ZA71928B - "1-(substituted benzyl)tetrahydro-2-(ih)pyrimidones" - Google Patents

"1-(substituted benzyl)tetrahydro-2-(ih)pyrimidones"

Info

Publication number
ZA71928B
ZA71928B ZA710928A ZA71928A ZA71928B ZA 71928 B ZA71928 B ZA 71928B ZA 710928 A ZA710928 A ZA 710928A ZA 71928 A ZA71928 A ZA 71928A ZA 71928 B ZA71928 B ZA 71928B
Authority
ZA
South Africa
Prior art keywords
pyrimidones
tetrahydro
substituted benzyl
benzyl
substituted
Prior art date
Application number
ZA710928A
Other languages
English (en)
Inventor
J Butterfield
T Schwan
S Burrous
Original Assignee
Norwich Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Pharma Co filed Critical Norwich Pharma Co
Publication of ZA71928B publication Critical patent/ZA71928B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
ZA710928A 1970-03-05 1971-02-15 "1-(substituted benzyl)tetrahydro-2-(ih)pyrimidones" ZA71928B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1698270A 1970-03-05 1970-03-05

Publications (1)

Publication Number Publication Date
ZA71928B true ZA71928B (en) 1972-09-27

Family

ID=21780073

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA710928A ZA71928B (en) 1970-03-05 1971-02-15 "1-(substituted benzyl)tetrahydro-2-(ih)pyrimidones"

Country Status (14)

Country Link
US (1) US3681349A (index.php)
AT (1) AT305288B (index.php)
BE (1) BE763745A (index.php)
CH (1) CH555343A (index.php)
DE (1) DE2110445C3 (index.php)
DK (1) DK127427B (index.php)
ES (1) ES388780A1 (index.php)
FR (1) FR2085673B1 (index.php)
GB (1) GB1294626A (index.php)
IL (1) IL36189A0 (index.php)
NL (1) NL7102519A (index.php)
NO (1) NO130728C (index.php)
SE (1) SE376420B (index.php)
ZA (1) ZA71928B (index.php)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39003A (en) * 1971-03-25 1975-02-10 Morton Norwich Products Inc 1-(substituted benzyl)tetrahydro-2-(1h)-pyrimidones and their preparation
US3957785A (en) * 1971-12-02 1976-05-18 Societa' Farmaceutici Italia S.P.A. Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
US3956325A (en) * 1974-01-21 1976-05-11 Smithkline Corporation 5-Heterocyclic-1,2,3,6-tetrahydro-4(5H) pyrimidinone
US4003900A (en) * 1976-03-11 1977-01-18 Morton-Norwich Products, Inc. 1-Benzyl-5-chloro-2-(1H)-pyrimidone
US4002627A (en) * 1976-03-26 1977-01-11 Morton-Norwich Products, Inc. 1-Benzyl-3-methyl-3,4,5,6-tetrahydro-2(1H) pyrimidone
US4052399A (en) * 1976-09-13 1977-10-04 Morton-Norwich Products, Inc. 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride
US4052400A (en) * 1976-10-29 1977-10-04 Morton-Norwich Products, Inc. Hypertensive 1-substituted 2(1h)-pyrimidones
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8575156B2 (en) * 2007-07-26 2013-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
EP2252598A2 (en) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201004945A (en) * 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
NZ588954A (en) * 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN104327062A (zh) * 2008-07-25 2015-02-04 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
GEP20156309B (en) * 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2496589B1 (en) 2009-11-05 2014-03-05 Boehringer Ingelheim International GmbH Novel chiral phosphorus ligands
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
WO2011149822A1 (en) 2010-05-26 2011-12-01 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
EA201300522A1 (ru) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтические комбинации для лечения метаболических нарушений
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE562987A (index.php) * 1956-12-05
DE1121617B (de) * 1959-05-26 1962-01-11 Huels Chemische Werke Ag Verfahren zur Herstellung von Tetrahydropyrimidin-2-onderivaten
DE1545601A1 (de) * 1965-07-22 1969-08-07 Basf Ag Verfahren zur Herstellung von Hexahydro-pyrimidinderivaten
DE1670368A1 (de) * 1966-07-16 1970-11-05 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung aralkylsubstituierter Lactame und Cyclischer Harnstoffe
DE1670241A1 (de) * 1967-07-01 1971-01-28 Basf Ag Verfahren zur Herstellung von 2-Oxohexahydropyrimidinen

Also Published As

Publication number Publication date
DE2110445C3 (de) 1975-05-28
SE376420B (index.php) 1975-05-26
IL36189A0 (en) 1971-04-28
FR2085673A1 (index.php) 1971-12-31
BE763745A (fr) 1971-09-03
US3681349A (en) 1972-08-01
DE2110445B2 (de) 1974-10-10
CH555343A (de) 1974-10-31
DE2110445A1 (de) 1971-11-04
GB1294626A (en) 1972-11-01
NL7102519A (index.php) 1971-09-07
NO130728C (index.php) 1975-01-29
FR2085673B1 (index.php) 1974-09-06
NO130728B (index.php) 1974-10-21
ES388780A1 (es) 1975-03-01
AT305288B (de) 1973-02-26
DK127427B (da) 1973-11-05

Similar Documents

Publication Publication Date Title
ZA71928B (en) "1-(substituted benzyl)tetrahydro-2-(ih)pyrimidones"
CH556860A (de) Procede de preparation d'azapurinones.
ZA71120B (en) 3,4 dihydro-1,2,3-oxathiazin-4-ones
BE763741A (fr) Distributeur d'aerosol
CH519672A (de) Valvola per l'erogazione di quantità dosate di sostanze aerosol da contenitori di tali sostanze
ZA711691B (en) Amine solutions of 1,2-benzisothiazolone
IL35743A0 (en) New 1,2,4-thiadiazole compounds
BE768383A (fr) Cyclopropane-carboxylates d'alcynyl-benzyle
IL36515A (en) Isoxazolopyrimidin-4-one herbicides
JPS5598103A (en) Novel quinazolinone herbicide
ZA712312B (en) 4,14-estradiene compounds
AU5852873A (en) Cardenolide-3-%2@-desoxy-glycosides<
ZA711532B (en) 3,5-dialkyl hydantoins
ZA711784B (en) New herbicidal ureas
PH11322A (en) 2-halo-4-substituted-6,7,8 trialcoxy quinazolines
ZA721832B (en) 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)-pyrimidones
IL37063A0 (en) 1,2,4-triazole derivatives
ZA70476B (en) "verbeterde hengelmetode"
CA952968A (en) Procede d'enregistrement
CA847875A (en) Procede d'hydrodimerisation electrolytique
CA855190A (en) Procede d'hydrodimerisation electrolytique
CA996114A (en) 1-(substituted benzye)-2-(ih) pyrimidones
AU3151271A (en) Substituted 1, 3-indandiols
ZA713471B (en) 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piperidino)butyramides
CA924473A (en) Element d'habillage de construction