ZA200904031B - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
ZA200904031B
ZA200904031B ZA200904031A ZA200904031A ZA200904031B ZA 200904031 B ZA200904031 B ZA 200904031B ZA 200904031 A ZA200904031 A ZA 200904031A ZA 200904031 A ZA200904031 A ZA 200904031A ZA 200904031 B ZA200904031 B ZA 200904031B
Authority
ZA
South Africa
Prior art keywords
chemical compounds
potency
phosphoramidate
enhanced
nucleoside
Prior art date
Application number
ZA200904031A
Other languages
English (en)
Inventor
Christopher Mcguigan
Plinio Perrone
Johan Neyts
Original Assignee
Univ Cardiff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff filed Critical Univ Cardiff
Publication of ZA200904031B publication Critical patent/ZA200904031B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA200904031A 2006-11-24 2009-06-10 Chemical compounds ZA200904031B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0623493.4A GB0623493D0 (en) 2006-11-24 2006-11-24 Chemical compounds

Publications (1)

Publication Number Publication Date
ZA200904031B true ZA200904031B (en) 2010-04-28

Family

ID=37636469

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200904031A ZA200904031B (en) 2006-11-24 2009-06-10 Chemical compounds

Country Status (26)

Country Link
US (1) US8658616B2 (de)
EP (2) EP2412717A1 (de)
JP (1) JP5271913B2 (de)
KR (1) KR20090114356A (de)
CN (1) CN101547932B (de)
AT (1) ATE512973T1 (de)
AU (1) AU2007323220B2 (de)
CA (1) CA2670328C (de)
CO (1) CO6230992A2 (de)
CY (1) CY1112254T1 (de)
DK (1) DK2097434T3 (de)
EC (1) ECSP099462A (de)
ES (1) ES2368012T3 (de)
GB (1) GB0623493D0 (de)
IL (1) IL198610A (de)
MX (1) MX2009005120A (de)
MY (1) MY145856A (de)
NO (1) NO20092399L (de)
NZ (2) NZ577152A (de)
PL (1) PL2097434T3 (de)
PT (1) PT2097434E (de)
RU (1) RU2464272C2 (de)
SG (1) SG171596A1 (de)
SI (1) SI2097434T1 (de)
WO (1) WO2008062206A2 (de)
ZA (1) ZA200904031B (de)

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Also Published As

Publication number Publication date
NZ593712A (en) 2012-09-28
US8658616B2 (en) 2014-02-25
EP2097434A2 (de) 2009-09-09
PL2097434T3 (pl) 2011-11-30
CO6230992A2 (es) 2010-12-20
GB0623493D0 (en) 2007-01-03
US20110124592A1 (en) 2011-05-26
DK2097434T3 (da) 2011-08-29
KR20090114356A (ko) 2009-11-03
NZ577152A (en) 2012-01-12
ES2368012T3 (es) 2011-11-11
AU2007323220A1 (en) 2008-05-29
PT2097434E (pt) 2011-09-07
IL198610A (en) 2013-11-28
CY1112254T1 (el) 2015-12-09
EP2412717A1 (de) 2012-02-01
ATE512973T1 (de) 2011-07-15
CN101547932A (zh) 2009-09-30
NO20092399L (no) 2009-06-24
ECSP099462A (es) 2009-08-28
JP5271913B2 (ja) 2013-08-21
SI2097434T1 (sl) 2011-10-28
JP2010510301A (ja) 2010-04-02
MY145856A (en) 2012-04-30
AU2007323220B2 (en) 2012-09-06
WO2008062206A2 (en) 2008-05-29
WO2008062206A3 (en) 2008-07-10
EP2097434B1 (de) 2011-06-15
CA2670328C (en) 2013-09-24
CN101547932B (zh) 2014-04-16
WO2008062206A8 (en) 2011-11-10
CA2670328A1 (en) 2008-05-29
MX2009005120A (es) 2009-09-23
SG171596A1 (en) 2011-06-29
RU2464272C2 (ru) 2012-10-20
RU2009123104A (ru) 2010-12-27
IL198610A0 (en) 2010-02-17

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