ZA200900836B - Process for the purification of FC-fusion proteins - Google Patents

Process for the purification of FC-fusion proteins

Info

Publication number
ZA200900836B
ZA200900836B ZA200900836A ZA200900836A ZA200900836B ZA 200900836 B ZA200900836 B ZA 200900836B ZA 200900836 A ZA200900836 A ZA 200900836A ZA 200900836 A ZA200900836 A ZA 200900836A ZA 200900836 B ZA200900836 B ZA 200900836B
Authority
ZA
South Africa
Prior art keywords
purification
fusion proteins
fusion
proteins
Prior art date
Application number
ZA200900836A
Other languages
English (en)
Inventor
Alex Eon-Duval
Alain Lamproye
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of ZA200900836B publication Critical patent/ZA200900836B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C07K1/28—Isoelectric focusing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
ZA200900836A 2006-08-28 2007-08-27 Process for the purification of FC-fusion proteins ZA200900836B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06119610 2006-08-28

Publications (1)

Publication Number Publication Date
ZA200900836B true ZA200900836B (en) 2010-05-26

Family

ID=37038258

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900836A ZA200900836B (en) 2006-08-28 2007-08-27 Process for the purification of FC-fusion proteins

Country Status (15)

Country Link
US (1) US20100267932A1 (xx)
EP (1) EP2061802A1 (xx)
KR (1) KR20090058532A (xx)
CN (1) CN101541825B (xx)
AR (1) AR062569A1 (xx)
AU (1) AU2007291282B2 (xx)
BR (1) BRPI0716139A2 (xx)
CA (1) CA2661872A1 (xx)
EA (1) EA017733B1 (xx)
IL (1) IL197221A (xx)
MX (1) MX2009002013A (xx)
NZ (1) NZ574623A (xx)
UA (1) UA99263C2 (xx)
WO (1) WO2008025747A1 (xx)
ZA (1) ZA200900836B (xx)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
AU2006330922B2 (en) 2005-12-20 2012-07-26 Bristol-Myers Squibb Company Compositions and methods for producing a composition
EP2089429B1 (en) * 2006-10-19 2014-11-26 Janssen Biotech, Inc. Process for preparing unaggregated antibody fc domains
WO2008085988A1 (en) * 2007-01-05 2008-07-17 Amgen Inc. Methods of purifying proteins
WO2011015926A1 (en) * 2009-08-03 2011-02-10 Avesthagen Limited A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
KR101844859B1 (ko) 2009-08-06 2018-05-18 제넨테크, 인크. 단백질 정제 시의 바이러스 제거의 개선방법
ES2817802T3 (es) * 2009-08-07 2021-04-08 Emd Millipore Corp Métodos para purificar una proteína objetivo de una o más impurezas en una muestra
WO2011028753A1 (en) * 2009-09-01 2011-03-10 Genentech, Inc. Enhanced protein purification through a modified protein a elution
US20120178910A1 (en) 2009-09-23 2012-07-12 Medarex, Inc. Cation exchange chromatography (methods)
EP2695889A1 (en) * 2009-12-29 2014-02-12 Dr. Reddy's Laboratories Limited Protein purification by ion exchange
US20130131318A1 (en) 2010-02-12 2013-05-23 Diderik Reinder Kremer Single unit antibody purification
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
EA201300524A1 (ru) * 2010-11-01 2013-08-30 ДСМ АйПи АССЕТС Б.В. Очистка антител ионообменной хроматографией в едином блоке
WO2012135415A1 (en) 2011-03-29 2012-10-04 Glaxosmithkline Llc Buffer system for protein purification
DK3415531T3 (da) * 2011-05-27 2023-09-18 Glaxo Group Ltd Bcma (cd269/tnfrsf17)-bindende proteiner
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
US20140128577A1 (en) * 2011-06-24 2014-05-08 Dr. Reddy's Laboratories Limited Purification of chimeric protein
JP2014523900A (ja) 2011-06-28 2014-09-18 インヒブルクス リミティド ライアビリティ カンパニー セルピン融合ポリペプチド及びその使用方法
CA2840951A1 (en) * 2011-07-08 2013-01-17 Merck Sharp & Dohme Corp. Methods for purifying fc-fusion protein
US9096648B2 (en) 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
PL2773438T5 (pl) * 2011-11-02 2022-01-17 F.Hoffmann-La Roche Ag Chromatografia przeciążenia i elucji
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US20200283472A1 (en) * 2016-03-29 2020-09-10 Navya Biologicals Pvt. Ltd A process for purification of fc-fusion proteins
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
WO2017194597A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3455241B1 (en) 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Method of cleaning and/or sanitizing a separation matrix
CN109790201A (zh) 2016-08-12 2019-05-21 百时美施贵宝公司 纯化蛋白质的方法
EP3580231A1 (en) * 2017-02-09 2019-12-18 Bracco Suisse SA Process for the purification of soluble psgl-1 protein variants
CN107151673A (zh) * 2017-03-10 2017-09-12 上海埃文生物科技有限公司 巴斯德毕赤酵母中人rank胞外段蛋白的表达纯化及其应用
US11964998B2 (en) 2017-08-30 2024-04-23 Fresenius Kabi Deutschland Gmbh Method for purifying anti-IL-6 receptor antibodies
EP3676281A1 (en) * 2017-08-30 2020-07-08 Ares Trading S.A. Method for purifying proteins
AU2019215363A1 (en) * 2018-01-31 2020-07-23 Regeneron Pharmaceuticals, Inc. System and method for characterizing size and charge variant drug product impurities
JP2021066730A (ja) * 2019-10-17 2021-04-30 Ｊｃｒファーマ株式会社 血清アルブミンと成長ホルモンの融合蛋白質の製造方法
MY190626A (en) * 2019-12-06 2022-04-27 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
AU2021231083A1 (en) * 2020-03-06 2022-09-29 Aleta Biotherapeutics, Inc. Compositions and methods for treatment of cancer
AU2021267276A1 (en) 2020-05-08 2022-12-15 Alpine Immune Sciences, Inc. April and BAFF inhibitory immunomodulatory proteins and methods of use thereof
CN112574321B (zh) * 2020-12-30 2023-10-20 上海赛金生物医药有限公司 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
WO1994006476A1 (en) * 1992-09-15 1994-03-31 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
EP0659767B2 (de) * 1993-12-27 2002-11-06 ZLB Bioplasma AG Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
US6406901B1 (en) * 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
WO1996041624A1 (en) * 1995-06-08 1996-12-27 Immunex Corporation TNF-α CONVERTING ENZYME
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
AU760048B2 (en) * 1998-05-06 2003-05-08 Genentech Inc. Protein purification by ion exchange chromatography
MXPA02011130A (es) * 2000-05-12 2003-03-10 Amgen Inc Metodos y composiciones de materia que se refieren a april/g70, bcma, blys/agp-3, y taci.
EA007275B1 (ru) * 2001-05-24 2006-08-25 Займодженетикс, Инк. Слитые белки taci-иммуноглобулина
EP1463942B2 (en) * 2001-12-21 2012-06-20 Immunex Corporation Methods for purifying protein
US20060234226A1 (en) * 2002-04-26 2006-10-19 Fahner Robert L Non-affinity purification of proteins
EP2261230B1 (en) * 2002-09-11 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Protein purification method
EP1614693A4 (en) * 2003-03-31 2006-07-19 Kirin Brewery PURIFICATION OF A HUMAN MONOCLONAL ANTIBODY AND A HUMAN POLYCLONAL ANTIBODY
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2418830T3 (es) * 2003-10-27 2013-08-16 Wyeth Llc Retirada de agregados de alto peso molecular usando cromatografía de hidroxiapatita
CN1234725C (zh) * 2004-04-07 2006-01-04 陈志南 一种高效快速纯化制备片段抗体的方法
RU2415865C2 (ru) * 2005-06-17 2011-04-10 Вайет СПОСОБЫ ОЧИСТКИ БЕЛКОВ, СОДЕРЖАЩИХ ОБЛАСТЬ Fc
AU2008206923A1 (en) * 2007-01-17 2008-07-24 Merck Serono S.A. Process for the purification of Fc-containing proteins

Also Published As

Publication number Publication date
UA99263C2 (ru) 2012-08-10
CN101541825A (zh) 2009-09-23
KR20090058532A (ko) 2009-06-09
EA017733B1 (ru) 2013-02-28
IL197221A0 (en) 2009-12-24
EA200970230A1 (ru) 2009-08-28
AR062569A1 (es) 2008-11-19
AU2007291282B2 (en) 2011-10-20
MX2009002013A (es) 2009-03-09
EP2061802A1 (en) 2009-05-27
BRPI0716139A2 (pt) 2013-09-17
AU2007291282A1 (en) 2008-03-06
US20100267932A1 (en) 2010-10-21
NZ574623A (en) 2011-12-22
WO2008025747A1 (en) 2008-03-06
CN101541825B (zh) 2013-08-14
IL197221A (en) 2013-06-27
CA2661872A1 (en) 2008-03-06

Similar Documents

Publication Publication Date Title
ZA200900836B (en) Process for the purification of FC-fusion proteins
HK1131400A1 (en) Process for the purification of fc-containing proteins
IL199753A0 (en) Process for the purification of fc-containing proteins
EP2054521A4 (en) METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
IL205107A0 (en) Method for purifying fc-fusion proteins
EP2226331A4 (en) METHOD OF PURIFYING PROTEINS
IL187642A0 (en) METHODS FOR PURIFYING PROTEINS HAVING Fc REGIONS
ZA200905167B (en) Process for the purification of water
HUE042402T2 (hu) Eljárás polipeptid töményítésére
EP1922345A4 (en) PROCESS FOR THE PREPARATION OF COPOLYMER-1
IL204949A0 (en) Method for purifying an fc- containing protein
EP1869230A4 (en) PROCESS FOR PURIFYING PROTEINS
ZA200607439B (en) Process for gas purification
GB0503942D0 (en) Purification process
GB0604236D0 (en) Adsorbents for protein purification
ZA200900837B (en) Process for the purification of FC-containing proteins
GB0624227D0 (en) Protein purification
PL1973563T3 (pl) Sposób oczyszczania alfa-1-antytrypsyny
EP1899375A4 (en) NEW METHOD FOR THE PURIFICATION OF LACTOFERRIN
ZA201200420B (en) Method for the purification of protein complexes
GB0523257D0 (en) Purification process
ZA200708802B (en) An improved process for the purification of perindopril
HK1137378A1 (en) Process for the purification of combustion fumes
PL2079758T3 (pl) Sposób oczyszczania DnaK
PL380473A1 (pl) Sposób wytwarzania modyfikowanego kaolinu