ZA201403106B - Methods for treating cancers using oral formulations of cytidine analogs - Google Patents
Methods for treating cancers using oral formulations of cytidine analogsInfo
- Publication number
- ZA201403106B ZA201403106B ZA2014/03106A ZA201403106A ZA201403106B ZA 201403106 B ZA201403106 B ZA 201403106B ZA 2014/03106 A ZA2014/03106 A ZA 2014/03106A ZA 201403106 A ZA201403106 A ZA 201403106A ZA 201403106 B ZA201403106 B ZA 201403106B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- oral formulations
- treating cancers
- cytidine analogs
- cytidine
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554344P | 2011-11-01 | 2011-11-01 | |
| PCT/US2012/062845 WO2013067043A1 (en) | 2011-11-01 | 2012-10-31 | Methods for treating cancers using oral formulations of cytidine analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201403106B true ZA201403106B (en) | 2015-08-26 |
Family
ID=47146759
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/03106A ZA201403106B (en) | 2011-11-01 | 2014-04-29 | Methods for treating cancers using oral formulations of cytidine analogs |
| ZA2015/02909A ZA201502909B (en) | 2011-11-01 | 2015-04-28 | Methods for treating cancers using oral formulations of cytidine analogs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2015/02909A ZA201502909B (en) | 2011-11-01 | 2015-04-28 | Methods for treating cancers using oral formulations of cytidine analogs |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9125884B2 (enExample) |
| EP (1) | EP2773322A1 (enExample) |
| JP (1) | JP6162709B2 (enExample) |
| KR (1) | KR20140088603A (enExample) |
| CN (1) | CN104168884A (enExample) |
| AU (1) | AU2012318239B2 (enExample) |
| BR (1) | BR112014010417A2 (enExample) |
| CA (1) | CA2853949A1 (enExample) |
| EA (1) | EA201490911A1 (enExample) |
| HK (1) | HK1200716A1 (enExample) |
| IL (1) | IL232268A0 (enExample) |
| MX (1) | MX2014005314A (enExample) |
| PH (1) | PH12014500965A1 (enExample) |
| SG (1) | SG11201401946QA (enExample) |
| TW (2) | TWI558401B (enExample) |
| WO (1) | WO2013067043A1 (enExample) |
| ZA (2) | ZA201403106B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY161593A (en) | 2008-05-15 | 2017-04-28 | Celgene Corp | Oral formulations of cytidine analogs and methods of use thereof |
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| KR101987861B1 (ko) | 2011-11-03 | 2019-06-11 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 |
| EP3094744A1 (en) * | 2014-01-15 | 2016-11-23 | Apogenix AG | Method of predicting the responsiveness of a cancer disease to treatment on the basis of dna methylation |
| WO2015195634A1 (en) * | 2014-06-17 | 2015-12-23 | Celgne Corporation | Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine |
| WO2015195786A2 (en) * | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| CN104147036B (zh) * | 2014-08-24 | 2017-04-05 | 浙江大学 | 地西他滨和奥沙利铂在制备治疗肾细胞癌组合药物中应用 |
| TWI690333B (zh) * | 2015-06-29 | 2020-04-11 | 日商大賽璐股份有限公司 | 易服用性固態製劑（有核錠）之製造方法及易服用性固態製劑 |
| TWI716415B (zh) * | 2015-06-29 | 2021-01-21 | 日商大賽璐股份有限公司 | 易服用性固態製劑之製造方法及易服用性固態製劑 |
| CN108472280A (zh) * | 2015-09-01 | 2018-08-31 | 布罗德研究所股份有限公司 | 用于治疗或者预防血液癌症的化合物和方法 |
| EP3442584B1 (en) | 2016-03-15 | 2021-07-28 | Seagen Inc. | Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors |
| WO2017180768A1 (en) * | 2016-04-15 | 2017-10-19 | Seattle Genetics, Inc. | Combinations of cd33 antibody drug conjugates with hypomethylating agents |
| US11110179B2 (en) | 2016-06-03 | 2021-09-07 | Seagen Inc. | Combination of CD33 antibody drug conjugates with chemotherapeutic agents |
| IL262565B (en) * | 2016-06-06 | 2022-08-01 | Celgene Corp | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| US11191771B2 (en) | 2016-06-09 | 2021-12-07 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with FLT3 inhibitors |
| WO2018009705A1 (en) * | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Liver cancer methylation markers and uses thereof |
| US12016902B2 (en) | 2017-04-04 | 2024-06-25 | Loma Linda University | Biologic for the treatment of cancer |
| GB201819453D0 (en) * | 2018-11-29 | 2019-01-16 | Ucl Business Plc | Molecular signature |
| CA3156376A1 (en) | 2019-11-04 | 2021-05-14 | Fei Huang | Use of a janus kinase inhibitor and a telomerase inhibitor for the treatment of myeloproliferative neoplasms |
| KR20230113186A (ko) * | 2022-01-21 | 2023-07-28 | 주식회사 피노바이오 | 5-아자-4'-티오-2'-데옥시사이티딘을 함유하는 경구용 제형 및 이의 제조방법 |
| WO2024191252A1 (ko) * | 2023-03-14 | 2024-09-19 | 주식회사 피노바이오 | 골수에 작용하는 5-아자-4'-티오-2'-데옥시사이티딘의 최고 혈중농도를 정교하게 제어가능한 경구용 제형 |
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| KR20150136137A (ko) | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
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-
2012
- 2012-10-31 SG SG11201401946QA patent/SG11201401946QA/en unknown
- 2012-10-31 EA EA201490911A patent/EA201490911A1/ru unknown
- 2012-10-31 MX MX2014005314A patent/MX2014005314A/es not_active Application Discontinuation
- 2012-10-31 CA CA2853949A patent/CA2853949A1/en not_active Withdrawn
- 2012-10-31 BR BRBR112014010417-4A patent/BR112014010417A2/pt not_active Application Discontinuation
- 2012-10-31 TW TW101140377A patent/TWI558401B/zh not_active IP Right Cessation
- 2012-10-31 KR KR1020147014861A patent/KR20140088603A/ko not_active Withdrawn
- 2012-10-31 US US13/665,778 patent/US9125884B2/en not_active Expired - Fee Related
- 2012-10-31 EP EP12783817.5A patent/EP2773322A1/en not_active Withdrawn
- 2012-10-31 PH PH1/2014/500965A patent/PH12014500965A1/en unknown
- 2012-10-31 HK HK15101233.8A patent/HK1200716A1/xx unknown
- 2012-10-31 WO PCT/US2012/062845 patent/WO2013067043A1/en not_active Ceased
- 2012-10-31 TW TW105130025A patent/TW201700103A/zh unknown
- 2012-10-31 CN CN201280065749.3A patent/CN104168884A/zh active Pending
- 2012-10-31 AU AU2012318239A patent/AU2012318239B2/en not_active Ceased
- 2012-10-31 JP JP2014540046A patent/JP6162709B2/ja active Active
-
2014
- 2014-04-27 IL IL232268A patent/IL232268A0/en unknown
- 2014-04-29 ZA ZA2014/03106A patent/ZA201403106B/en unknown
-
2015
- 2015-04-16 US US14/688,623 patent/US9693987B2/en active Active
- 2015-04-28 ZA ZA2015/02909A patent/ZA201502909B/en unknown
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|---|---|
| EP2773322A1 (en) | 2014-09-10 |
| TW201325598A (zh) | 2013-07-01 |
| MX2014005314A (es) | 2014-09-08 |
| JP6162709B2 (ja) | 2017-07-12 |
| AU2012318239A1 (en) | 2013-05-16 |
| US9125884B2 (en) | 2015-09-08 |
| KR20140088603A (ko) | 2014-07-10 |
| US20150216886A1 (en) | 2015-08-06 |
| CN104168884A (zh) | 2014-11-26 |
| BR112014010417A2 (pt) | 2014-11-18 |
| NZ624323A (en) | 2016-07-29 |
| SG11201401946QA (en) | 2014-05-29 |
| TW201700103A (zh) | 2017-01-01 |
| JP2014532704A (ja) | 2014-12-08 |
| CA2853949A1 (en) | 2013-05-10 |
| PH12014500965A1 (en) | 2014-06-30 |
| US9693987B2 (en) | 2017-07-04 |
| EA201490911A1 (ru) | 2014-09-30 |
| TWI558401B (zh) | 2016-11-21 |
| IL232268A0 (en) | 2014-06-30 |
| ZA201502909B (en) | 2016-11-30 |
| US20130109644A1 (en) | 2013-05-02 |
| HK1200716A1 (zh) | 2015-08-14 |
| AU2012318239B2 (en) | 2015-07-09 |
| WO2013067043A1 (en) | 2013-05-10 |
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