ZA201204938B - Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4(4-cyclopropylnaphtalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate,and uses thereof - Google Patents

Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4(4-cyclopropylnaphtalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate,and uses thereof

Info

Publication number
ZA201204938B
ZA201204938B ZA2012/04938A ZA201204938A ZA201204938B ZA 201204938 B ZA201204938 B ZA 201204938B ZA 2012/04938 A ZA2012/04938 A ZA 2012/04938A ZA 201204938 A ZA201204938 A ZA 201204938A ZA 201204938 B ZA201204938 B ZA 201204938B
Authority
ZA
South Africa
Prior art keywords
cyclopropylnaphtalen
ylthio
triazol
polymorphic
bromo
Prior art date
Application number
ZA2012/04938A
Other languages
English (en)
Inventor
Irina Zamansky
Jean-Luc Girardet
Gabriel Galvin
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of ZA201204938B publication Critical patent/ZA201204938B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2012/04938A 2010-01-08 2012-07-02 Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4(4-cyclopropylnaphtalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate,and uses thereof ZA201204938B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29360210P 2010-01-08 2010-01-08
PCT/US2011/020233 WO2011085009A2 (en) 2010-01-08 2011-01-05 Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate, and uses thereof

Publications (1)

Publication Number Publication Date
ZA201204938B true ZA201204938B (en) 2014-12-23

Family

ID=44306123

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/04938A ZA201204938B (en) 2010-01-08 2012-07-02 Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4(4-cyclopropylnaphtalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate,and uses thereof

Country Status (20)

Country Link
US (2) US8524754B2 (enExample)
EP (1) EP2521716B1 (enExample)
JP (1) JP5696346B2 (enExample)
KR (1) KR20120104627A (enExample)
CN (1) CN102741234B (enExample)
AU (1) AU2011203708B2 (enExample)
BR (1) BR112012016795A2 (enExample)
CA (1) CA2785200C (enExample)
CL (1) CL2012001841A1 (enExample)
CO (1) CO6561780A2 (enExample)
EA (1) EA020183B1 (enExample)
ES (1) ES2563207T3 (enExample)
MX (1) MX2012007925A (enExample)
MY (1) MY161482A (enExample)
NZ (1) NZ600984A (enExample)
PH (1) PH12012501391A1 (enExample)
SG (1) SG182404A1 (enExample)
TW (1) TWI451867B (enExample)
WO (1) WO2011085009A2 (enExample)
ZA (1) ZA201204938B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560642A4 (en) * 2010-03-30 2013-12-18 Ardea Biosciences Inc TREATMENT OF GICHT
ES2670700T3 (es) * 2010-06-15 2018-05-31 Ardea Biosciences, Inc. Tratamiento de gota e hiperuricemia
MY172534A (en) * 2010-12-30 2019-11-29 Ardea Biosciences Inc Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid and uses thereof
ES2704233T3 (es) 2011-11-03 2019-03-15 Ardea Biosciences Inc Compuesto de piridina 3,4-di-sustituido, procedimientos de uso y composiciones que comprenden el mismo
AR091651A1 (es) * 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico
CN103524440B (zh) * 2013-10-15 2015-09-09 苏州鹏旭医药科技有限公司 痛风治疗药Lesinurad的制备方法及Lesinurad中间体
CN103613552A (zh) * 2013-12-02 2014-03-05 苏州晶云药物科技有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法
CN103588716A (zh) * 2013-11-22 2014-02-19 苏州晶云药物科技有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的新晶型及其制备方法
CA2931430A1 (en) * 2013-11-22 2015-05-28 Crystal Pharmatech Co., Ltd. Crystalline forms of lesinurad and its sodium salt
WO2015095703A1 (en) 2013-12-20 2015-06-25 Crystal Pharmatech, Inc. Novel salts and co-crystals of lesinurad
CN103626710A (zh) * 2013-12-20 2014-03-12 苏州晶云药物科技有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的共晶及其制备方法
CN103755651A (zh) * 2013-12-23 2014-04-30 苏州晶云药物科技有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法
CN105315218A (zh) * 2014-07-17 2016-02-10 天津药物研究院 一种制备lesinurad中间体1-萘基三唑硫酮的方法
CN105622427A (zh) * 2014-10-31 2016-06-01 天津药物研究院有限公司 一种制备lesinurad中间体4-环丙基-1-萘胺的方法
CN105820130B (zh) * 2015-01-08 2018-06-22 天津药物研究院有限公司 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
CN105985296B (zh) * 2015-02-13 2018-10-16 天津药物研究院有限公司 一种可以工业化的lesinurad中间体1-萘基三唑硫酮的精制工艺
CN105622531A (zh) 2015-04-03 2016-06-01 南京明德新药研发股份有限公司 轴手性异构体及其制备方法和制药用途
CN104817509B (zh) * 2015-04-13 2019-05-17 安徽省逸欣铭医药科技有限公司 Lesinurad类似物及其制备方法和医药用途
CN106187926B (zh) * 2015-04-30 2018-11-27 天津药物研究院有限公司 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
EP3112334A1 (en) 2015-06-29 2017-01-04 DPx Fine Chemicals Austria GmbH & CoKG Process for manufacturing 1-cyclopropyl-naphthalenes
CN104987311A (zh) * 2015-06-30 2015-10-21 安徽万邦医药科技有限公司 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯
CN105017168A (zh) * 2015-07-01 2015-11-04 安徽万邦医药科技有限公司 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法
CN105153056A (zh) * 2015-07-01 2015-12-16 安徽万邦医药科技有限公司 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法
WO2017036884A1 (en) 2015-08-28 2017-03-09 Sandoz Ag A lesinurad, free form / lesinurad ethyl ester co-crystal
CN105566237B (zh) * 2016-03-01 2018-05-18 山东大学 一种治疗痛风的三唑巯乙酸类化合物的制备方法
CN107337649B (zh) * 2016-04-29 2020-10-16 四川科伦药物研究院有限公司 一种乙酸钠水合物无定型及其制备方法和用途
EP3281941B1 (en) 2016-08-11 2019-07-24 Zentiva K.S. Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid
WO2018085932A1 (en) 2016-11-10 2018-05-17 Apotex Inc. Novel crystalline forms of lesinurad
CN106632108A (zh) * 2016-12-14 2017-05-10 湖南欧亚生物有限公司 一种来司诺雷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
ME01512B (me) 2004-08-25 2014-04-20 Ardea Biosciences Inc S-triazolil alfa-merkaptoacetanilida kao inhibitori HIV reversne transkriptaze
BRPI0819847B1 (pt) 2007-11-27 2022-01-11 Ardea Biosciences, Inc Compostos e composições
CN102186832B (zh) * 2008-09-04 2014-04-02 亚德生化公司 调节尿酸含量的化合物、组合物及其使用方法
MY172534A (en) 2010-12-30 2019-11-29 Ardea Biosciences Inc Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid and uses thereof

Also Published As

Publication number Publication date
HK1172622A1 (zh) 2013-04-26
EA201270676A1 (ru) 2013-01-30
EP2521716A4 (en) 2013-07-10
CO6561780A2 (es) 2012-11-15
EP2521716B1 (en) 2015-12-30
PH12012501391A1 (en) 2012-10-29
JP5696346B2 (ja) 2015-04-08
EA020183B1 (ru) 2014-09-30
JP2013516473A (ja) 2013-05-13
US8524754B2 (en) 2013-09-03
SG182404A1 (en) 2012-08-30
WO2011085009A2 (en) 2011-07-14
AU2011203708B2 (en) 2013-08-01
US20120129903A1 (en) 2012-05-24
CN102741234B (zh) 2015-11-25
MX2012007925A (es) 2012-08-03
CA2785200A1 (en) 2011-07-14
MY161482A (en) 2017-04-14
CL2012001841A1 (es) 2013-08-23
TWI451867B (zh) 2014-09-11
KR20120104627A (ko) 2012-09-21
WO2011085009A3 (en) 2011-11-10
CA2785200C (en) 2015-02-24
NZ600984A (en) 2013-10-25
BR112012016795A2 (pt) 2020-09-01
ES2563207T3 (es) 2016-03-11
AU2011203708A1 (en) 2012-07-26
TW201143767A (en) 2011-12-16
CN102741234A (zh) 2012-10-17
EP2521716A2 (en) 2012-11-14
US20130345271A1 (en) 2013-12-26

Similar Documents

Publication Publication Date Title
LT2658846T (lt) 2-(5-brom-4-(4-ciklopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acto rūgšties polimorfinės formos ir jų panaudojimas
EP2521716A4 (en) POLYMORPHIC, CRYSTALLINE AND MESOPHASIC FORMS OF SODIUM-2- (5-BROM-4- (4-CYCLOPROPYLNAPHTHALEN-1-YL-) 4H-1,2,4-TRIAZOL-3-YLTHIO-) ACETATE AND USES THEREOF
IL266563A (en) Heterocyclic compounds used as pdk1 inhibitors
ZA201409489B (en) Manufacture of 2- (5- bromo-4-(4-cyclopropylnaphthalen-1-yl) -4h-1,2,4-triazol-3-ylthio) acetic acid
ZA201303599B (en) Crystalline forms of 5-chloro-n2-(2-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine2-,4-diamine
IL216648A0 (en) Crystalline forms of febuxostat
IL223329A (en) Benzodioxole or benzodioxoxine heterocyclic compounds as phosphodiesterase inhibitors
EP2632461A4 (en) Isoindolinone PDE10 INHIBITORS
ZA201003909B (en) Crystalline 2-(4-cyclopropanesulphonyl-phenyl)-n-pyrazin-2-yl-3-(tetrahydopyran-4-yl)-propionamide
EP2475701A4 (en) NEW THIOVER BINDINGS AND METHOD FOR THEIR MANUFACTURE
GB0902406D0 (en) Crystalline polymorphic form
HUE037631T2 (hu) A 6-(1H-imidazol-1-il)-2-fenil-kinazolin kristályformái
LT3395796T (lt) (3s,3s') 4,4'-disulfandiil-bis-(3-aminobutan-1-sulfonrūgšties) kristalinė trihidrato forma
ZA201109045B (en) Crystalline form of pemirolast
IT1395118B1 (it) Procedimento per la preparazione di dexlansoprazolo cristallino
EP2632907A4 (en) PROCESS FOR THE PREPARATION OF 2- (2-HYDROXYPHENYL) -BENZ [1,3] OXAZIN-4-ONE AND USE THEREOF FOR THE PREPARATION OF 4- [3,5-BIS (2-HYDROXYPHENYL) -1H-1 ACID 2,4-TRIAZOL-1-YL] -BENZOIC
GB0710680D0 (en) Novel crystalline form of olmesartan medoxmil
IL195092A0 (en) Crystalline form of (s)-1-phenylethylammonium (r)-diphenyl-methanesulphinyl-acetate