ZA794923B - New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents - Google Patents

New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents

Info

Publication number
ZA794923B
ZA794923B ZA00794923A ZA794923A ZA794923B ZA 794923 B ZA794923 B ZA 794923B ZA 00794923 A ZA00794923 A ZA 00794923A ZA 794923 A ZA794923 A ZA 794923A ZA 794923 B ZA794923 B ZA 794923B
Authority
ZA
South Africa
Prior art keywords
formula
lower alkyl
new
hydrogen
pyrrolyl
Prior art date
Application number
ZA00794923A
Other languages
English (en)
Inventor
E Bellasio
N Mola
A Campi
E Baldoli
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of ZA794923B publication Critical patent/ZA794923B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
ZA00794923A 1978-10-02 1979-09-17 New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents ZA794923B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7838898 1978-10-02

Publications (1)

Publication Number Publication Date
ZA794923B true ZA794923B (en) 1980-09-24

Family

ID=10500040

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00794923A ZA794923B (en) 1978-10-02 1979-09-17 New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents

Country Status (15)

Country Link
EP (1) EP0009655B1 (hu)
JP (1) JPS5569577A (hu)
AT (1) ATE3294T1 (hu)
AU (1) AU529482B2 (hu)
CA (1) CA1144165A (hu)
DE (1) DE2965377D1 (hu)
DK (1) DK151803C (hu)
ES (1) ES484616A1 (hu)
FI (1) FI65998C (hu)
GR (1) GR69856B (hu)
IE (1) IE49017B1 (hu)
IL (1) IL58256A (hu)
NO (1) NO151620C (hu)
YU (1) YU41886B (hu)
ZA (1) ZA794923B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1150070B (it) * 1980-12-22 1986-12-10 Lepetit Spa Procedimento per preparare derivati n-pirrolipiridazinamminici
US5254622A (en) * 1988-12-09 1993-10-19 Asahi Kasei Kogyo Kabushiki Kaisha ABS resin compositions and molded articles thereof having improved coating performances
ATE555789T1 (de) 2003-07-30 2012-05-15 Xenon Pharmaceuticals Inc Pyridazinderivate und deren verwendung als therapeutische mittel
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515483A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
TW200626139A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
EP1799667B1 (en) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
USD916552S1 (en) * 2019-07-26 2021-04-20 Spectrum Diversified Designs, Llc Trivet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1168334A (en) * 1967-01-25 1969-10-22 Lepetit Spa New Pharmacologically Active Pyridazines
GB1378102A (en) * 1972-03-14 1974-12-18 Lepetit Spa Antihypertensive compositions
GB1408362A (en) * 1973-05-25 1975-10-01 Lepetit Spa 2-pyrrol-1-yl amino 4,5-dihydro-1-h-imidazole derivatives
AU477837B2 (en) * 1973-05-30 1974-12-05 I. S. F. Sp. A New anti-hypertensive compounds having a high therapeutic index and a long-term hypotensive effect
ES431009A1 (es) * 1974-05-09 1976-10-16 Isf Spa Procedimiento para la preparacion de derivados de 3-benci- lidenhidracino-6-aminopiridacina.

Also Published As

Publication number Publication date
FI65998C (fi) 1984-08-10
DE2965377D1 (en) 1983-06-16
DK151803B (da) 1988-01-04
YU41886B (en) 1988-02-29
FI65998B (fi) 1984-04-30
EP0009655B1 (en) 1983-05-11
NO151620C (no) 1985-05-08
IE791866L (en) 1980-04-02
ES484616A1 (es) 1980-05-16
FI792832A (fi) 1980-04-03
GR69856B (hu) 1982-07-19
AU5086679A (en) 1980-04-17
DK400679A (da) 1980-04-03
IE49017B1 (en) 1985-07-10
NO793151L (no) 1980-04-08
NO151620B (no) 1985-01-28
DK151803C (da) 1988-06-13
ATE3294T1 (de) 1983-05-15
YU237479A (en) 1983-02-28
AU529482B2 (en) 1983-06-09
JPH0321553B2 (hu) 1991-03-22
IL58256A0 (en) 1979-12-30
CA1144165A (en) 1983-04-05
JPS5569577A (en) 1980-05-26
IL58256A (en) 1984-02-29
EP0009655A1 (en) 1980-04-16

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