ZA202001834B - Dextromethorphan transdermal delivery device - Google Patents
Dextromethorphan transdermal delivery deviceInfo
- Publication number
- ZA202001834B ZA202001834B ZA2020/01834A ZA202001834A ZA202001834B ZA 202001834 B ZA202001834 B ZA 202001834B ZA 2020/01834 A ZA2020/01834 A ZA 2020/01834A ZA 202001834 A ZA202001834 A ZA 202001834A ZA 202001834 B ZA202001834 B ZA 202001834B
- Authority
- ZA
- South Africa
- Prior art keywords
- transdermal delivery
- delivery device
- dextromethorphan
- methods
- adhesive layer
- Prior art date
Links
- 230000037317 transdermal delivery Effects 0.000 title abstract 5
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 title abstract 4
- 229960001985 dextromethorphan Drugs 0.000 title abstract 4
- 239000012790 adhesive layer Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568028P | 2017-10-04 | 2017-10-04 | |
| US201862680182P | 2018-06-04 | 2018-06-04 | |
| PCT/US2018/054178 WO2019070864A1 (en) | 2017-10-04 | 2018-10-03 | DEVICE FOR TRANSDERMAL DEXTROMETHORPHAN DELIVERY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA202001834B true ZA202001834B (en) | 2024-10-30 |
Family
ID=65994772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2020/01834A ZA202001834B (en) | 2017-10-04 | 2020-03-23 | Dextromethorphan transdermal delivery device |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11382869B2 (https=) |
| EP (1) | EP3691641A4 (https=) |
| JP (2) | JP2020536953A (https=) |
| KR (1) | KR20200062254A (https=) |
| CN (1) | CN111343980B (https=) |
| AU (1) | AU2018345723B2 (https=) |
| BR (1) | BR112020006723A2 (https=) |
| CA (1) | CA3078369A1 (https=) |
| IL (1) | IL273735B2 (https=) |
| MX (1) | MX2020003044A (https=) |
| TW (1) | TWI795446B (https=) |
| WO (1) | WO2019070864A1 (https=) |
| ZA (1) | ZA202001834B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
| EP4125902A4 (en) * | 2020-03-30 | 2024-05-22 | Shinkei Therapeutics, Inc. | TRANSDERMAL ADMINISTRATION OF DEXTROMETHORPHAN |
| EP4183391A4 (en) * | 2020-07-20 | 2024-04-17 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMPOSITION AND ITS USE |
| AU2022207514A1 (en) * | 2021-01-18 | 2023-07-27 | Antecip Bioventures Ii Llc | Combination of an antidepressant and dextromethorphan for neuropsychiatric conditions |
| CN113720944B (zh) * | 2021-09-30 | 2023-04-28 | 珠海润都制药股份有限公司 | 一种氢溴酸右美沙芬硫酸奎尼丁胶囊含量的检测方法 |
| TW202430177A (zh) * | 2022-10-06 | 2024-08-01 | 美商神經治療股份有限公司 | 右旋美索芬之經皮輸送 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3020630B2 (ja) * | 1991-03-27 | 2000-03-15 | 三井化学株式会社 | 薬物投与用粘着剤 |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| JP3021661B2 (ja) * | 1994-03-07 | 2000-03-15 | セラテック・インコーポレーテッド | 薬剤含有接着複合体の経皮放出デバイス |
| SE9601528D0 (sv) * | 1996-04-23 | 1996-04-23 | Pharmacia Ab | Transdermally administered dextromethorphan as antitissue agent |
| TWI326214B (en) | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| SI1530469T1 (sl) * | 2002-08-20 | 2009-06-30 | Euro Celtique Sa | Transdermalna odmerna oblika, ki obsega aktivno sredstvo in antagonist v obliki soli in v obliki proste baze |
| KR20060126701A (ko) * | 2003-12-10 | 2006-12-08 | 애크럭스 디디에스 피티와이 리미티드 | 경피 또는 국소 약물 전달에 따른 원치않는 효과의치료방법 |
| US20060223786A1 (en) | 2005-04-01 | 2006-10-05 | Smith David J | Transdermal pain control method and device |
| ATE481096T1 (de) * | 2005-04-06 | 2010-10-15 | Adamas Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen |
| EP1986639A4 (en) * | 2006-02-03 | 2010-04-28 | Avanir Pharmaceuticals | PHARMACEUTICAL COMPOSITIONS OF DEXTROMETHORPHANE AND CHINIDINE FOR THE TREATMENT OF DEPRESSION, FEAR STATES AND NEURODEEGENERATIVE DISEASES |
| US20070248657A1 (en) * | 2006-04-25 | 2007-10-25 | Smith David J | Multi-compartment transdermal pain control device |
| CA2676133A1 (en) * | 2006-10-09 | 2008-04-17 | Smithkline Beecham Corporation | Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage |
| WO2009021058A2 (en) | 2007-08-06 | 2009-02-12 | Trinity Labortories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2010062690A1 (en) | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
| RU2544702C2 (ru) * | 2009-04-24 | 2015-03-20 | Хенкель Корпорейшн | Клеи на основе силикон-акрилового гибридного полимера |
| US20140051718A1 (en) * | 2012-04-16 | 2014-02-20 | Antecip Bioventures Ii Llc | Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan |
| MY179696A (en) | 2013-11-05 | 2020-11-11 | Antecip Bioventures Ii Llc | Compositions and methods comprising bupropion or related compounds and dextromethorphan |
| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
-
2018
- 2018-10-02 TW TW107134828A patent/TWI795446B/zh active
- 2018-10-03 US US16/753,471 patent/US11382869B2/en active Active
- 2018-10-03 JP JP2020540680A patent/JP2020536953A/ja active Pending
- 2018-10-03 EP EP18864063.5A patent/EP3691641A4/en active Pending
- 2018-10-03 CA CA3078369A patent/CA3078369A1/en active Pending
- 2018-10-03 KR KR1020207011696A patent/KR20200062254A/ko not_active Ceased
- 2018-10-03 WO PCT/US2018/054178 patent/WO2019070864A1/en not_active Ceased
- 2018-10-03 AU AU2018345723A patent/AU2018345723B2/en active Active
- 2018-10-03 BR BR112020006723-7A patent/BR112020006723A2/pt unknown
- 2018-10-03 IL IL273735A patent/IL273735B2/en unknown
- 2018-10-03 MX MX2020003044A patent/MX2020003044A/es unknown
- 2018-10-03 CN CN201880072989.3A patent/CN111343980B/zh active Active
-
2020
- 2020-03-23 ZA ZA2020/01834A patent/ZA202001834B/en unknown
-
2022
- 2022-07-06 US US17/858,471 patent/US20220331264A1/en not_active Abandoned
-
2023
- 2023-08-25 JP JP2023136898A patent/JP7609943B2/ja active Active
- 2023-10-19 US US18/381,849 patent/US20240189252A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3078369A1 (en) | 2019-04-11 |
| US20240189252A1 (en) | 2024-06-13 |
| EP3691641A4 (en) | 2021-04-07 |
| MX2020003044A (es) | 2020-08-13 |
| IL273735B1 (en) | 2024-04-01 |
| IL273735B2 (en) | 2024-08-01 |
| CN111343980A (zh) | 2020-06-26 |
| AU2018345723A8 (en) | 2020-04-23 |
| JP7609943B2 (ja) | 2025-01-07 |
| BR112020006723A2 (pt) | 2020-10-06 |
| WO2019070864A1 (en) | 2019-04-11 |
| EP3691641A1 (en) | 2020-08-12 |
| US20220331264A1 (en) | 2022-10-20 |
| AU2018345723A1 (en) | 2020-04-16 |
| RU2020115169A3 (https=) | 2022-02-16 |
| US11382869B2 (en) | 2022-07-12 |
| US20200323788A1 (en) | 2020-10-15 |
| IL273735A (en) | 2020-05-31 |
| TW201922232A (zh) | 2019-06-16 |
| RU2020115169A (ru) | 2021-11-08 |
| JP2020536953A (ja) | 2020-12-17 |
| CN111343980B (zh) | 2024-02-27 |
| AU2018345723B2 (en) | 2024-09-19 |
| JP2023159366A (ja) | 2023-10-31 |
| KR20200062254A (ko) | 2020-06-03 |
| TWI795446B (zh) | 2023-03-11 |
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