ZA201607850B - Apelin receptor (apj) agonists and uses thereof - Google Patents

Apelin receptor (apj) agonists and uses thereof

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Publication number
ZA201607850B
ZA201607850B ZA2016/07850A ZA201607850A ZA201607850B ZA 201607850 B ZA201607850 B ZA 201607850B ZA 2016/07850 A ZA2016/07850 A ZA 2016/07850A ZA 201607850 A ZA201607850 A ZA 201607850A ZA 201607850 B ZA201607850 B ZA 201607850B
Authority
ZA
South Africa
Prior art keywords
apj
agonists
apelin receptor
apelin
receptor
Prior art date
Application number
ZA2016/07850A
Other languages
English (en)
Inventor
P Runyon Scott
Maitra Rangan
Narayanan Sanju
Barnwell Thomas James
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Publication of ZA201607850B publication Critical patent/ZA201607850B/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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ZA2016/07850A 2014-06-06 2016-11-14 Apelin receptor (apj) agonists and uses thereof ZA201607850B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462008688P 2014-06-06 2014-06-06
PCT/US2015/034427 WO2015188073A1 (en) 2014-06-06 2015-06-05 Apelin receptor (apj) agonists and uses thereof

Publications (1)

Publication Number Publication Date
ZA201607850B true ZA201607850B (en) 2018-05-30

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ZA2016/07850A ZA201607850B (en) 2014-06-06 2016-11-14 Apelin receptor (apj) agonists and uses thereof

Country Status (15)

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US (2) US10377718B2 (ja)
EP (1) EP3152200A1 (ja)
JP (1) JP6767878B2 (ja)
KR (1) KR102509043B1 (ja)
CN (1) CN106459004B (ja)
AU (1) AU2015269247B2 (ja)
BR (1) BR112016028119A2 (ja)
CA (1) CA2949559C (ja)
IL (1) IL248988A0 (ja)
MA (1) MA39999A (ja)
MX (1) MX2016014890A (ja)
PE (1) PE20170664A1 (ja)
RU (1) RU2705800C2 (ja)
WO (1) WO2015188073A1 (ja)
ZA (1) ZA201607850B (ja)

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GB201415569D0 (en) 2014-09-03 2014-10-15 C4X Discovery Ltd Therapeutic Compounds
US10647689B2 (en) * 2015-04-28 2020-05-12 Sanford Burnham Prebys Medical Discovery Institute Apelin receptor agonists and methods of use thereof
AU2016263564B2 (en) 2015-05-20 2019-12-05 Amgen Inc. Triazole agonists of the APJ receptor
EA034857B1 (ru) * 2015-10-14 2020-03-30 Бристол-Маерс Сквибб Компани 2,4-дигидроксиникотинамиды как агонисты apj
MA43417A (fr) * 2015-12-09 2018-10-17 Res Triangle Inst Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations
EP3390400B1 (en) * 2015-12-16 2021-01-20 Bristol-Myers Squibb Company Heteroarylhydroxypyrimidinones as agonists of the apj receptor
GB201601703D0 (en) 2016-01-29 2016-03-16 C4X Discovery Ltd Therapeutic compounds
JP6716711B2 (ja) * 2016-03-24 2020-07-01 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ａｐｊアゴニストとしての６−ヒドロキシ−４−オキソ−１，４−ジヒドロピリミジン−５−カルボキシアミド
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
CN109790151B (zh) 2016-10-12 2022-03-29 三角研究所 杂环爱帕琳肽受体(apj)激动剂及其用途
JP7037558B2 (ja) * 2016-10-14 2022-03-16 ブリストル－マイヤーズ スクイブ カンパニー ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト
CN110072531A (zh) * 2016-10-19 2019-07-30 阿维夫公司 用于治疗心血管相关疾病的爱帕琳的新型聚乙二醇化的脂质体制剂
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
WO2018097945A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
EP3541792B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
WO2018093576A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
WO2018207881A1 (ja) * 2017-05-12 2018-11-15 武田薬品工業株式会社 複素環化合物
EP3704122B1 (en) 2017-11-03 2021-09-01 Amgen Inc. Fused triazole agonists of the apj receptor
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
WO2021041791A1 (en) 2019-08-29 2021-03-04 Rti International, Inc. Methods and uses for apelin receptor agonists
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