ZA201800787B - Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy - Google Patents
Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapyInfo
- Publication number
- ZA201800787B ZA201800787B ZA2018/00787A ZA201800787A ZA201800787B ZA 201800787 B ZA201800787 B ZA 201800787B ZA 2018/00787 A ZA2018/00787 A ZA 2018/00787A ZA 201800787 A ZA201800787 A ZA 201800787A ZA 201800787 B ZA201800787 B ZA 201800787B
- Authority
- ZA
- South Africa
- Prior art keywords
- ido1
- tdo
- oxide
- dioxygenases
- tryptophan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ71151415 | 2015-08-27 | ||
| PCT/NZ2016/050135 WO2017034420A1 (en) | 2015-08-27 | 2016-08-25 | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201800787B true ZA201800787B (en) | 2025-08-27 |
Family
ID=58100623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2018/00787A ZA201800787B (en) | 2015-08-27 | 2018-02-06 | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11414428B2 (enExample) |
| EP (1) | EP3350188B1 (enExample) |
| JP (2) | JP7334041B2 (enExample) |
| KR (1) | KR20180048798A (enExample) |
| CN (1) | CN108349997B (enExample) |
| AU (2) | AU2016312848A1 (enExample) |
| CA (1) | CA2996681C (enExample) |
| WO (1) | WO2017034420A1 (enExample) |
| ZA (1) | ZA201800787B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108349997B (zh) * | 2015-08-27 | 2025-06-10 | 奥克兰联合服务有限公司 | 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途 |
| CN108969522B (zh) | 2017-06-05 | 2023-03-28 | 复旦大学 | N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途 |
| GB201809050D0 (en) | 2018-06-01 | 2018-07-18 | E Therapeutics Plc | Modulators of tryptophan catabolism |
| JP7566731B2 (ja) | 2018-07-03 | 2024-10-15 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US12152018B2 (en) | 2021-01-08 | 2024-11-26 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with STING activity |
| US20240091202A1 (en) | 2021-03-05 | 2024-03-21 | Universität Basel | Compositions for the treatment of ebv associated diseases or conditions |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| WO2023166492A2 (en) | 2022-03-04 | 2023-09-07 | Antido Therapeutics International Sàrl | Dual inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001079193A2 (en) | 2000-04-14 | 2001-10-25 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| WO2005089753A2 (en) * | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders |
| TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| DE102005018389A1 (de) | 2005-04-20 | 2006-10-26 | Sanofi-Aventis Deutschland Gmbh | Azolderivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| CA2754934A1 (en) | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
| JP2013519685A (ja) | 2010-02-11 | 2013-05-30 | ヴァンダービルト ユニバーシティー | ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法 |
| JP6039554B2 (ja) | 2010-07-22 | 2016-12-07 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 除草性イソオキサゾロ［５，４−ｂ］ピリジン |
| EP2802212B1 (en) | 2012-01-12 | 2015-12-30 | Basf Se | Herbicidal isoxazolo[5,4-b]pyridines |
| PL220630B1 (pl) | 2012-12-28 | 2015-11-30 | Inst Immunologii I Terapii Doświadczalnej Pan | Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny |
| EA201591610A1 (ru) * | 2013-03-14 | 2015-12-30 | Курадев Фарма Прайвит Лтд. | Ингибиторы кинуренинового пути |
| WO2015082499A2 (en) | 2013-12-03 | 2015-06-11 | Iomet Pharma Ltd | Pharmaceutical compound |
| JP7323985B2 (ja) | 2014-08-13 | 2023-08-09 | オークランド ユニサービシーズ リミティド | トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用 |
| CN108349997B (zh) * | 2015-08-27 | 2025-06-10 | 奥克兰联合服务有限公司 | 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途 |
| RU2619120C1 (ru) | 2016-06-06 | 2017-05-12 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике |
-
2016
- 2016-08-25 CN CN201680063267.2A patent/CN108349997B/zh active Active
- 2016-08-25 US US15/755,750 patent/US11414428B2/en active Active
- 2016-08-25 AU AU2016312848A patent/AU2016312848A1/en not_active Abandoned
- 2016-08-25 EP EP16839685.1A patent/EP3350188B1/en active Active
- 2016-08-25 JP JP2018511057A patent/JP7334041B2/ja active Active
- 2016-08-25 CA CA2996681A patent/CA2996681C/en active Active
- 2016-08-25 WO PCT/NZ2016/050135 patent/WO2017034420A1/en not_active Ceased
- 2016-08-25 KR KR1020187008532A patent/KR20180048798A/ko not_active Withdrawn
-
2018
- 2018-02-06 ZA ZA2018/00787A patent/ZA201800787B/en unknown
-
2021
- 2021-08-03 AU AU2021212003A patent/AU2021212003B2/en active Active
- 2021-11-08 JP JP2021182007A patent/JP2022033753A/ja active Pending
-
2022
- 2022-08-15 US US17/888,281 patent/US20220411438A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018525430A (ja) | 2018-09-06 |
| AU2021212003B2 (en) | 2023-09-14 |
| EP3350188B1 (en) | 2024-03-13 |
| US20180244692A1 (en) | 2018-08-30 |
| US20220411438A1 (en) | 2022-12-29 |
| CN108349997B (zh) | 2025-06-10 |
| JP7334041B2 (ja) | 2023-08-28 |
| CN108349997A (zh) | 2018-07-31 |
| AU2021212003A1 (en) | 2021-08-26 |
| JP2022033753A (ja) | 2022-03-02 |
| HK1258665A1 (en) | 2019-11-15 |
| US11414428B2 (en) | 2022-08-16 |
| CA2996681C (en) | 2024-04-09 |
| EP3350188A4 (en) | 2019-04-03 |
| WO2017034420A1 (en) | 2017-03-02 |
| AU2016312848A1 (en) | 2018-03-29 |
| EP3350188A1 (en) | 2018-07-25 |
| KR20180048798A (ko) | 2018-05-10 |
| CA2996681A1 (en) | 2017-03-02 |
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