AT315838B - Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten - Google Patents
Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivatenInfo
- Publication number
- AT315838B AT315838B AT1075671A AT1075671A AT315838B AT 315838 B AT315838 B AT 315838B AT 1075671 A AT1075671 A AT 1075671A AT 1075671 A AT1075671 A AT 1075671A AT 315838 B AT315838 B AT 315838B
- Authority
- AT
- Austria
- Prior art keywords
- azapurin
- derivatives
- new
- production
- Prior art date
Links
- WTVSOESDARPVQO-UHFFFAOYSA-N triazolo[4,5-d]pyrimidin-7-one Chemical class O=C1N=CN=C2N=NN=C12 WTVSOESDARPVQO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5955270 | 1970-12-15 | ||
| GB5955670 | 1970-12-15 | ||
| GB4975671A GB1338235A (en) | 1970-12-15 | 1971-10-26 | Azapurinones |
| GB5345771 | 1971-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT315838B true AT315838B (de) | 1974-06-10 |
Family
ID=27449009
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT272473A AT315839B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von pharmazeutisch zulässigen Salzen von neuen 8-Azapurin-6-on-derivaten |
| AT1075671A AT315838B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten |
| AT272373A AT317211B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen |
| AT272273A AT319235B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT272473A AT315839B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von pharmazeutisch zulässigen Salzen von neuen 8-Azapurin-6-on-derivaten |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT272373A AT317211B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen |
| AT272273A AT319235B (de) | 1970-12-15 | 1971-12-15 | Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3987160A (de) |
| JP (1) | JPS5310599B1 (de) |
| AR (4) | AR192602A1 (de) |
| AT (4) | AT315839B (de) |
| AU (1) | AU458277B2 (de) |
| BE (1) | BE776683A (de) |
| BG (3) | BG20805A3 (de) |
| CH (5) | CH556860A (de) |
| DD (1) | DD95007A5 (de) |
| DE (1) | DE2162096A1 (de) |
| DK (1) | DK141249B (de) |
| FI (1) | FI53457C (de) |
| FR (1) | FR2118078B1 (de) |
| GB (1) | GB1338235A (de) |
| HK (1) | HK42177A (de) |
| HU (1) | HU165079B (de) |
| IE (1) | IE35897B1 (de) |
| IL (1) | IL38364A (de) |
| IS (1) | IS1099B6 (de) |
| LU (1) | LU64457A1 (de) |
| NL (1) | NL174943C (de) |
| NO (1) | NO134257C (de) |
| OA (1) | OA03930A (de) |
| SE (1) | SE393381B (de) |
| ZM (1) | ZM18971A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1493685A (en) * | 1970-12-15 | 1977-11-30 | May & Baker Ltd | 8-azapurinones |
| BE792648A (fr) * | 1971-12-13 | 1973-06-12 | May & Baker Ltd | Derives de l'isoquinoleine |
| FR2406638A1 (fr) * | 1977-10-21 | 1979-05-18 | May & Baker Ltd | Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant |
| DE2966444D1 (en) * | 1978-07-24 | 1984-01-05 | Beecham Group Plc | Benzopyranotriazoles, preparation of these compounds and pharmaceutical composition containing them |
| JPS60226887A (ja) * | 1984-04-25 | 1985-11-12 | Dai Ichi Seiyaku Co Ltd | トリアゾロピリミジン誘導体 |
| CA1303037C (en) * | 1987-02-02 | 1992-06-09 | Smith Kline & French Laboratories Limited | Purinone derivatives as bronchodilators vasodilators and anti-allergic agents |
| EP0288431B1 (de) * | 1987-04-07 | 1992-08-19 | Ciba-Geigy Ag | 3H-1,2,3-Triazolo[4,5-d]pyrimidine |
| US5204353A (en) * | 1987-04-07 | 1993-04-20 | Ciba-Geigy Corporation | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith |
| FR2618073B1 (fr) * | 1987-07-16 | 1990-09-07 | Pf Medicament | Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation |
| GB8817651D0 (en) * | 1988-07-25 | 1988-09-01 | Smith Kline French Lab | Chemical compounds |
| DE4211239C2 (de) * | 1992-04-03 | 1995-11-16 | Max Planck Gesellschaft | Arzneimittel gegen Herz-Kreislauf-Erkrankungen |
| GB9213623D0 (en) * | 1992-06-26 | 1992-08-12 | Pfizer Ltd | Therapeutic agents |
| US5734053A (en) * | 1992-06-26 | 1998-03-31 | Pfizer Inc | Purinone antianginal agents |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6129930A (en) * | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6080428A (en) * | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US20080045573A1 (en) * | 1993-09-20 | 2008-02-21 | Bova David J | Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia |
| GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| PT1049695E (pt) | 1997-11-12 | 2002-07-31 | Bayer Ag | Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase |
| DE19838705A1 (de) * | 1998-08-26 | 2000-03-02 | Bayer Ag | Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one |
| IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
| DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2328910B1 (de) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃアゴニストの調製方法 |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| CN110381951A (zh) | 2016-12-14 | 2019-10-25 | 瑞必治公司 | 用于治疗肺性高血压和其他肺病症的方法及组合物 |
| TWI845600B (zh) | 2019-01-24 | 2024-06-21 | 美商普羅米修斯生物科學股份有限公司 | Gpr35調節劑 |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
| CA3186635A1 (en) * | 2020-07-23 | 2022-01-27 | Robert Higuchi | Therapeutic agents targeting gpr35 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2407204A (en) * | 1944-07-22 | 1946-09-03 | American Cyanamid Co | Triazolo (d) pyrimidines and methods of preparing the same |
| US2993039A (en) * | 1959-11-06 | 1961-07-18 | Upjohn Co | Preparing nu-glycosides of aldose and ketose sugars |
-
1971
- 1971-10-26 GB GB4975671A patent/GB1338235A/en not_active Expired
- 1971-12-06 DK DK596371AA patent/DK141249B/da not_active IP Right Cessation
- 1971-12-14 LU LU64457D patent/LU64457A1/xx unknown
- 1971-12-14 AU AU36867/71A patent/AU458277B2/en not_active Expired
- 1971-12-14 IL IL38364A patent/IL38364A/xx unknown
- 1971-12-14 FI FI3560/71A patent/FI53457C/fi active
- 1971-12-14 IE IE1583/71A patent/IE35897B1/xx unknown
- 1971-12-14 CH CH1853772A patent/CH556860A/de not_active IP Right Cessation
- 1971-12-14 SE SE7116090A patent/SE393381B/xx unknown
- 1971-12-14 JP JP10078571A patent/JPS5310599B1/ja active Pending
- 1971-12-14 HU HUMA2296A patent/HU165079B/hu unknown
- 1971-12-14 NL NLAANVRAGE7117142,A patent/NL174943C/xx not_active IP Right Cessation
- 1971-12-14 NO NO4614/71A patent/NO134257C/no unknown
- 1971-12-14 CH CH1853672A patent/CH550814A/fr not_active IP Right Cessation
- 1971-12-14 DE DE19712162096 patent/DE2162096A1/de active Granted
- 1971-12-14 BE BE776683A patent/BE776683A/xx not_active IP Right Cessation
- 1971-12-14 ZM ZM189/71A patent/ZM18971A1/xx unknown
- 1971-12-14 DD DD159572A patent/DD95007A5/xx unknown
- 1971-12-14 CH CH1823271A patent/CH555351A/fr not_active IP Right Cessation
- 1971-12-14 CH CH222574A patent/CH552610A/fr not_active IP Right Cessation
- 1971-12-14 CH CH1853872A patent/CH546779A/fr not_active IP Right Cessation
- 1971-12-14 FR FR7144869A patent/FR2118078B1/fr not_active Expired
- 1971-12-14 OA OA54440A patent/OA03930A/xx unknown
- 1971-12-14 IS IS2047A patent/IS1099B6/is unknown
- 1971-12-15 BG BG019250A patent/BG20805A3/xx unknown
- 1971-12-15 BG BG020379A patent/BG20806A3/xx unknown
- 1971-12-15 AT AT272473A patent/AT315839B/de not_active IP Right Cessation
- 1971-12-15 AT AT1075671A patent/AT315838B/de not_active IP Right Cessation
- 1971-12-15 AT AT272373A patent/AT317211B/de not_active IP Right Cessation
- 1971-12-15 AT AT272273A patent/AT319235B/de not_active IP Right Cessation
- 1971-12-15 BG BG020380A patent/BG20807A3/xx unknown
- 1971-12-15 AR AR239632A patent/AR192602A1/es active
-
1972
- 1972-12-06 AR AR245508A patent/AR199467A1/es active
- 1972-12-06 AR AR245509A patent/AR199468A1/es active
- 1972-12-06 AR AR245510A patent/AR192689A1/es active
-
1973
- 1973-05-29 US US05/364,425 patent/US3987160A/en not_active Expired - Lifetime
-
1977
- 1977-08-11 HK HK421/77A patent/HK42177A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |