ZA201201519B - Orally administerable pharmaceutical preparation containing insulin - Google Patents
Orally administerable pharmaceutical preparation containing insulinInfo
- Publication number
- ZA201201519B ZA201201519B ZA2012/01519A ZA201201519A ZA201201519B ZA 201201519 B ZA201201519 B ZA 201201519B ZA 2012/01519 A ZA2012/01519 A ZA 2012/01519A ZA 201201519 A ZA201201519 A ZA 201201519A ZA 201201519 B ZA201201519 B ZA 201201519B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical preparation
- preparation containing
- containing insulin
- orally administerable
- administerable pharmaceutical
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900482A HUP0900482A2 (en) | 2009-08-03 | 2009-08-03 | Pharmaceutical formulation for oral administration |
| PCT/IB2010/053499 WO2011015984A1 (en) | 2009-08-03 | 2010-08-02 | Orally administerable pharmaceutical preparation containing insulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201201519B true ZA201201519B (en) | 2013-05-29 |
Family
ID=89989155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/01519A ZA201201519B (en) | 2009-08-03 | 2012-02-29 | Orally administerable pharmaceutical preparation containing insulin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120129769A1 (enExample) |
| EP (1) | EP2461820A1 (enExample) |
| JP (1) | JP2013501043A (enExample) |
| KR (1) | KR20120088660A (enExample) |
| CN (1) | CN102791282A (enExample) |
| AU (1) | AU2010280418B2 (enExample) |
| BR (1) | BR112012002413A2 (enExample) |
| CA (1) | CA2769620A1 (enExample) |
| HU (1) | HUP0900482A2 (enExample) |
| IL (1) | IL217856A0 (enExample) |
| MX (1) | MX2012001461A (enExample) |
| RU (1) | RU2012109006A (enExample) |
| UA (1) | UA106506C2 (enExample) |
| WO (1) | WO2011015984A1 (enExample) |
| ZA (1) | ZA201201519B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3070695C (en) * | 2011-06-29 | 2024-01-23 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| CN111065749B (zh) * | 2017-06-28 | 2024-06-28 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） | 用于确定发展1型糖尿病的风险的方法 |
| KR20240171428A (ko) | 2023-05-30 | 2024-12-09 | (주)네오비젼 | 당뇨병 치료를 위한 약물 방출 제어가 가능한 약물 전달용 콘택트렌즈 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172814A (en) | 1962-04-06 | 1965-03-09 | Jr Edgar A Ferguson | Oral blood sugar lowering compositions |
| JPS5428807A (en) | 1977-08-09 | 1979-03-03 | Hiroyuki Sumi | Oral insulin |
| IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| DE68909135T2 (de) | 1988-07-21 | 1994-04-07 | Hoffmann La Roche | Insulinzubereitung. |
| AU671964B2 (en) | 1991-12-05 | 1996-09-19 | Alfatec-Pharma Gmbh | Peroral administration form for peptidic medicaments, in particular insulin |
| JP3047948B2 (ja) * | 1992-12-07 | 2000-06-05 | 株式会社ツムラ | ペプチド類経鼻投与用組成物 |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| EP0803255A4 (en) * | 1994-06-03 | 1999-06-30 | Tsumura & Co | MEDICINAL COMPOSITION |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5970193A (en) | 1996-10-24 | 1999-10-19 | Nortel Networks Corporation | Data communications structures relating to data shelf configurations |
| BR9808466A (pt) | 1997-04-02 | 2001-08-07 | Purdue Research Foundation | Método para distribuição oral de proteìnas |
| WO2000033866A1 (en) | 1998-12-04 | 2000-06-15 | Provalis Uk Limited | Pharmaceutical compositions containing insulin |
| US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
| JP2006519253A (ja) | 2003-03-04 | 2006-08-24 | ザ・テクノロジー・デヴェロップメント・カンパニー・リミテッド | 長時間作用性注射用インスリン組成物およびその製造および使用方法 |
| JP5103748B2 (ja) * | 2005-02-16 | 2012-12-19 | 東レ株式会社 | 医薬組成物 |
| JP5222727B2 (ja) * | 2005-09-06 | 2013-06-26 | オーラメッド・ファーマスーティカルズ・インコーポレイテッド | タンパク質を経口投与するための方法及び組成物 |
| WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| CN101062408B (zh) * | 2006-04-27 | 2010-12-08 | 深圳市隆阳生物科技有限公司 | 口服胰岛素复合制剂及其制备方法 |
| JP2008266179A (ja) * | 2007-04-19 | 2008-11-06 | Fujifilm Corp | 経肺用組成物 |
| US20110144010A1 (en) * | 2007-06-01 | 2011-06-16 | Novo Nordisk A/S | Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier |
| US9186412B2 (en) * | 2008-08-18 | 2015-11-17 | Entera Bio Ltd. | Methods and compositions for oral administration of insulin |
-
2009
- 2009-08-03 HU HU0900482A patent/HUP0900482A2/hu unknown
-
2010
- 2010-08-02 WO PCT/IB2010/053499 patent/WO2011015984A1/en not_active Ceased
- 2010-08-02 EP EP10757272A patent/EP2461820A1/en not_active Withdrawn
- 2010-08-02 UA UAA201202346A patent/UA106506C2/uk unknown
- 2010-08-02 AU AU2010280418A patent/AU2010280418B2/en not_active Expired - Fee Related
- 2010-08-02 MX MX2012001461A patent/MX2012001461A/es not_active Application Discontinuation
- 2010-08-02 KR KR1020127005524A patent/KR20120088660A/ko not_active Withdrawn
- 2010-08-02 CN CN201080038764XA patent/CN102791282A/zh active Pending
- 2010-08-02 BR BR112012002413A patent/BR112012002413A2/pt not_active IP Right Cessation
- 2010-08-02 JP JP2012523416A patent/JP2013501043A/ja active Pending
- 2010-08-02 RU RU2012109006/15A patent/RU2012109006A/ru unknown
- 2010-08-02 US US13/387,212 patent/US20120129769A1/en not_active Abandoned
- 2010-08-02 CA CA2769620A patent/CA2769620A1/en not_active Abandoned
-
2012
- 2012-01-31 IL IL217856A patent/IL217856A0/en unknown
- 2012-02-29 ZA ZA2012/01519A patent/ZA201201519B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2769620A1 (en) | 2011-02-10 |
| JP2013501043A (ja) | 2013-01-10 |
| HU0900482D0 (en) | 2009-10-28 |
| US20120129769A1 (en) | 2012-05-24 |
| MX2012001461A (es) | 2012-05-22 |
| BR112012002413A2 (pt) | 2016-03-01 |
| KR20120088660A (ko) | 2012-08-08 |
| IL217856A0 (en) | 2012-03-29 |
| AU2010280418A1 (en) | 2012-03-22 |
| WO2011015984A1 (en) | 2011-02-10 |
| CN102791282A (zh) | 2012-11-21 |
| UA106506C2 (uk) | 2014-09-10 |
| EP2461820A1 (en) | 2012-06-13 |
| RU2012109006A (ru) | 2013-09-10 |
| HUP0900482A2 (en) | 2011-03-28 |
| AU2010280418B2 (en) | 2015-04-09 |
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