ZA200805574B - Indol-3-yl-carbonyl-spiro-piperidine derivatives - Google Patents

Indol-3-yl-carbonyl-spiro-piperidine derivatives

Info

Publication number
ZA200805574B
ZA200805574B ZA200805574A ZA200805574A ZA200805574B ZA 200805574 B ZA200805574 B ZA 200805574B ZA 200805574 A ZA200805574 A ZA 200805574A ZA 200805574 A ZA200805574 A ZA 200805574A ZA 200805574 B ZA200805574 B ZA 200805574B
Authority
ZA
South Africa
Prior art keywords
indol
spiro
carbonyl
piperidine derivatives
piperidine
Prior art date
Application number
ZA200805574A
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200805574B publication Critical patent/ZA200805574B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200805574A 2006-01-05 2008-06-25 Indol-3-yl-carbonyl-spiro-piperidine derivatives ZA200805574B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06100118 2006-01-05

Publications (1)

Publication Number Publication Date
ZA200805574B true ZA200805574B (en) 2009-12-30

Family

ID=37989141

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200805574A ZA200805574B (en) 2006-01-05 2008-06-25 Indol-3-yl-carbonyl-spiro-piperidine derivatives

Country Status (15)

Country Link
US (1) US7351706B2 (fr)
EP (1) EP1973913A1 (fr)
JP (1) JP2009522318A (fr)
KR (1) KR101121349B1 (fr)
CN (1) CN101356174B (fr)
AR (1) AR059136A1 (fr)
AU (1) AU2006334423B2 (fr)
BR (1) BRPI0620951A2 (fr)
CA (1) CA2634120A1 (fr)
IL (1) IL192401A0 (fr)
NO (1) NO20082733L (fr)
RU (1) RU2420529C2 (fr)
TW (1) TW200734343A (fr)
WO (1) WO2007077122A1 (fr)
ZA (1) ZA200805574B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
MX2007002033A (es) 2004-08-19 2007-04-26 Vertex Pharma Moduladores de receptores muscarinicos.
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
WO2007039438A1 (fr) * 2005-09-28 2007-04-12 F. Hoffmann-La Roche Ag Composés indol-3-ylcarbonylazaspiro en tant qu'antagonistes du récepteur de la vasopressine
JP2009521483A (ja) * 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
RU2008137593A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
EP2051712A2 (fr) * 2006-08-15 2009-04-29 Vertex Pharmceuticals Incorporated Modulateurs de récepteurs muscariniques
JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
DE602007006989D1 (en) * 2006-12-07 2010-07-15 Hoffmann La Roche Spiropiperidinderivate
EP2207549A1 (fr) * 2007-10-03 2010-07-21 Vertex Pharmceuticals Incorporated Modulateurs des récepteurs muscariniques
US8846684B2 (en) 2011-03-31 2014-09-30 The Regents Of The University Of Michigan Arbovirus inhibitors and uses thereof
CA2866218C (fr) 2012-03-16 2020-06-09 Vitae Pharmaceuticals, Inc. Modulateurs du recepteur x du foie
DK2825542T3 (en) 2012-03-16 2017-01-09 Vitae Pharmaceuticals Inc LIVER-X-receptor modulators
BR112016013058B1 (pt) 2013-12-19 2021-02-23 F. Hoffmann-La Roche Ag Espiro-oxazolonas, seus usos, seus intermediários e composiçãofarmacêutica
ES2951874T3 (es) * 2017-09-05 2023-10-25 Neumora Therapeutics Inc Antagonistas del receptor de vasopresina y productos y métodos relacionados con los mismos
WO2020048828A1 (fr) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft Composés du 5-hétéroaryl-3,9-diazaspiro[5.5]undécane
WO2020048826A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de la 1-oxa-3,9-diazaspiro[5.5]undécan-2-one substituée en position 5
WO2020048831A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés 5-aryl-3,9-diazaspiro[5.5]undécan-2-one
WO2020048829A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de 3,9-diazaspiro[5.5]undécane
WO2020048830A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés 5-aryl-3,9-diazaspiro[5.5]undécan-2-one

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349549A (en) * 1981-05-18 1982-09-14 Syntex (U.S.A.) Inc. Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
CA2298813A1 (fr) 1997-08-28 1999-03-04 Merck & Co., Inc. Modulateurs de pyrrolidine et de piperidine de l'activite du recepteur de chemokine
US6013652A (en) 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
WO2001022919A2 (fr) 1999-09-30 2001-04-05 Merck & Co., Inc. Derives de spiro[azacycloalkyle et cycloalkyle bicycliques] et utilisations de ceux-ci
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
SI1549638T1 (sl) 2002-10-03 2008-02-29 Hoffmann La Roche Indol-3-karboksiamidi kot aktivatorji glukokinaze(gk)
RU2414466C2 (ru) 2005-07-14 2011-03-20 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ ИНДОЛ-3-КАРБОНИЛ-СПИРО-ПИПЕРИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ V1a

Also Published As

Publication number Publication date
RU2008125813A (ru) 2010-02-10
EP1973913A1 (fr) 2008-10-01
US20070155761A1 (en) 2007-07-05
TW200734343A (en) 2007-09-16
KR20080073364A (ko) 2008-08-08
IL192401A0 (en) 2008-12-29
US7351706B2 (en) 2008-04-01
CN101356174A (zh) 2009-01-28
AU2006334423A1 (en) 2007-07-12
WO2007077122A1 (fr) 2007-07-12
CN101356174B (zh) 2011-11-23
RU2420529C2 (ru) 2011-06-10
AR059136A1 (es) 2008-03-12
BRPI0620951A2 (pt) 2011-11-29
JP2009522318A (ja) 2009-06-11
CA2634120A1 (fr) 2007-07-12
AU2006334423B2 (en) 2011-09-22
NO20082733L (no) 2008-10-02
KR101121349B1 (ko) 2012-03-09

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