ZA767431B - Novel pyrazinecarboxamides and processes for preparing same - Google Patents

Novel pyrazinecarboxamides and processes for preparing same

Info

Publication number
ZA767431B
ZA767431B ZA00767431A ZA767431A ZA767431B ZA 767431 B ZA767431 B ZA 767431B ZA 00767431 A ZA00767431 A ZA 00767431A ZA 767431 A ZA767431 A ZA 767431A ZA 767431 B ZA767431 B ZA 767431B
Authority
ZA
South Africa
Prior art keywords
pyrazinecarboxamides
novel
processes
preparing same
preparing
Prior art date
Application number
ZA00767431A
Other languages
English (en)
Inventor
C Habecker
E Cragoe
O Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA767431B publication Critical patent/ZA767431B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
ZA00767431A 1975-12-15 1976-12-14 Novel pyrazinecarboxamides and processes for preparing same ZA767431B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64080375A 1975-12-15 1975-12-15

Publications (1)

Publication Number Publication Date
ZA767431B true ZA767431B (en) 1978-07-26

Family

ID=24569755

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00767431A ZA767431B (en) 1975-12-15 1976-12-14 Novel pyrazinecarboxamides and processes for preparing same

Country Status (14)

Country Link
US (1) US4085211A (de)
JP (1) JPS52106877A (de)
AU (1) AU511429B2 (de)
BE (1) BE849379A (de)
CH (1) CH630369A5 (de)
DE (1) DE2656374A1 (de)
DK (1) DK531476A (de)
ES (2) ES454160A1 (de)
FR (1) FR2335226A1 (de)
GB (1) GB1527297A (de)
HU (1) HU175504B (de)
NL (1) NL7613276A (de)
SE (1) SE431452B (de)
ZA (1) ZA767431B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208413A (en) * 1977-03-04 1980-06-17 Merck & Co., Inc. N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
US4163781A (en) * 1978-04-17 1979-08-07 Merck & Co., Inc. 3-Amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamide compounds, compositions and methods of use
EP0009054A1 (de) * 1978-09-19 1980-04-02 Merck & Co. Inc. N'-substituierte N-Pyrazincarbonyl-sulfamoylguanidine und Verfahren zu ihrer Herstellung
US4277602A (en) * 1980-07-02 1981-07-07 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-truazin-2-yl)2-pyrazinecarboxamides
US4272537A (en) * 1980-07-02 1981-06-09 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides
IE52345B1 (en) * 1981-02-02 1987-09-16 Ici Plc Alkanolamine derivatives
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
JPS62291361A (ja) * 1986-06-09 1987-12-18 株式会社ブリヂストン 床支持装置
JPS6342741U (de) * 1986-09-04 1988-03-22
GB8810934D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Amides
GB8810933D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8812342D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
GB8812343D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Amino compounds
JPH02101937U (de) * 1989-01-31 1990-08-14
AUPP646498A0 (en) * 1998-10-12 1998-11-05 Australian National University, The A method of modulating ion channel functional activity
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US8143256B2 (en) 2004-08-18 2012-03-27 Parion Sciences, Inc. Cyclic amide and ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP5455922B2 (ja) * 2007-12-10 2014-03-26 ノバルティス アーゲー 有機化合物
DE102008053024B4 (de) 2008-10-24 2015-04-30 RUHR-UNIVERSITäT BOCHUM Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
PE20151054A1 (es) 2012-12-17 2015-08-07 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
JP6607191B2 (ja) * 2014-09-18 2019-11-20 日産化学株式会社 液晶配向剤、液晶配向膜、及び液晶表示素子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (de) * 1962-10-30
BE639393A (de) * 1962-10-30

Also Published As

Publication number Publication date
SE431452B (sv) 1984-02-06
FR2335226B1 (de) 1979-03-09
JPS52106877A (en) 1977-09-07
GB1527297A (en) 1978-10-04
JPS6238350B2 (de) 1987-08-17
CH630369A5 (de) 1982-06-15
DE2656374C2 (de) 1989-08-10
NL7613276A (nl) 1977-06-17
BE849379A (fr) 1977-06-14
SE7613289L (sv) 1977-06-16
FR2335226A1 (fr) 1977-07-15
AU511429B2 (en) 1980-08-21
AU2018176A (en) 1978-06-08
US4085211A (en) 1978-04-18
DK531476A (da) 1977-06-16
ES454160A1 (es) 1978-03-01
HU175504B (hu) 1980-08-28
DE2656374A1 (de) 1977-06-16
ES465742A1 (es) 1978-10-01

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