 具有儿茶酚基团的头孢烯衍生物
EP3386977A4 (en) * 2015-12-10 2019-05-22 NAEJA-RGM Pharmaceuticals ULC CEPHEM COMPOUNDS, THEIR PREPARATION AND USE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2760484C2 (xx) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
JPS53103493A (en) 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
IT1207006B (it) * 1978-11-15 1989-05-17 Glaxo Group Ltd Antibiotici cefalosporinici composizioni che li contengono e procedimento per produrli

Also Published As

Publication number Publication date
JPS58174387A (ja) 1983-10-13
US4406899A (en) 1983-09-27
SU1303029A3 (ru) 1987-04-07
JPH0326197B2 (xx) 1991-04-10

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