ZA200710688B - Antiarrhythmic precursor compounds, methods of synthesis and methods of use - Google Patents

Antiarrhythmic precursor compounds, methods of synthesis and methods of use

Info

Publication number
ZA200710688B
ZA200710688B ZA200710688A ZA200710688A ZA200710688B ZA 200710688 B ZA200710688 B ZA 200710688B ZA 200710688 A ZA200710688 A ZA 200710688A ZA 200710688 A ZA200710688 A ZA 200710688A ZA 200710688 B ZA200710688 B ZA 200710688B
Authority
ZA
South Africa
Prior art keywords
methods
antiarrhythmic
synthesis
compounds
precursor compounds
Prior art date
Application number
ZA200710688A
Other languages
English (en)
Inventor
Druzgala Pascal
Jien-Heh J Tien
Cooper Art
Becker Cyrus
Original Assignee
Aryx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics Inc filed Critical Aryx Therapeutics Inc
Publication of ZA200710688B publication Critical patent/ZA200710688B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
ZA200710688A 2005-07-15 2007-12-07 Antiarrhythmic precursor compounds, methods of synthesis and methods of use ZA200710688B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69978005P 2005-07-15 2005-07-15

Publications (1)

Publication Number Publication Date
ZA200710688B true ZA200710688B (en) 2009-09-30

Family

ID=37492022

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710688A ZA200710688B (en) 2005-07-15 2007-12-07 Antiarrhythmic precursor compounds, methods of synthesis and methods of use

Country Status (20)

Country Link
US (1) US7498449B2 (fr)
EP (2) EP1904502B1 (fr)
JP (1) JP2009501723A (fr)
KR (1) KR20080040645A (fr)
CN (1) CN101248079A (fr)
AT (1) ATE446300T1 (fr)
AU (1) AU2006270086B2 (fr)
BR (1) BRPI0613047A8 (fr)
CA (1) CA2612599C (fr)
CY (1) CY1109613T1 (fr)
DE (1) DE602006009940D1 (fr)
DK (1) DK1904502T3 (fr)
ES (1) ES2334712T3 (fr)
IL (1) IL187917A (fr)
MX (1) MX2008000497A (fr)
NO (1) NO341172B1 (fr)
PT (1) PT1904502E (fr)
RU (1) RU2422447C2 (fr)
WO (1) WO2007011835A2 (fr)
ZA (1) ZA200710688B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
US9890132B2 (en) 2013-08-25 2018-02-13 Council Of Scientific & Industrial Research Process for the preparation of anti-inflammatory aroylbenzofuran compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
FR2550091B1 (fr) 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
US5175187A (en) 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
WO1990007330A1 (fr) 1989-01-06 1990-07-12 The Regents Of The University Of California Procede de selection de composes pharmaceutiques specifiques utiles
US4931464A (en) 1989-02-15 1990-06-05 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
US4962095A (en) 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
FR2653431B1 (fr) * 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2853404B2 (ja) * 1990-10-05 1999-02-03 味の素株式会社 抗不整脈薬
SE9101509D0 (sv) 1991-05-17 1991-05-17 Karobio Ab Receptor ligands
US6316487B1 (en) * 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
US5364880A (en) 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6683195B2 (en) 1999-10-15 2004-01-27 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
WO2001029018A2 (fr) 1999-10-15 2001-04-26 Aryx Therapeutics Nouveaux composes enantiomeres pour le traitement des arythmies cardiaques et procedes d'utilisation
US6372783B1 (en) 1999-10-15 2002-04-16 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
NL1015686C2 (nl) 2000-07-12 2002-01-15 Dsm Nv Werkwijze voor het met laserbestraling irreversibel aanbrengen van een voor het naakte oog onzichtbare markering op een polymeer vormdeel.
JP2005516010A (ja) 2001-12-10 2005-06-02 アリックス セラピューティクス 心不整脈治療のための化合物、合成および使用法

Also Published As

Publication number Publication date
IL187917A (en) 2015-04-30
US7498449B2 (en) 2009-03-03
NO341172B1 (no) 2017-09-04
WO2007011835A2 (fr) 2007-01-25
IL187917A0 (en) 2008-03-20
NO20080828L (no) 2008-02-15
WO2007011835A3 (fr) 2007-03-29
EP1904502B1 (fr) 2009-10-21
CN101248079A (zh) 2008-08-20
AU2006270086B2 (en) 2012-12-13
EP2145881A1 (fr) 2010-01-20
BRPI0613047A2 (pt) 2010-12-14
CA2612599C (fr) 2015-01-06
KR20080040645A (ko) 2008-05-08
AU2006270086A1 (en) 2007-01-25
US20070060640A1 (en) 2007-03-15
ATE446300T1 (de) 2009-11-15
PT1904502E (pt) 2009-12-15
JP2009501723A (ja) 2009-01-22
EP1904502A2 (fr) 2008-04-02
CA2612599A1 (fr) 2007-01-25
CY1109613T1 (el) 2014-08-13
BRPI0613047A8 (pt) 2018-01-02
DE602006009940D1 (de) 2009-12-03
DK1904502T3 (da) 2009-12-07
ES2334712T3 (es) 2010-03-15
RU2008105757A (ru) 2009-08-20
MX2008000497A (es) 2008-04-17
RU2422447C2 (ru) 2011-06-27

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