ZA200802767B - Process for production of delta-9-tetrahydrocannabinol - Google Patents

Process for production of delta-9-tetrahydrocannabinol

Info

Publication number
ZA200802767B
ZA200802767B ZA200802767A ZA200802767A ZA200802767B ZA 200802767 B ZA200802767 B ZA 200802767B ZA 200802767 A ZA200802767 A ZA 200802767A ZA 200802767 A ZA200802767 A ZA 200802767A ZA 200802767 B ZA200802767 B ZA 200802767B
Authority
ZA
South Africa
Prior art keywords
tetrahydrocannabinol
delta
production
Prior art date
Application number
ZA200802767A
Other languages
English (en)
Inventor
David C Burdick
Steven J Collier
Jos Frederic
Biolatto Betina
Bernhard J Paul
Meckler Harold
Mark A Helle
Alicia J Habershaw
Original Assignee
Amr Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc filed Critical Amr Technology Inc
Publication of ZA200802767B publication Critical patent/ZA200802767B/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/16Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
ZA200802767A 2005-09-29 2006-09-28 Process for production of delta-9-tetrahydrocannabinol ZA200802767B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72203105P 2005-09-29 2005-09-29

Publications (1)

Publication Number Publication Date
ZA200802767B true ZA200802767B (en) 2009-09-30

Family

ID=37906689

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802767A ZA200802767B (en) 2005-09-29 2006-09-28 Process for production of delta-9-tetrahydrocannabinol

Country Status (11)

Country Link
US (3) US7674922B2 (zh)
EP (3) EP2578577A1 (zh)
JP (1) JP2009510078A (zh)
KR (1) KR20080063800A (zh)
CN (2) CN101316832A (zh)
AU (1) AU2006297300B2 (zh)
CA (1) CA2623723A1 (zh)
IL (1) IL190388A0 (zh)
NZ (3) NZ594077A (zh)
WO (1) WO2007041167A2 (zh)
ZA (1) ZA200802767B (zh)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980940B2 (en) 2006-11-10 2015-03-17 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
US8039509B2 (en) 2006-11-10 2011-10-18 Johnson Matthey Public Limited Company Composition comprising (−)-Δ9-trans-tetrahydrocannabinol
GB0702895D0 (en) * 2007-02-14 2007-03-28 Resolution Chemicals Ltd Delta 9 tetrahydrocannabinol derivatives
GB0703284D0 (en) 2007-02-20 2007-03-28 Resolution Chemicals Ltd Delta 9 - tetrahydrocannabinol processing
ES2716407T3 (es) 2007-11-30 2019-06-12 Zynerba Pharmaceuticals Inc Profármacos de tetrahidrocannabinol, composiciones que comprenden profármacos de tetrahidrocannabinol y métodos para uso de los mismos
CA2751741C (en) * 2008-02-06 2018-07-10 Mallinckrodt Inc. Process for the preparation of (-) -delta 9-tetrahydrocannabinol
GB0807915D0 (en) * 2008-05-01 2008-06-04 Resolution Chemicals Ltd Production of delta 9 tetrahydrocannabinol
US8445034B1 (en) 2010-11-02 2013-05-21 Albert L Coles, Jr. Systems and methods for producing organic cannabis tincture
ES2547354T3 (es) * 2013-09-03 2015-10-05 Symrise Ag Mezclas de compuestos cannabinoides, su preparación y uso
US9380813B2 (en) 2014-02-11 2016-07-05 Timothy McCullough Drug delivery system and method
US9220294B2 (en) 2014-02-11 2015-12-29 Timothy McCullough Methods and devices using cannabis vapors
US10821240B2 (en) 2014-02-11 2020-11-03 Vapor Cartridge Technology Llc Methods and drug delivery devices using cannabis
US10045540B2 (en) 2014-04-01 2018-08-14 Fayetteville State University Pest control composition
IL302782A (en) * 2014-05-29 2023-07-01 Radius Pharmaceuticals Inc Stable cannabinoid formulations
GB2530001B (en) 2014-06-17 2019-01-16 Gw Pharma Ltd Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy
GB2531281A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabidiol in the treatment of intractable epilepsy
CA2976004C (en) * 2015-02-05 2020-06-02 Colorado Can Llc Purified cbd and cbda, and methods, compositions and products employing cbd or cbda
EP3061450A1 (de) 2015-02-26 2016-08-31 Symrise AG Mischungen cannabinoider Verbindungen, deren Herstellung und Verwendung
US20170008869A1 (en) 2015-07-10 2017-01-12 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
ES2907623T3 (es) 2016-05-13 2022-04-25 Symrise Ag Método para purificar compuestos cannabinoides mediante cromatografía de lecho móvil simulado
US10399920B2 (en) 2016-06-01 2019-09-03 S&B Pharma, Inc. Crystalline form of cannabidiol
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
CN106632214B (zh) * 2016-12-28 2019-01-25 西北大学 一种大麻酚类化合物的合成方法
US10702495B2 (en) 2017-02-20 2020-07-07 Nexien Biopharma, Inc. Method and compositions for treating dystrophies and myotonia
EP3509638B1 (en) * 2017-06-20 2022-01-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Cannabidiolic acid esters compositions and uses thereof
US10640482B2 (en) 2017-07-21 2020-05-05 University Of South Florida Synthesis of cannabinoids
US10272360B2 (en) 2017-08-05 2019-04-30 Priya Naturals, Inc. Phytochemical extraction system and methods to extract phytochemicals from plants including plants of the family Cannabaceae sensu stricto
CN111183127B (zh) 2017-08-07 2023-02-21 南迪亚公司 大麻二酚的共晶
CA3072961A1 (en) * 2017-08-16 2019-02-21 The University Of Sydney Synthesis of phytocannabinoids including a decarboxylation step
WO2019046806A1 (en) * 2017-09-01 2019-03-07 Botaniteck Llc SYNTHETIC CANNABIDIOL COMPOSITIONS AND METHODS OF MAKING THE SAME
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
US11192870B2 (en) 2018-03-07 2021-12-07 Socati Technologies—Oregon, Llc Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
US11851415B2 (en) 2018-03-07 2023-12-26 Cleen Technology Inc. Continuous isolation of cannabidiol and cannabinoids and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
EP3539637A1 (en) * 2018-03-13 2019-09-18 CLS Labs, Inc. Cannabidiol extraction and conversion process
CA3073093A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
WO2020031179A1 (en) 2018-08-06 2020-02-13 Beetlebung Pharma Ltd. Methods for synthesis of cannabinoid compounds
US10822320B2 (en) * 2018-08-10 2020-11-03 Natural Extraction Systems, LLC Methods to purify cannabinoids
US20220218651A1 (en) 2018-09-05 2022-07-14 Purisys Llc Cannabidiol compositions having modified cannabinoid profiles
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
WO2020089424A1 (en) 2018-10-31 2020-05-07 Enantia, S.L. Solid compositions of cocrystals of cannabinoids
CN109734554B (zh) * 2019-02-25 2021-11-23 江苏暨明医药科技有限公司 一种反式-薄荷基-2,8-二烯-1-醇的合成工艺
CA3135650A1 (en) * 2019-04-05 2020-10-08 Rapid Dose Therapeutics Corp. Apparatus for and method of converting cbd and/or cbd derivatives to at least one other type of cannabinoid and/or cannabinoid derivative such as thc
WO2020219687A1 (en) 2019-04-23 2020-10-29 Joint Venture Holdings, LLC Cannabis processing systems and methods
US10569189B1 (en) * 2019-05-17 2020-02-25 NextLeaf Solutions Ltd. Method for acetylation of cannabinoids
CN111943813B (zh) * 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
AU2020280231A1 (en) * 2019-05-23 2021-12-02 Kare Chemical Technologies Inc. Catalytic cannabinoid processes and precursors
EP3983395A4 (en) * 2019-06-11 2023-10-18 Canopy Growth Corporation IMPROVED PROCESSES FOR CONVERTING CANNABIDIOL TO DELTA 8-TETRAHYDROCANNABINOL
EP3750528A1 (en) 2019-06-11 2020-12-16 Nexien Biopharma, Inc. Compositions for treating dystrophies and myotonia
EP3983396A4 (en) * 2019-06-11 2023-05-10 Canopy Growth Corporation IMPROVED METHODS FOR CONVERTING CANNABIDIOL TO DELTA9-TETRAHYDROCANNABINOL UNDER PURE OR APROTIC REACTION CONDITIONS
WO2020248060A1 (en) * 2019-06-11 2020-12-17 Canopy Growth Corporation Improved methods for converting cannabidiol into delta9-tetrahydrocannabinol under protic reaction conditions
CA3148236A1 (en) 2019-07-22 2021-01-28 Canopy Growth Corporation Continuous crystallization of cannabinoids in a stirred-tank reactor
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
US10954209B1 (en) * 2019-09-15 2021-03-23 NextLeaf Solutions Ltd. Acetylation of cannabinoids using sulfuric acid catalyst
CA3154135A1 (en) 2019-09-16 2021-03-25 Vapor Cartridge Technology Llc Drug delivery system with stackable substrates
US11542243B1 (en) * 2019-09-26 2023-01-03 FusionFarms, LLC Method of converting delta9-THC to delta10-THC and the purification of the delta10-THC by crystallization
CA3163788A1 (en) 2019-12-06 2021-06-10 JLABS Beauty LLC Topical compositions containing rose oil and cannabidiol and methods of making and using the same
EP4088723A4 (en) * 2020-01-08 2024-02-21 Chengdu Baiyu Pharmaceutical Co Ltd CANNABIDIOL DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAL USE THEREOF
CN113087743B (zh) * 2020-01-08 2023-04-28 成都百裕制药股份有限公司 四氢大麻酚衍生物及其制备方法和在医药上的应用
US11767306B2 (en) * 2020-01-17 2023-09-26 Cannacraft, Inc Methods for converting CBD to tetrahydrocannabinols
US10981849B1 (en) * 2020-02-20 2021-04-20 Sci Pharmtech Inc. Method for preparing cannabinoids
PL3868736T3 (pl) 2020-02-21 2023-03-13 Sci Pharmtech Inc Wolny od rozpuszczalnika sposób przygotowania kannabinoidów
GB202002754D0 (en) 2020-02-27 2020-04-15 Gw Res Ltd Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
AU2021235467A1 (en) 2020-03-12 2021-10-07 Council Of Scientific And Industrial Research Process for the synthesis of cannabidiol and intermediates thereof
US11786838B2 (en) 2020-03-23 2023-10-17 Cannacraft, Inc. Methods for removing pesticides from Cannabis products
BR112022019616A2 (pt) 2020-03-31 2022-12-06 Phytotherapeutix Ltd Compostos terpenofenólicos e seu uso
AU2021276680A1 (en) 2020-05-22 2023-01-19 Ilera Derm LLC Compositions for treating acne and dermatological conditions
CN113896616A (zh) * 2020-07-06 2022-01-07 复旦大学 一种大麻二酚的制备方法
CN112094257B (zh) * 2020-08-19 2023-08-22 公安部禁毒情报技术中心 一种△-9四氢大麻酚的制备方法
CN114644547A (zh) * 2020-12-21 2022-06-21 云南汉盟制药有限公司 一种大麻二酚和/或次大麻二酚的制备方法
CN115504864A (zh) * 2021-06-07 2022-12-23 南通新世元生物科技有限公司 从工业大麻中获取高纯度大麻二酚的方法
CN113979836B (zh) * 2021-10-13 2023-05-30 上海应用技术大学 一种4-异丙烯基-1-甲基-2-环己烯-1-醇的制备方法
WO2024028516A1 (en) 2022-08-05 2024-02-08 Salud & Semillas, S.L. CANNABINOID SYNTHESIS STARTING OUT FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FeCl3 * 6H2O AS CATALYST
CN115583933B (zh) * 2022-10-31 2024-02-06 暨明医药科技(苏州)有限公司 一种高纯度四氢大麻素同系物的制备方法

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509387A (en) * 1950-05-30 Dibenzopyran marihuana-like
US2304669A (en) * 1940-08-16 1942-12-08 Adams Roger Isolation of cannabidiol
GB558418A (en) 1940-08-16 1944-01-05 Roger Adams Process for securing pharmacologically useful products from cannabidiol
US2419935A (en) * 1941-07-09 1947-05-06 Adams Roger Marihuana active compounds
US2419934A (en) * 1941-07-09 1947-05-06 Adams Roger Optically active tetrahydrodibenzopyrans having marihuana activity and process for making same
US2419936A (en) * 1942-04-29 1947-05-06 Adams Roger Preparation of compounds with marihuana activity
US3636058A (en) * 1966-03-25 1972-01-18 Hoffmann La Roche 7 10 - dihydro - 3 - alkyl - 6h - dibenzo(b d) pyran-6 9(8h)-diones and 5-hydroxy-7-alkyl-4-chromanones
US3507885A (en) * 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
CH473075A (de) * 1966-11-04 1969-05-31 Theodor Dr Petrzilka Verfahren zur Herstellung von in 2-Stellung substituierten Resorcinderivaten
US3920705A (en) * 1967-05-19 1975-11-18 Theodore Petrzilka 6a,10a-trans-6a,10,10a-tetrahydrodibenzo(b,d)-pyrans
US3833616A (en) * 1968-09-16 1974-09-03 T Petrzilka 6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo(b,d)-pyrans
US3919322A (en) * 1969-01-22 1975-11-11 Hoffmann La Roche 3-Substituted -5-alkyl-2-cyclohexen-1-ones
US3734930A (en) * 1971-09-22 1973-05-22 R Razdan Direct synthesis of ({31 )-trans-{66 {11 tetrahydrocannabinol from olivetol and ({30 )-trans-{66 {11 -carene oxide
US4278603A (en) * 1973-11-05 1981-07-14 Eli Lilly And Company Novel polymorphic crystalline form of dibenzopyranone
US4116979A (en) * 1975-06-23 1978-09-26 Sheehan Institute For Research, Inc. Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
US4025516A (en) * 1975-06-23 1977-05-24 The John C. Sheehan Institute For Research, Inc. Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
IL48824A (en) * 1976-01-12 1980-05-30 Yissum Res Dev Co Pharmaceutical compositions containing (3s,js) tetrahydrocanabinol derivatives and some novel compounds of this type
CA1088083A (en) * 1976-07-06 1980-10-21 Charles W. Ryan Process for preparing cis-hexahydrodibenzopyranones
US4054582A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones
CA1096390A (en) * 1976-07-06 1981-02-24 Edward R. Lavagnino PROCESS FOR PREPARING DL-CIS-1-HYDROXY-3-SUBSTITUTED- 6,6-DIMETHYL-6,6.alpha.,7,8,10,10.alpha.-HEXAHYDRO-9H- DIBENZO(B,D,)PYRAN-9-ONES
US4075230A (en) * 1976-11-10 1978-02-21 Eli Lilly And Company Preparation of optically active trans-hexahydrodibenzopyranones
US4102902A (en) 1976-11-10 1978-07-25 Eli Lilly And Company Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
US4171315A (en) * 1978-03-31 1979-10-16 Eli Lilly And Company Preparation of cis-hexahydrodibenzopyranones
US4202902A (en) * 1979-03-05 1980-05-13 Shell Oil Company Lipogenesis control by cyclopropane-carboxylic acids, esters and amides
CH646933A5 (fr) * 1981-05-04 1984-12-28 Firmenich & Cie Procede pour la preparation de (+)-p-mentha-2,8-diene-1-ol.
US4381399A (en) * 1981-12-21 1983-04-26 Aerojet-General Corporation Purification of tetrahydrodibenzo[b,d]pyrans from crude synthetic mixtures
IL80411A (en) * 1986-10-24 1991-08-16 Raphael Mechoulam Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them
US4933363A (en) * 1988-08-16 1990-06-12 Elsohly Mahmoud A Method for effecting systemic delivery of delta-9-tetrahydrocannabinol
IL92238A (en) 1989-11-07 1995-07-31 Yissum Res Dev Co ADMN blocking product containing tetrahydrocannabinol history, several new tetrahydrocannabinol histories and process for their preparation
US5521215A (en) 1989-11-07 1996-05-28 Ramot University Authority For Applied Research And Industrial Development Ltd. NMDA-blocking pharmaceuticals
DE4100441A1 (de) * 1991-01-09 1992-07-16 Mack Chem Pharm Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol
US5538993A (en) * 1991-09-12 1996-07-23 Yissum Research Development Company Certain tetrahydrocannabinol-7-oic acid derivatives
US5635530A (en) * 1991-09-12 1997-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them
US5292899A (en) * 1991-11-27 1994-03-08 Synthetic Technology Corporation Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
IL102082A (en) * 1992-06-02 1997-07-13 Yissum Res Dev Co Antiemetic composition containing a cannabinol derivative
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
US5342971A (en) * 1992-12-29 1994-08-30 The Australian National University Process for the preparation of dibenzo[b,d]pyrans
US5389375A (en) * 1993-05-21 1995-02-14 University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -thc
US5440052A (en) * 1993-08-06 1995-08-08 University Of Connecticut Compositions useful as a cannabinoid receptor probe
JPH07196565A (ja) * 1993-12-28 1995-08-01 Idemitsu Petrochem Co Ltd 4−アルキル−2−フルオロシクロヘキサノールとその製造方法及びその光学分割方法
IL115245A (en) * 1995-09-11 2002-12-01 Yissum Res Dev Co Tumor necrosis factor inhibiting pharmaceuticals
US6328992B1 (en) 1997-03-03 2001-12-11 Lawrence L. Brooke Cannabinoid patch and method for cannabis transdermal delivery
US6148261A (en) * 1997-06-20 2000-11-14 American Calcar, Inc. Personal communication system to send and receive voice data positioning information
US6162829A (en) * 1997-10-17 2000-12-19 Atlantic Pharmaceuticals, Inc. (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics
DE69936640D1 (de) * 1998-04-21 2007-09-06 Us Health Cannabinoiden als antioxidantien und neuroschützende mittel
US6455650B1 (en) * 1998-10-05 2002-09-24 The B.F. Goodrich Company Catalyst and methods for polymerizing cycloolefins
US6730519B2 (en) * 1998-10-26 2004-05-04 The University Of Mississippi Method of preparing delta-9-tetrahydrocannabinol
US6008383A (en) * 1998-10-26 1999-12-28 University Of Mississippi Method of preparing delta-9-tetrahydrocannabinol esters
JP2002539246A (ja) * 1999-03-22 2002-11-19 イミュジェン ファーマシューティカルズ インコーポレイティッド 免疫疾患の治療
US6566560B2 (en) * 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US6949582B1 (en) * 1999-05-27 2005-09-27 Wallace Walter H Method of relieving analgesia and reducing inflamation using a cannabinoid delivery topical liniment
FR2795731B1 (fr) * 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
US6563009B1 (en) * 1999-07-12 2003-05-13 Virginia Commonwealth University Vasodilator cannabinoid analogs
AU779324B2 (en) 1999-08-20 2005-01-20 Abbott Laboratories Composition for inhalation comprising delta-9-tetrahydrocannabinol in a semiaqueous solvent
WO2001072749A1 (fr) * 2000-03-27 2001-10-04 Takeda Chemical Industries, Ltd. Derives de pyrazole condense, procede de production et utilisation
US6448288B1 (en) * 2000-05-17 2002-09-10 University Of Massachusetts Cannabinoid drugs
US6974835B2 (en) * 2000-05-17 2005-12-13 Indevus Pharmaceuticals, Inc. Methods for decreasing cell proliferation based on (3r,4r)-Δ8-tetrahydrocannabinol-11-oic acids
IL136839A (en) 2000-06-16 2006-12-10 Yissum Res Dev Co Pharmaceutical compositions comprising cannabidiol derivatives, and processes for the preparation of same
US7235584B2 (en) * 2000-06-22 2007-06-26 Pharmos Corporation Non-psychotropic cannabinoids
KR20030008153A (ko) * 2000-06-22 2003-01-24 파모스 코포레이션 신규 비-향정신성 카나비노이드
DE10051427C1 (de) 2000-10-17 2002-06-13 Adam Mueller Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte
US20020111377A1 (en) * 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
DE10106024B4 (de) 2001-02-09 2004-10-14 Thc Pharm Gmbh Verfahren zur Herstellung von Dronabinol
WO2002070506A2 (en) * 2001-03-07 2002-09-12 Websar Innovations Inc. Conversion of cbd to δ8-thc and δ9-thc
GB2377218A (en) 2001-05-04 2003-01-08 Gw Pharmaceuticals Ltd Process and apparatus for extraction of active substances and enriched extracts from natural products
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
GB0112748D0 (en) 2001-05-25 2001-07-18 Johnson Matthey Plc Uncatalysed addition reactions
US20030017216A1 (en) * 2001-07-23 2003-01-23 Schmidt Robert Gustav Isolation of herbal and cannabinoid medicinal extracts
GB2381450B (en) 2001-10-31 2006-05-31 Gw Pharma Ltd Compositions for administration of natural or synthetic cannabinoids by vaporisation
ES2305437T3 (es) * 2002-02-01 2008-11-01 Resolution Chemicals Limited Produccion de delta-9 tetrahidrocannabinol.
AU2002326312A1 (en) 2002-04-25 2003-11-10 Virginia Commonwealth University Cannabinoids
US6946150B2 (en) * 2002-08-14 2005-09-20 Gw Pharma Limited Pharmaceutical formulation
US20040043946A1 (en) * 2002-09-03 2004-03-04 Popp Karl F. Topical formulations for treatment of skin disorders
GB0222077D0 (en) 2002-09-23 2002-10-30 Gw Pharma Ltd Methods of preparing cannabinoids from plant material
GB2393182B (en) 2002-09-23 2007-03-14 Gw Pharma Ltd Method of preparing cannabidiol from plant material
AU2003287585B2 (en) * 2002-11-12 2009-05-07 Mallinckrodt Inc. Cannabinoid crystalline derivatives and process of cannabinoid purification
IL153277A0 (en) * 2002-12-04 2003-07-06 Pharmos Corp High enantiomeric purity dexanabinol for pharmaceutical compositions
US20040248970A1 (en) * 2003-04-10 2004-12-09 Webster G.R. Barrie CBD-delta8-THC composition
WO2004092101A2 (en) 2003-04-10 2004-10-28 Mallinckrodt Inc. Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol
ATE496901T1 (de) 2003-05-20 2011-02-15 Univ Tennessee Res Foundation Cannabinoidderivate, verfahren zu deren herstellung und deren verwendung
US20070287843A1 (en) 2004-04-07 2007-12-13 Cabaj John E Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol
GB2414933B (en) 2004-06-08 2009-07-15 Gw Pharma Ltd Cannabinoid compositions for the treatment of disease and/or symptoms in arthritis
US7923558B2 (en) 2004-07-19 2011-04-12 Cilag Ltd. Method for obtaining pure tetrahydrocannabinol
US7323576B2 (en) * 2004-10-01 2008-01-29 Alphora Research Inc. Synthetic route to dronabinol
TWI369203B (en) 2004-11-22 2012-08-01 Euro Celtique Sa Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol
KR20070118069A (ko) 2004-12-09 2007-12-13 인시스 테라퓨틱스, 인코포레이티드 실온에서 안정한 드로나비놀 제형

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WO2007041167A3 (en) 2007-11-22
WO2007041167A2 (en) 2007-04-12
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EP2578577A1 (en) 2013-04-10
AU2006297300B2 (en) 2012-05-10
NZ567029A (en) 2011-09-30
US7674922B2 (en) 2010-03-09
US20110263878A1 (en) 2011-10-27
US20100069651A1 (en) 2010-03-18
IL190388A0 (en) 2008-11-03
EP1928853A2 (en) 2008-06-11
CN102766128A (zh) 2012-11-07
US8106244B2 (en) 2012-01-31
US20070093665A1 (en) 2007-04-26
NZ594077A (en) 2013-02-22
CN101316832A (zh) 2008-12-03
NZ601567A (en) 2013-03-28
EP1928853A4 (en) 2011-02-16
AU2006297300A1 (en) 2007-04-12
KR20080063800A (ko) 2008-07-07
JP2009510078A (ja) 2009-03-12

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