CN111343980B - 右美沙芬经皮递送装置 - Google Patents

右美沙芬经皮递送装置 Download PDF

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Publication number
CN111343980B
CN111343980B CN201880072989.3A CN201880072989A CN111343980B CN 111343980 B CN111343980 B CN 111343980B CN 201880072989 A CN201880072989 A CN 201880072989A CN 111343980 B CN111343980 B CN 111343980B
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China
Prior art keywords
dextromethorphan
transdermal delivery
delivery device
day
subject
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CN201880072989.3A
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English (en)
Chinese (zh)
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CN111343980A (zh
Inventor
S·博萨迪亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New Kai Therapeutics Ltd
Xinkai Treatment Co ltd
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New Kai Therapeutics Ltd
Xinkai Treatment Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880072989.3A 2017-10-04 2018-10-03 右美沙芬经皮递送装置 Active CN111343980B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568028P 2017-10-04 2017-10-04
US62/568,028 2017-10-04
US201862680182P 2018-06-04 2018-06-04
US62/680,182 2018-06-04
PCT/US2018/054178 WO2019070864A1 (en) 2017-10-04 2018-10-03 DEVICE FOR TRANSDERMAL DEXTROMETHORPHAN DELIVERY

Publications (2)

Publication Number Publication Date
CN111343980A CN111343980A (zh) 2020-06-26
CN111343980B true CN111343980B (zh) 2024-02-27

Family

ID=65994772

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880072989.3A Active CN111343980B (zh) 2017-10-04 2018-10-03 右美沙芬经皮递送装置

Country Status (13)

Country Link
US (3) US11382869B2 (https=)
EP (1) EP3691641A4 (https=)
JP (2) JP2020536953A (https=)
KR (1) KR20200062254A (https=)
CN (1) CN111343980B (https=)
AU (1) AU2018345723B2 (https=)
BR (1) BR112020006723A2 (https=)
CA (1) CA3078369A1 (https=)
IL (1) IL273735B2 (https=)
MX (1) MX2020003044A (https=)
TW (1) TWI795446B (https=)
WO (1) WO2019070864A1 (https=)
ZA (1) ZA202001834B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置
EP4125902A4 (en) * 2020-03-30 2024-05-22 Shinkei Therapeutics, Inc. TRANSDERMAL ADMINISTRATION OF DEXTROMETHORPHAN
EP4183391A4 (en) * 2020-07-20 2024-04-17 Shenzhen Salubris Pharmaceuticals Co., Ltd. PHARMACEUTICAL COMPOSITION AND ITS USE
AU2022207514A1 (en) * 2021-01-18 2023-07-27 Antecip Bioventures Ii Llc Combination of an antidepressant and dextromethorphan for neuropsychiatric conditions
CN113720944B (zh) * 2021-09-30 2023-04-28 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊含量的检测方法
TW202430177A (zh) * 2022-10-06 2024-08-01 美商神經治療股份有限公司 右旋美索芬之經皮輸送

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297415A (ja) * 1991-03-27 1992-10-21 Mitsui Petrochem Ind Ltd 薬物投与用粘着剤
US6335030B1 (en) * 1996-04-23 2002-01-01 Pharmacia & Upjohn Ab Transdermally administered dextromethorphan as antitussive agent
WO2015069809A1 (en) * 2013-11-05 2015-05-14 Antecip Bioventures Ii Llc Compositions and methods comprising bupropion or related compounds and dextromethorphan

Family Cites Families (15)

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US5206248A (en) 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
JP3021661B2 (ja) * 1994-03-07 2000-03-15 セラテック・インコーポレーテッド 薬剤含有接着複合体の経皮放出デバイス
TWI326214B (en) 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
SI1530469T1 (sl) * 2002-08-20 2009-06-30 Euro Celtique Sa Transdermalna odmerna oblika, ki obsega aktivno sredstvo in antagonist v obliki soli in v obliki proste baze
KR20060126701A (ko) * 2003-12-10 2006-12-08 애크럭스 디디에스 피티와이 리미티드 경피 또는 국소 약물 전달에 따른 원치않는 효과의치료방법
US20060223786A1 (en) 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
ATE481096T1 (de) * 2005-04-06 2010-10-15 Adamas Pharmaceuticals Inc Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen
EP1986639A4 (en) * 2006-02-03 2010-04-28 Avanir Pharmaceuticals PHARMACEUTICAL COMPOSITIONS OF DEXTROMETHORPHANE AND CHINIDINE FOR THE TREATMENT OF DEPRESSION, FEAR STATES AND NEURODEEGENERATIVE DISEASES
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
CA2676133A1 (en) * 2006-10-09 2008-04-17 Smithkline Beecham Corporation Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage
WO2009021058A2 (en) 2007-08-06 2009-02-12 Trinity Labortories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
WO2010062690A1 (en) 2008-10-30 2010-06-03 Concert Pharmaceuticals Inc. Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury
RU2544702C2 (ru) * 2009-04-24 2015-03-20 Хенкель Корпорейшн Клеи на основе силикон-акрилового гибридного полимера
US20140051718A1 (en) * 2012-04-16 2014-02-20 Antecip Bioventures Ii Llc Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297415A (ja) * 1991-03-27 1992-10-21 Mitsui Petrochem Ind Ltd 薬物投与用粘着剤
US6335030B1 (en) * 1996-04-23 2002-01-01 Pharmacia & Upjohn Ab Transdermally administered dextromethorphan as antitussive agent
WO2015069809A1 (en) * 2013-11-05 2015-05-14 Antecip Bioventures Ii Llc Compositions and methods comprising bupropion or related compounds and dextromethorphan

Non-Patent Citations (2)

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Title
Dextromethorphan/Quinidine for the Treatment of Pseudobulbar Affect;Edna Patatanian等;《The CONSULTANT PHARMACIST》;第29卷(第04期);第264-269页 *
Simultaneous determination of dextromethorphan and its metabolites in human plasma by capillary electrophoresis;Helle T. Kristensen;《Journal of Pharmaceutical and Biomedical Analysis》;19981201;第18卷;第827-838页 *

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CA3078369A1 (en) 2019-04-11
US20240189252A1 (en) 2024-06-13
EP3691641A4 (en) 2021-04-07
MX2020003044A (es) 2020-08-13
ZA202001834B (en) 2024-10-30
IL273735B1 (en) 2024-04-01
IL273735B2 (en) 2024-08-01
CN111343980A (zh) 2020-06-26
AU2018345723A8 (en) 2020-04-23
JP7609943B2 (ja) 2025-01-07
BR112020006723A2 (pt) 2020-10-06
WO2019070864A1 (en) 2019-04-11
EP3691641A1 (en) 2020-08-12
US20220331264A1 (en) 2022-10-20
AU2018345723A1 (en) 2020-04-16
RU2020115169A3 (https=) 2022-02-16
US11382869B2 (en) 2022-07-12
US20200323788A1 (en) 2020-10-15
IL273735A (en) 2020-05-31
TW201922232A (zh) 2019-06-16
RU2020115169A (ru) 2021-11-08
JP2020536953A (ja) 2020-12-17
AU2018345723B2 (en) 2024-09-19
JP2023159366A (ja) 2023-10-31
KR20200062254A (ko) 2020-06-03
TWI795446B (zh) 2023-03-11

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