JP7334041B2 - トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 - Google Patents

トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 Download PDF

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JP7334041B2
JP7334041B2 JP2018511057A JP2018511057A JP7334041B2 JP 7334041 B2 JP7334041 B2 JP 7334041B2 JP 2018511057 A JP2018511057 A JP 2018511057A JP 2018511057 A JP2018511057 A JP 2018511057A JP 7334041 B2 JP7334041 B2 JP 7334041B2
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JP2018525430A (ja
JP2018525430A5 (enExample
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デスモンド パルマー ブライアン
チン ライ－ミン
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オークランド ユニサービシーズ リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2018511057A 2015-08-27 2016-08-25 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 Active JP7334041B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021182007A JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ71151415 2015-08-27
NZ711514 2015-08-27
PCT/NZ2016/050135 WO2017034420A1 (en) 2015-08-27 2016-08-25 Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Related Child Applications (1)

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JP2021182007A Division JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

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JP2018525430A JP2018525430A (ja) 2018-09-06
JP2018525430A5 JP2018525430A5 (enExample) 2019-10-10
JP7334041B2 true JP7334041B2 (ja) 2023-08-28

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JP2018511057A Active JP7334041B2 (ja) 2015-08-27 2016-08-25 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用
JP2021182007A Pending JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

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JP2021182007A Pending JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

Country Status (9)

Country Link
US (2) US11414428B2 (enExample)
EP (1) EP3350188B1 (enExample)
JP (2) JP7334041B2 (enExample)
KR (1) KR20180048798A (enExample)
CN (1) CN108349997B (enExample)
AU (2) AU2016312848A1 (enExample)
CA (1) CA2996681C (enExample)
WO (1) WO2017034420A1 (enExample)
ZA (1) ZA201800787B (enExample)

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Publication number Priority date Publication date Assignee Title
CN108349997B (zh) * 2015-08-27 2025-06-10 奥克兰联合服务有限公司 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途
CN108969522B (zh) 2017-06-05 2023-03-28 复旦大学 N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
JP7566731B2 (ja) 2018-07-03 2024-10-15 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物
US12152018B2 (en) 2021-01-08 2024-11-26 Ifm Due, Inc. Compounds and compositions for treating conditions associated with STING activity
US20240091202A1 (en) 2021-03-05 2024-03-21 Universität Basel Compositions for the treatment of ebv associated diseases or conditions
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
WO2023166492A2 (en) 2022-03-04 2023-09-07 Antido Therapeutics International Sàrl Dual inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Citations (1)

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JP2008536884A (ja) 2005-04-20 2008-09-11 サノフィ−アベンティス リパーゼ及びホスホリパーゼの阻害剤の形態のアゾール誘導体

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DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
US8461159B2 (en) 2008-11-25 2013-06-11 Jannsen Pharmaceutica BV Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
WO2010068452A1 (en) * 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
CA2754934A1 (en) 2009-03-10 2010-09-16 Gruenenthal Gmbh Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators
JP2013519685A (ja) 2010-02-11 2013-05-30 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法
JP6039554B2 (ja) 2010-07-22 2016-12-07 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 除草性イソオキサゾロ［５，４−ｂ］ピリジン
EP2802212B1 (en) 2012-01-12 2015-12-30 Basf Se Herbicidal isoxazolo[5,4-b]pyridines
PL220630B1 (pl) 2012-12-28 2015-11-30 Inst Immunologii I Terapii Doświadczalnej Pan Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny
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CN108349997B (zh) * 2015-08-27 2025-06-10 奥克兰联合服务有限公司 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途
RU2619120C1 (ru) 2016-06-06 2017-05-12 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике

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Ａｃｔａ Ｐｏｌｏｎｉａｅ Ｐｈａｒｍａｃｅｕｔｉｃａ－Ｄｒｕｇ Ｒｅｓｅａｒｃｈ，２００３， Ｖｏｌ．６０， Ｎｏ．４，ｐｐ．２９３－３０１
Ａｃｔａ Ｐｏｌｏｎｉａｅ Ｐｈａｒｍａｃｅｕｔｉｃａ－Ｄｒｕｇ Ｒｅｓｅａｒｃｈ，２０１５．０８．０３， Ｖｏｌ．７２， Ｎｏ．４，ｐｐ．７２７－７３５

Also Published As

Publication number Publication date
JP2018525430A (ja) 2018-09-06
AU2021212003B2 (en) 2023-09-14
EP3350188B1 (en) 2024-03-13
US20180244692A1 (en) 2018-08-30
US20220411438A1 (en) 2022-12-29
CN108349997B (zh) 2025-06-10
CN108349997A (zh) 2018-07-31
AU2021212003A1 (en) 2021-08-26
JP2022033753A (ja) 2022-03-02
HK1258665A1 (en) 2019-11-15
US11414428B2 (en) 2022-08-16
CA2996681C (en) 2024-04-09
EP3350188A4 (en) 2019-04-03
WO2017034420A1 (en) 2017-03-02
AU2016312848A1 (en) 2018-03-29
EP3350188A1 (en) 2018-07-25
KR20180048798A (ko) 2018-05-10
ZA201800787B (en) 2025-08-27
CA2996681A1 (en) 2017-03-02

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