ZA755861B - Novel salts of biguanides - Google Patents
Novel salts of biguanidesInfo
- Publication number
- ZA755861B ZA755861B ZA00755861A ZA755861A ZA755861B ZA 755861 B ZA755861 B ZA 755861B ZA 00755861 A ZA00755861 A ZA 00755861A ZA 755861 A ZA755861 A ZA 755861A ZA 755861 B ZA755861 B ZA 755861B
- Authority
- ZA
- South Africa
- Prior art keywords
- biguanides
- novel salts
- salts
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1369774A CH602612A5 (es) | 1974-10-11 | 1974-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA755861B true ZA755861B (en) | 1976-08-25 |
Family
ID=4394567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00755861A ZA755861B (en) | 1974-10-11 | 1975-09-15 | Novel salts of biguanides |
Country Status (26)
Country | Link |
---|---|
US (1) | US4028402A (es) |
JP (1) | JPS51125718A (es) |
AR (1) | AR209457A1 (es) |
AT (1) | AT343676B (es) |
BE (1) | BE834369A (es) |
BR (1) | BR7506595A (es) |
CA (1) | CA1053258A (es) |
CH (1) | CH602612A5 (es) |
CU (1) | CU34371A (es) |
DD (1) | DD123322A5 (es) |
DE (1) | DE2542598A1 (es) |
DK (1) | DK140834B (es) |
ES (1) | ES441673A1 (es) |
FI (1) | FI752626A (es) |
FR (1) | FR2287221A1 (es) |
GB (1) | GB1473256A (es) |
IE (1) | IE41807B1 (es) |
IL (1) | IL48116A (es) |
LU (1) | LU73557A1 (es) |
NL (1) | NL7511890A (es) |
NO (1) | NO753447L (es) |
PH (1) | PH12279A (es) |
PL (1) | PL95259B1 (es) |
SE (1) | SE7511357L (es) |
SU (1) | SU572200A3 (es) |
ZA (1) | ZA755861B (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2401898A1 (fr) * | 1977-09-05 | 1979-03-30 | Aec Chim Organ Biolog | Nouveau sel de l'acide patoique |
US20020006899A1 (en) * | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
WO1998027982A1 (fr) | 1996-12-24 | 1998-07-02 | Sumitomo Pharmaceuticals Co., Ltd. | Composition contenant de l'acide ascorbique |
DE19823831A1 (de) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
US20030176357A1 (en) * | 1998-10-06 | 2003-09-18 | Pospisilik Andrew J. | Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels |
DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
DE19940130A1 (de) * | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
US7169407B1 (en) | 1999-10-06 | 2007-01-30 | Toshio Miyata | Carbonyl stress-decreasing agent |
US20080076811A1 (en) * | 2000-01-21 | 2008-03-27 | Bork Balkan | Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents |
DE60137216D1 (de) * | 2000-03-31 | 2009-02-12 | Prosidion Ltd | Verbesserung der aktivität der inselzellen bei diabetes mellitus und dessen prävention |
FR2809310B1 (fr) | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
JP2005097117A (ja) * | 2000-06-30 | 2005-04-14 | Chugai Pharmaceut Co Ltd | 糖尿病治療剤 |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
CA2424475A1 (en) * | 2000-10-27 | 2002-05-02 | Probiodrug Ag | Method for the treatment of neurological and neuropsychological disorders |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
JP2005504766A (ja) * | 2001-08-16 | 2005-02-17 | プロバイオドラッグ アーゲー | プロリンエンドペプチダーゼ阻害剤の、細胞内シグナルカスケード依存性イノシトール(1,4,5)トリホスフェート濃度調節への使用。 |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
DE20220238U1 (de) | 2002-02-28 | 2003-05-08 | Probiodrug AG, 06120 Halle | Glutaminyl basierte DPIV Inhibitoren |
US20030232761A1 (en) * | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
US20040033051A1 (en) * | 2002-08-16 | 2004-02-19 | Ip Kiril Kun Wan | Method and system for producing and displaying visual presentations which inhibit off-screen duplication |
EP1543023B1 (en) * | 2002-09-18 | 2010-03-17 | Prosidion Limited | Secondary binding site of dipeptidyl peptidase iv (dp iv) |
US20040058876A1 (en) * | 2002-09-18 | 2004-03-25 | Torsten Hoffmann | Secondary binding site of dipeptidyl peptidase IV (DP IV) |
JP4806628B2 (ja) | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
KR20100106630A (ko) | 2003-05-05 | 2010-10-01 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
BRPI0415409A (pt) * | 2003-10-15 | 2006-12-05 | Probiodrug Ag | uso de efetuadores de ciclases de glutaminila e glutamato |
US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
US20100099721A1 (en) * | 2003-11-03 | 2010-04-22 | Probiodrug Ag | Novel compounds for the treatment of neurological disorders |
BRPI0507485A (pt) | 2004-02-05 | 2007-07-10 | Probiodrug Ag | inibidores novos de glutaminil ciclase |
US8058312B2 (en) * | 2007-01-29 | 2011-11-15 | Hanall Biopharma Co., Ltd. | N, N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same |
WO2008097861A2 (en) * | 2007-02-02 | 2008-08-14 | Braincells, Inc. | MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS |
KR101226669B1 (ko) * | 2007-09-21 | 2013-01-25 | 한올바이오파마주식회사 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
WO2009088220A2 (ko) * | 2008-01-08 | 2009-07-16 | Hanall Pharmaceutical Company. Ltd | N,n-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물 |
PL2303838T3 (pl) * | 2008-06-26 | 2014-07-31 | Laboratorios Silanes S A De C V | Nowa sól glicynianowa metforminy do kontroli glukozy we krwi |
WO2010146604A2 (en) | 2009-06-18 | 2010-12-23 | Exemed Pharmaceuticals | Processes for preparing metformin hydrochloride |
WO2011049400A2 (ko) * | 2009-10-23 | 2011-04-28 | 한올바이오파마주식회사 | N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물 |
KR101324283B1 (ko) | 2010-04-27 | 2013-11-01 | 한올바이오파마주식회사 | 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물 |
WO2018060962A2 (en) | 2016-09-30 | 2018-04-05 | Laboratorios Silanes S.A. De C.V. | Metformin amino acid compounds and methods of using the same |
MX2019003725A (es) | 2016-09-30 | 2019-08-12 | Laboratorios Silanes S A De C V | Glicinato de metformina, composiciones farmaceuticas que comprenden la misma, y metodos de uso de la misma. |
CN107118130A (zh) * | 2017-05-11 | 2017-09-01 | 杜剑平 | 一类治疗肿瘤的药物化合物及其应用 |
CN106986791A (zh) * | 2017-05-11 | 2017-07-28 | 杜剑平 | 一种治疗肿瘤的药物化合物及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3179562A (en) * | 1961-08-23 | 1965-04-20 | Du Pont | Treatment of diabetes with alpha, alpha substituted acetic acid derivatives |
-
1974
- 1974-10-11 CH CH1369774A patent/CH602612A5/xx not_active IP Right Cessation
-
1975
- 1975-09-15 ZA ZA00755861A patent/ZA755861B/xx unknown
- 1975-09-17 IL IL48116A patent/IL48116A/xx unknown
- 1975-09-19 FI FI752626A patent/FI752626A/fi not_active Application Discontinuation
- 1975-09-24 DE DE19752542598 patent/DE2542598A1/de not_active Withdrawn
- 1975-10-06 IE IE2184/75A patent/IE41807B1/en unknown
- 1975-10-08 US US05/620,525 patent/US4028402A/en not_active Expired - Lifetime
- 1975-10-08 PH PH17640A patent/PH12279A/en unknown
- 1975-10-08 CU CU7534371A patent/CU34371A/es unknown
- 1975-10-09 BR BR7506595*A patent/BR7506595A/pt unknown
- 1975-10-09 CA CA237,343A patent/CA1053258A/en not_active Expired
- 1975-10-09 SU SU7502178502A patent/SU572200A3/ru active
- 1975-10-09 NL NL7511890A patent/NL7511890A/xx not_active Application Discontinuation
- 1975-10-09 FR FR7530907A patent/FR2287221A1/fr not_active Withdrawn
- 1975-10-09 LU LU73557A patent/LU73557A1/xx unknown
- 1975-10-09 JP JP50121432A patent/JPS51125718A/ja active Pending
- 1975-10-09 SE SE7511357A patent/SE7511357L/xx unknown
- 1975-10-10 ES ES441673A patent/ES441673A1/es not_active Expired
- 1975-10-10 NO NO753447A patent/NO753447L/no unknown
- 1975-10-10 DD DD188797A patent/DD123322A5/xx unknown
- 1975-10-10 BE BE160823A patent/BE834369A/xx unknown
- 1975-10-10 DK DK457475AA patent/DK140834B/da unknown
- 1975-10-10 GB GB4161175A patent/GB1473256A/en not_active Expired
- 1975-10-10 PL PL1975183923A patent/PL95259B1/pl unknown
- 1975-10-10 AT AT776375A patent/AT343676B/de active
- 1975-10-11 AR AR260639A patent/AR209457A1/es active
Also Published As
Publication number | Publication date |
---|---|
DK457475A (es) | 1976-04-12 |
JPS51125718A (en) | 1976-11-02 |
IE41807L (en) | 1976-04-11 |
SU572200A3 (ru) | 1977-09-05 |
CA1053258A (en) | 1979-04-24 |
PH12279A (en) | 1978-12-12 |
DD123322A5 (es) | 1976-12-12 |
SE7511357L (sv) | 1976-04-12 |
DK140834C (es) | 1980-04-28 |
DE2542598A1 (de) | 1976-04-22 |
AR209457A1 (es) | 1977-04-29 |
IL48116A (en) | 1979-07-25 |
CU34371A (es) | 1979-06-01 |
FI752626A (es) | 1976-04-12 |
BR7506595A (pt) | 1976-08-17 |
ATA776375A (de) | 1977-10-15 |
DK140834B (da) | 1979-11-26 |
BE834369A (fr) | 1976-04-12 |
PL95259B1 (pl) | 1977-10-31 |
CH602612A5 (es) | 1978-07-31 |
AU8497775A (en) | 1977-03-24 |
NO753447L (es) | 1976-04-13 |
GB1473256A (en) | 1977-05-11 |
US4028402A (en) | 1977-06-07 |
FR2287221A1 (fr) | 1976-05-07 |
IL48116A0 (en) | 1975-11-25 |
ES441673A1 (es) | 1977-04-01 |
IE41807B1 (en) | 1980-03-26 |
NL7511890A (nl) | 1976-04-13 |
LU73557A1 (es) | 1977-05-24 |
AT343676B (de) | 1978-06-12 |
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