ZA201107011B - Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration - Google Patents
Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administrationInfo
- Publication number
- ZA201107011B ZA201107011B ZA2011/07011A ZA201107011A ZA201107011B ZA 201107011 B ZA201107011 B ZA 201107011B ZA 2011/07011 A ZA2011/07011 A ZA 2011/07011A ZA 201107011 A ZA201107011 A ZA 201107011A ZA 201107011 B ZA201107011 B ZA 201107011B
- Authority
- ZA
- South Africa
- Prior art keywords
- vasoconstrictor
- tetracaine
- intranasal administration
- dental anesthetic
- anesthetic
- Prior art date
Links
- 230000003444 anaesthetic effect Effects 0.000 title 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 title 1
- 229960002372 tetracaine Drugs 0.000 title 1
- 239000005526 vasoconstrictor agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16668009P | 2009-04-03 | 2009-04-03 | |
| PCT/US2010/001002 WO2010114622A1 (en) | 2009-04-03 | 2010-04-02 | Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201107011B true ZA201107011B (en) | 2014-03-26 |
Family
ID=42164462
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/07011A ZA201107011B (en) | 2009-04-03 | 2011-09-26 | Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration |
| ZA2013/09321A ZA201309321B (en) | 2009-04-03 | 2013-12-11 | Dental anesthetic comprising tetracaine and a vasoconstrictor fpr intranasal administration |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/09321A ZA201309321B (en) | 2009-04-03 | 2013-12-11 | Dental anesthetic comprising tetracaine and a vasoconstrictor fpr intranasal administration |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US8580282B2 (https=) |
| EP (1) | EP2413899B1 (https=) |
| JP (3) | JP5788864B2 (https=) |
| KR (2) | KR20170026639A (https=) |
| CN (2) | CN102421416B (https=) |
| AU (2) | AU2010232995C1 (https=) |
| BR (1) | BRPI1010303A2 (https=) |
| CA (1) | CA2757032C (https=) |
| DK (1) | DK2413899T3 (https=) |
| EA (1) | EA024184B1 (https=) |
| ES (1) | ES2861064T3 (https=) |
| IL (1) | IL215489A0 (https=) |
| MX (1) | MX2011010445A (https=) |
| NZ (2) | NZ612063A (https=) |
| PL (1) | PL2413899T3 (https=) |
| PT (1) | PT2413899T (https=) |
| WO (1) | WO2010114622A1 (https=) |
| ZA (2) | ZA201107011B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170026639A (ko) | 2009-04-03 | 2017-03-08 | 세인트 레나투스, 엘엘씨 | 비강 투여를 위한 테트라카인 및 혈관수축제를 포함하는 치과용 마취제 |
| EP2903604A1 (en) * | 2012-09-28 | 2015-08-12 | St. Renatus, LLC | Pharmaceutical composition comprising benzyl alcohol for the treatment of migraines |
| US20180193462A1 (en) * | 2014-01-01 | 2018-07-12 | Real Time Imaging Technologies, Llc | Improved local anesthetic solution for dental and/or contrast media use |
| AU2015277272A1 (en) * | 2014-06-16 | 2017-01-12 | Loewi LLC | Methods of anesthetizing nerve tissue in the trigeminal nerve pathway and medical uses thereof |
| CN107249568A (zh) * | 2014-12-23 | 2017-10-13 | 圣雷纳图斯有限责任公司 | 基于丁卡因的麻醉药 |
| EP3244800A1 (en) | 2015-01-12 | 2017-11-22 | Real Time Imaging Technologies, LLC | Low-dose x-ray imaging system |
| US10039830B2 (en) * | 2016-03-04 | 2018-08-07 | Cetylite Industries, Inc. | Topical anesthetic composition |
| US20170360718A1 (en) * | 2016-06-01 | 2017-12-21 | St. Renatus, Llc | Intranasal dental anesthetic |
| EP3897603A4 (en) | 2018-12-19 | 2022-09-14 | Grace Therapeutics Inc. | THERAPEUTIC COMPOSITION OF INTRANASAL LIDOCAINE |
| CN111494310A (zh) * | 2020-04-29 | 2020-08-07 | 周晓玲 | 一种局部麻醉药物的制备及使用方法 |
| WO2024151854A1 (en) * | 2023-01-13 | 2024-07-18 | Smilanich Michael D | Composition for local anesthesia and uses thereof |
| GB2628149A (en) * | 2023-03-16 | 2024-09-18 | Lee Nathaniel Wurie | Nasal spray for performing sphenopalatine ganglion block |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3832460A (en) * | 1971-03-19 | 1974-08-27 | C Kosti | Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue |
| US5209724A (en) | 1988-04-11 | 1993-05-11 | Dhaliwal Avtar S | Composite anesthetic article and method of use |
| AU4673993A (en) | 1992-07-28 | 1994-02-14 | Procter & Gamble Company, The | Pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether |
| WO1995013810A1 (en) | 1993-11-19 | 1995-05-26 | Schering-Plough Healthcare Products Incorporated | Nasal spray compositions containing oxymetazoline |
| US5585398A (en) * | 1994-07-15 | 1996-12-17 | Ernst; Amy A. | Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use |
| US6075059A (en) | 1999-02-24 | 2000-06-13 | The Ohio State University | Compositions for dental anesthesia |
| US20040131665A1 (en) * | 1999-10-22 | 2004-07-08 | Wepfer Scott T. | Topical anesthetic formulation |
| US6413499B1 (en) * | 2000-01-06 | 2002-07-02 | Bryan M. Clay | Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic |
| US20040045546A1 (en) | 2002-09-05 | 2004-03-11 | Peirce Management, Llc | Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use |
| JP4591746B2 (ja) | 2002-12-03 | 2010-12-01 | 大正製薬株式会社 | 難溶性抗ウイルス成分含有水溶性外用剤組成物 |
| ES2223277B1 (es) * | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
| EA009669B1 (ru) | 2004-01-01 | 2008-02-28 | Панацея Биотек Лтд. | Фармацевтические композиции, содержащие экстракт euphorbia prostrata |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| US20070154402A1 (en) | 2005-10-24 | 2007-07-05 | Collegium Pharmaceutical, Inc. | Topical Pharmaceutical Foam Composition |
| US9252862B2 (en) | 2008-09-17 | 2016-02-02 | Qualcomm Incorporated | MIMO preamble for initial access with an unknown number of transmit antennas |
| KR20170026639A (ko) * | 2009-04-03 | 2017-03-08 | 세인트 레나투스, 엘엘씨 | 비강 투여를 위한 테트라카인 및 혈관수축제를 포함하는 치과용 마취제 |
-
2010
- 2010-04-02 KR KR1020177005466A patent/KR20170026639A/ko not_active Ceased
- 2010-04-02 PT PT107141194T patent/PT2413899T/pt unknown
- 2010-04-02 KR KR1020117026165A patent/KR101747979B1/ko not_active Expired - Fee Related
- 2010-04-02 ES ES10714119T patent/ES2861064T3/es active Active
- 2010-04-02 MX MX2011010445A patent/MX2011010445A/es active IP Right Grant
- 2010-04-02 JP JP2012503429A patent/JP5788864B2/ja not_active Expired - Fee Related
- 2010-04-02 CN CN201080020599.5A patent/CN102421416B/zh not_active Expired - Fee Related
- 2010-04-02 WO PCT/US2010/001002 patent/WO2010114622A1/en not_active Ceased
- 2010-04-02 EP EP10714119.4A patent/EP2413899B1/en active Active
- 2010-04-02 PL PL10714119T patent/PL2413899T3/pl unknown
- 2010-04-02 NZ NZ612063A patent/NZ612063A/en not_active IP Right Cessation
- 2010-04-02 CN CN201410169695.6A patent/CN103932973B/zh not_active Expired - Fee Related
- 2010-04-02 BR BRPI1010303A patent/BRPI1010303A2/pt not_active IP Right Cessation
- 2010-04-02 US US13/262,704 patent/US8580282B2/en not_active Expired - Fee Related
- 2010-04-02 EA EA201171215A patent/EA024184B1/ru not_active IP Right Cessation
- 2010-04-02 CA CA2757032A patent/CA2757032C/en active Active
- 2010-04-02 NZ NZ595376A patent/NZ595376A/xx unknown
- 2010-04-02 DK DK10714119.4T patent/DK2413899T3/da active
- 2010-04-02 AU AU2010232995A patent/AU2010232995C1/en not_active Ceased
-
2011
- 2011-09-26 ZA ZA2011/07011A patent/ZA201107011B/en unknown
- 2011-10-02 IL IL215489A patent/IL215489A0/en unknown
-
2013
- 2013-09-13 US US14/027,033 patent/US9308191B2/en not_active Expired - Fee Related
- 2013-12-11 ZA ZA2013/09321A patent/ZA201309321B/en unknown
-
2014
- 2014-10-15 JP JP2014210422A patent/JP2015034167A/ja not_active Withdrawn
-
2015
- 2015-10-13 AU AU2015242984A patent/AU2015242984B2/en not_active Expired - Fee Related
-
2016
- 2016-03-02 US US15/058,324 patent/US9855247B2/en active Active
- 2016-11-15 JP JP2016222091A patent/JP2017031226A/ja active Pending
-
2017
- 2017-04-18 US US15/490,011 patent/US10456377B2/en active Active
- 2017-04-27 US US15/498,991 patent/US10420750B2/en active Active
- 2017-04-27 US US15/498,986 patent/US20170326111A1/en not_active Abandoned
-
2020
- 2020-05-12 US US16/872,657 patent/US20200268715A1/en not_active Abandoned
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