JP2013501043A - 経口投与可能な医薬製剤 - Google Patents
経口投与可能な医薬製剤 Download PDFInfo
- Publication number
- JP2013501043A JP2013501043A JP2012523416A JP2012523416A JP2013501043A JP 2013501043 A JP2013501043 A JP 2013501043A JP 2012523416 A JP2012523416 A JP 2012523416A JP 2012523416 A JP2012523416 A JP 2012523416A JP 2013501043 A JP2013501043 A JP 2013501043A
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- JP
- Japan
- Prior art keywords
- insulin
- type
- pharmaceutical formulation
- aminocaproic acid
- casein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0900482 | 2009-08-03 | ||
| HU0900482A HUP0900482A2 (en) | 2009-08-03 | 2009-08-03 | Pharmaceutical formulation for oral administration |
| PCT/IB2010/053499 WO2011015984A1 (en) | 2009-08-03 | 2010-08-02 | Orally administerable pharmaceutical preparation containing insulin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501043A true JP2013501043A (ja) | 2013-01-10 |
| JP2013501043A5 JP2013501043A5 (enExample) | 2013-07-25 |
Family
ID=89989155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523416A Pending JP2013501043A (ja) | 2009-08-03 | 2010-08-02 | 経口投与可能な医薬製剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120129769A1 (enExample) |
| EP (1) | EP2461820A1 (enExample) |
| JP (1) | JP2013501043A (enExample) |
| KR (1) | KR20120088660A (enExample) |
| CN (1) | CN102791282A (enExample) |
| AU (1) | AU2010280418B2 (enExample) |
| BR (1) | BR112012002413A2 (enExample) |
| CA (1) | CA2769620A1 (enExample) |
| HU (1) | HUP0900482A2 (enExample) |
| IL (1) | IL217856A0 (enExample) |
| MX (1) | MX2012001461A (enExample) |
| RU (1) | RU2012109006A (enExample) |
| UA (1) | UA106506C2 (enExample) |
| WO (1) | WO2011015984A1 (enExample) |
| ZA (1) | ZA201201519B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2726091T3 (pl) * | 2011-06-29 | 2020-08-10 | Rani Therapeutics, Llc | Preparaty lecznicze dostarczane do kanału przewodu jelitowego za pomocą połykalnego urządzenia dostarczającego lek |
| CA3067713A1 (en) * | 2017-06-28 | 2019-01-03 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Method for determining the risk to develop type 1 diabetes |
| KR20240171428A (ko) | 2023-05-30 | 2024-12-09 | (주)네오비젼 | 당뇨병 치료를 위한 약물 방출 제어가 가능한 약물 전달용 콘택트렌즈 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033474A1 (en) * | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
| JP2006257074A (ja) * | 2005-02-16 | 2006-09-28 | Toray Ind Inc | 医薬組成物 |
| CN101062408A (zh) * | 2006-04-27 | 2007-10-31 | 深圳市隆阳生物科技有限公司 | 口服胰岛素复合制剂及其制备方法 |
| JP2008266179A (ja) * | 2007-04-19 | 2008-11-06 | Fujifilm Corp | 経肺用組成物 |
| WO2008145728A1 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
| JP2009507067A (ja) * | 2005-09-06 | 2009-02-19 | オーラメッド・ファーマスーティカルズ・インコーポレイテッド | タンパク質を経口投与するための方法及び組成物 |
| JP2012500254A (ja) * | 2008-08-18 | 2012-01-05 | オラムド エルティーディー． | タンパク質の経口投与用の方法および組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172814A (en) | 1962-04-06 | 1965-03-09 | Jr Edgar A Ferguson | Oral blood sugar lowering compositions |
| JPS5428807A (en) | 1977-08-09 | 1979-03-03 | Hiroyuki Sumi | Oral insulin |
| IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| ES2045276T3 (es) | 1988-07-21 | 1994-01-16 | Hoffmann La Roche | Preparacion de insulina |
| CA2125284C (en) | 1991-12-05 | 2000-06-20 | Jens-Christian Wunderlich | Peroral administration form for peptidic medicaments, in particular insulin |
| JP3047948B2 (ja) * | 1992-12-07 | 2000-06-05 | 株式会社ツムラ | ペプチド類経鼻投与用組成物 |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5970193A (en) | 1996-10-24 | 1999-10-19 | Nortel Networks Corporation | Data communications structures relating to data shelf configurations |
| WO1998043615A1 (en) | 1997-04-02 | 1998-10-08 | Purdue Research Foundation | Method for oral delivery of proteins |
| WO2000033866A1 (en) | 1998-12-04 | 2000-06-15 | Provalis Uk Limited | Pharmaceutical compositions containing insulin |
| US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
| KR20060015469A (ko) | 2003-03-04 | 2006-02-17 | 더 테크놀로지 디벨로프먼트 컴퍼니 리미티드 | 경구용 인슐린 조성물 및 그 제조방법 및 사용방법 |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
-
2009
- 2009-08-03 HU HU0900482A patent/HUP0900482A2/hu unknown
-
2010
- 2010-08-02 WO PCT/IB2010/053499 patent/WO2011015984A1/en not_active Ceased
- 2010-08-02 US US13/387,212 patent/US20120129769A1/en not_active Abandoned
- 2010-08-02 BR BR112012002413A patent/BR112012002413A2/pt not_active IP Right Cessation
- 2010-08-02 KR KR1020127005524A patent/KR20120088660A/ko not_active Withdrawn
- 2010-08-02 RU RU2012109006/15A patent/RU2012109006A/ru unknown
- 2010-08-02 CA CA2769620A patent/CA2769620A1/en not_active Abandoned
- 2010-08-02 CN CN201080038764XA patent/CN102791282A/zh active Pending
- 2010-08-02 MX MX2012001461A patent/MX2012001461A/es not_active Application Discontinuation
- 2010-08-02 JP JP2012523416A patent/JP2013501043A/ja active Pending
- 2010-08-02 AU AU2010280418A patent/AU2010280418B2/en not_active Expired - Fee Related
- 2010-08-02 UA UAA201202346A patent/UA106506C2/uk unknown
- 2010-08-02 EP EP10757272A patent/EP2461820A1/en not_active Withdrawn
-
2012
- 2012-01-31 IL IL217856A patent/IL217856A0/en unknown
- 2012-02-29 ZA ZA2012/01519A patent/ZA201201519B/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033474A1 (en) * | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
| JP2006257074A (ja) * | 2005-02-16 | 2006-09-28 | Toray Ind Inc | 医薬組成物 |
| JP2009507067A (ja) * | 2005-09-06 | 2009-02-19 | オーラメッド・ファーマスーティカルズ・インコーポレイテッド | タンパク質を経口投与するための方法及び組成物 |
| CN101062408A (zh) * | 2006-04-27 | 2007-10-31 | 深圳市隆阳生物科技有限公司 | 口服胰岛素复合制剂及其制备方法 |
| JP2008266179A (ja) * | 2007-04-19 | 2008-11-06 | Fujifilm Corp | 経肺用組成物 |
| WO2008145728A1 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
| JP2012500254A (ja) * | 2008-08-18 | 2012-01-05 | オラムド エルティーディー． | タンパク質の経口投与用の方法および組成物 |
Non-Patent Citations (1)
| Title |
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| JPN6014030511; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｍｏｌｅｃｕｌａｒ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．９， Ｎｏ．１２, 2008, ｐ．２３７６-２３８７ * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012001461A (es) | 2012-05-22 |
| ZA201201519B (en) | 2013-05-29 |
| US20120129769A1 (en) | 2012-05-24 |
| UA106506C2 (uk) | 2014-09-10 |
| WO2011015984A1 (en) | 2011-02-10 |
| BR112012002413A2 (pt) | 2016-03-01 |
| RU2012109006A (ru) | 2013-09-10 |
| HUP0900482A2 (en) | 2011-03-28 |
| IL217856A0 (en) | 2012-03-29 |
| HU0900482D0 (en) | 2009-10-28 |
| AU2010280418A1 (en) | 2012-03-22 |
| EP2461820A1 (en) | 2012-06-13 |
| KR20120088660A (ko) | 2012-08-08 |
| CA2769620A1 (en) | 2011-02-10 |
| AU2010280418B2 (en) | 2015-04-09 |
| CN102791282A (zh) | 2012-11-21 |
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