CH556860A - Procede de preparation d'azapurinones. - Google Patents

Procede de preparation d'azapurinones.

Info

Publication number
CH556860A
CH556860A CH1853772A CH1853772A CH556860A CH 556860 A CH556860 A CH 556860A CH 1853772 A CH1853772 A CH 1853772A CH 1853772 A CH1853772 A CH 1853772A CH 556860 A CH556860 A CH 556860A
Authority
CH
Switzerland
Prior art keywords
azapurinones
procede
preparation
Prior art date
Application number
CH1853772A
Other languages
English (en)
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of CH556860A publication Critical patent/CH556860A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1853772A 1970-12-15 1971-12-14 Procede de preparation d'azapurinones. CH556860A (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5955270 1970-12-15
GB5955670 1970-12-15
GB4975671A GB1338235A (en) 1970-12-15 1971-10-26 Azapurinones
GB5345771 1971-11-17

Publications (1)

Publication Number Publication Date
CH556860A true CH556860A (de) 1974-12-13

Family

ID=27449009

Family Applications (5)

Application Number Title Priority Date Filing Date
CH1853772A CH556860A (de) 1970-12-15 1971-12-14 Procede de preparation d'azapurinones.
CH1853872A CH546779A (fr) 1970-12-15 1971-12-14 Procede de preparation de sels pharmaceutiquement acceptables.
CH222574A CH552610A (fr) 1970-12-15 1971-12-14 Procede de preparation d'azapurinones.
CH1853672A CH550814A (fr) 1970-12-15 1971-12-14 Procede de preparation de nouvelles aza-8 purinones-6 substituees en 2.
CH1823271A CH555351A (fr) 1970-12-15 1971-12-14 Procede de preparation de nouvelles aza-8 purenones-6 substituees en 2.

Family Applications After (4)

Application Number Title Priority Date Filing Date
CH1853872A CH546779A (fr) 1970-12-15 1971-12-14 Procede de preparation de sels pharmaceutiquement acceptables.
CH222574A CH552610A (fr) 1970-12-15 1971-12-14 Procede de preparation d'azapurinones.
CH1853672A CH550814A (fr) 1970-12-15 1971-12-14 Procede de preparation de nouvelles aza-8 purinones-6 substituees en 2.
CH1823271A CH555351A (fr) 1970-12-15 1971-12-14 Procede de preparation de nouvelles aza-8 purenones-6 substituees en 2.

Country Status (25)

Country Link
US (1) US3987160A (de)
JP (1) JPS5310599B1 (de)
AR (4) AR192602A1 (de)
AT (4) AT315839B (de)
AU (1) AU458277B2 (de)
BE (1) BE776683A (de)
BG (3) BG20806A3 (de)
CH (5) CH556860A (de)
DD (1) DD95007A5 (de)
DE (1) DE2162096A1 (de)
DK (1) DK141249B (de)
FI (1) FI53457C (de)
FR (1) FR2118078B1 (de)
GB (1) GB1338235A (de)
HK (1) HK42177A (de)
HU (1) HU165079B (de)
IE (1) IE35897B1 (de)
IL (1) IL38364A (de)
IS (1) IS1099B6 (de)
LU (1) LU64457A1 (de)
NL (1) NL174943C (de)
NO (1) NO134257C (de)
OA (1) OA03930A (de)
SE (1) SE393381B (de)
ZM (1) ZM18971A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
FR2406638A1 (fr) * 1977-10-21 1979-05-18 May & Baker Ltd Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant
EP0007727B1 (de) * 1978-07-24 1983-11-30 Beecham Group Plc Benzopyranotriazole, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende pharmazeutische Zusammensetzung
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
CA1303037C (en) * 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Purinone derivatives as bronchodilators vasodilators and anti-allergic agents
DE3873812D1 (de) * 1987-04-07 1992-09-24 Ciba Geigy Ag 3h-1,2,3-triazolo(4,5-d)pyrimidine.
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
DE4211239C2 (de) * 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
US5734053A (en) * 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
IL135462A0 (en) 1997-11-12 2001-05-20 Bayer Ag 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE19838705A1 (de) 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
AU2017378409A1 (en) 2016-12-14 2019-07-04 Respira Therapeutics, Inc. Methods and compositions for treatment of pulmonary hypertension and other lung disorders
TW202043234A (zh) 2019-01-24 2020-12-01 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
TW202219047A (zh) * 2020-07-23 2022-05-16 美商普羅米修斯生物科學股份有限公司 靶向gpr35之治療劑

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407204A (en) * 1944-07-22 1946-09-03 American Cyanamid Co Triazolo (d) pyrimidines and methods of preparing the same
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars

Also Published As

Publication number Publication date
AT317211B (de) 1974-08-26
ZM18971A1 (en) 1972-08-21
NL174943C (nl) 1984-09-03
DE2162096A1 (de) 1972-07-06
US3987160A (en) 1976-10-19
IS2047A7 (is) 1972-06-16
OA03930A (fr) 1975-08-14
AT315838B (de) 1974-06-10
AT315839B (de) 1974-06-10
CH555351A (fr) 1974-10-31
CH552610A (fr) 1974-08-15
IS1099B6 (is) 1982-11-18
FR2118078B1 (de) 1975-08-01
FI53457C (fi) 1978-05-10
DD95007A5 (de) 1973-01-12
AU3686771A (en) 1973-06-21
CH550814A (fr) 1974-06-28
BE776683A (fr) 1972-06-14
FI53457B (de) 1978-01-31
BG20807A3 (de) 1975-12-20
HU165079B (de) 1974-06-28
AR199467A1 (es) 1974-09-09
HK42177A (en) 1977-08-19
AR199468A1 (es) 1974-09-09
AU458277B2 (en) 1975-02-20
JPS5310599B1 (de) 1978-04-14
BG20805A3 (de) 1975-12-20
CH546779A (fr) 1974-03-15
LU64457A1 (de) 1972-08-23
DK141249C (de) 1980-08-04
NL7117142A (de) 1972-06-19
FR2118078A1 (de) 1972-07-28
IE35897L (en) 1972-06-15
IE35897B1 (en) 1976-06-23
BG20806A3 (de) 1975-12-20
GB1338235A (en) 1973-11-21
DK141249B (da) 1980-02-11
DE2162096C2 (de) 1988-02-11
IL38364A0 (en) 1972-02-29
NO134257B (de) 1976-05-31
AR192602A1 (es) 1973-02-28
AT319235B (de) 1974-12-10
NO134257C (de) 1976-09-08
NL174943B (nl) 1984-04-02
AR192689A1 (es) 1973-02-28
IL38364A (en) 1975-08-31
SE393381B (sv) 1977-05-09

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Legal Events

Date Code Title Description
PL Patent ceased