ZA200803761B - Process for the preparation of a leukotriene antagonist and intermediates thereof - Google Patents
Process for the preparation of a leukotriene antagonist and intermediates thereofInfo
- Publication number
- ZA200803761B ZA200803761B ZA200803761A ZA200803761A ZA200803761B ZA 200803761 B ZA200803761 B ZA 200803761B ZA 200803761 A ZA200803761 A ZA 200803761A ZA 200803761 A ZA200803761 A ZA 200803761A ZA 200803761 B ZA200803761 B ZA 200803761B
- Authority
- ZA
- South Africa
- Prior art keywords
- intermediates
- preparation
- leukotriene antagonist
- leukotriene
- antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05110348A EP1783117A1 (en) | 2005-11-04 | 2005-11-04 | Process for the preparation of a leukotriene antagonist and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200803761B true ZA200803761B (en) | 2009-09-30 |
Family
ID=36169064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200803761A ZA200803761B (en) | 2005-11-04 | 2006-11-03 | Process for the preparation of a leukotriene antagonist and intermediates thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US20080306270A1 (xx) |
EP (2) | EP1783117A1 (xx) |
JP (1) | JP2009514927A (xx) |
KR (1) | KR20080064968A (xx) |
CN (1) | CN101321732B (xx) |
AU (1) | AU2006310536A1 (xx) |
CA (1) | CA2627098A1 (xx) |
NO (1) | NO20082474L (xx) |
RU (1) | RU2402532C2 (xx) |
WO (1) | WO2007051828A2 (xx) |
ZA (1) | ZA200803761B (xx) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100899585B1 (ko) | 2005-07-05 | 2009-05-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트의 정제 |
KR101072896B1 (ko) | 2007-10-09 | 2011-10-17 | 한미홀딩스 주식회사 | 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법 |
EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
CN103539714A (zh) * | 2012-07-16 | 2014-01-29 | 上海朴颐化学科技有限公司 | 1-巯甲基环丙基乙酸及其中间体的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
-
2005
- 2005-11-04 EP EP05110348A patent/EP1783117A1/en not_active Withdrawn
-
2006
- 2006-11-03 RU RU2008122367/04A patent/RU2402532C2/ru not_active IP Right Cessation
- 2006-11-03 CN CN2006800453024A patent/CN101321732B/zh not_active Expired - Fee Related
- 2006-11-03 KR KR1020087010722A patent/KR20080064968A/ko not_active Application Discontinuation
- 2006-11-03 CA CA002627098A patent/CA2627098A1/en not_active Abandoned
- 2006-11-03 ZA ZA200803761A patent/ZA200803761B/xx unknown
- 2006-11-03 AU AU2006310536A patent/AU2006310536A1/en not_active Abandoned
- 2006-11-03 US US12/092,554 patent/US20080306270A1/en not_active Abandoned
- 2006-11-03 EP EP06819233A patent/EP1948611B1/en active Active
- 2006-11-03 JP JP2008539405A patent/JP2009514927A/ja active Pending
- 2006-11-03 WO PCT/EP2006/068052 patent/WO2007051828A2/en active Application Filing
-
2008
- 2008-06-02 NO NO20082474A patent/NO20082474L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20082474L (no) | 2008-06-02 |
US20080306270A1 (en) | 2008-12-11 |
WO2007051828A2 (en) | 2007-05-10 |
JP2009514927A (ja) | 2009-04-09 |
CN101321732A (zh) | 2008-12-10 |
AU2006310536A1 (en) | 2007-05-10 |
EP1948611B1 (en) | 2012-05-23 |
RU2008122367A (ru) | 2009-12-10 |
RU2402532C2 (ru) | 2010-10-27 |
EP1948611A2 (en) | 2008-07-30 |
CN101321732B (zh) | 2011-04-13 |
CA2627098A1 (en) | 2007-05-10 |
KR20080064968A (ko) | 2008-07-10 |
WO2007051828A3 (en) | 2007-08-23 |
EP1783117A1 (en) | 2007-05-09 |
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