ZA200710218B - Mitotic kinesin inhibitors and methods of use thereof - Google Patents

Mitotic kinesin inhibitors and methods of use thereof

Info

Publication number
ZA200710218B
ZA200710218B ZA200710218A ZA200710218A ZA200710218B ZA 200710218 B ZA200710218 B ZA 200710218B ZA 200710218 A ZA200710218 A ZA 200710218A ZA 200710218 A ZA200710218 A ZA 200710218A ZA 200710218 B ZA200710218 B ZA 200710218B
Authority
ZA
South Africa
Prior art keywords
methods
mitotic kinesin
kinesin inhibitors
inhibitors
mitotic
Prior art date
Application number
ZA200710218A
Other languages
English (en)
Inventor
Hans Jeremy
Zhao Qian
Laird Ellen
John E Robinson
Delisle Robert Kirk
Eli M Wallace
Allen Shelley
Joseph P Lyssikatos
Christopher P Corrette
Voegtli Walter Charles
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of ZA200710218B publication Critical patent/ZA200710218B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D419/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • C07F9/65392Five-membered rings containing two nitrogen atoms
    • C07F9/65395Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fertilizers (AREA)
ZA200710218A 2005-05-02 2007-11-27 Mitotic kinesin inhibitors and methods of use thereof ZA200710218B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67689005P 2005-05-02 2005-05-02

Publications (1)

Publication Number Publication Date
ZA200710218B true ZA200710218B (en) 2009-07-29

Family

ID=37308299

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710218A ZA200710218B (en) 2005-05-02 2007-11-27 Mitotic kinesin inhibitors and methods of use thereof

Country Status (16)

Country Link
US (5) US7795282B2 (enExample)
EP (1) EP1879886B1 (enExample)
JP (1) JP2008540418A (enExample)
KR (1) KR101329901B1 (enExample)
CN (1) CN101248068A (enExample)
AU (1) AU2006242380A1 (enExample)
BR (1) BRPI0610193A2 (enExample)
CA (1) CA2606708C (enExample)
IL (1) IL186707A (enExample)
MX (1) MX2007013539A (enExample)
NO (1) NO20076186L (enExample)
RU (1) RU2007144612A (enExample)
TW (1) TW200716153A (enExample)
UA (1) UA95907C2 (enExample)
WO (1) WO2006119146A1 (enExample)
ZA (1) ZA200710218B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
UA95907C2 (en) * 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
CL2008003063A1 (es) * 2007-10-19 2010-01-04 Schering Corp Compuestos derivados de 1,3,4-tiadiazol espiro condensado, inhibidores de la actividad quinesina ksp; composicion farmaceutica; y su uso en el tratamiento de enfermedades proliferativas tales como el cancer, hiperplasia, hipertrofia cardiaca, enfermedades autoinmune, trastornos fungicos, artritis, rechazo a imjertos, entre otras.
US9561214B2 (en) * 2008-10-16 2017-02-07 Array Biopharma Inc. Method of treatment using inhibitors of mitosis
DE102009058280A1 (de) 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
EP2455456A1 (en) 2010-11-22 2012-05-23 Institut Curie Use of kinesin inhibitors in HIV infection treatment and a method for screening them
EP3230259B1 (en) 2014-12-08 2024-04-03 The Research Foundation for The State University of New York Anti-fungals targeting the synthesis of fungal shingolipids
US11414378B2 (en) 2017-06-16 2022-08-16 The Research Foundation For The State University Of New York Anti-fungals compounds targeting the synthesis of fungal sphingolipids
JP2023537052A (ja) * 2020-08-07 2023-08-30 イタルファルマコ ソシエタ ペル アチオニ 新規オキサジアゾール系の選択的hdac6阻害剤
CN114014824B (zh) * 2020-12-09 2023-06-13 上海科技大学 一种杂环化合物的应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2702803A (en) 1954-04-12 1955-02-22 Lilly Co Eli Substituted heterodiazoles
ATE72431T1 (de) 1985-08-31 1992-02-15 Fisons Plc 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
GB8625774D0 (en) 1986-10-28 1986-12-03 Reckitt & Colmann Prod Ltd Thiadiazole derivative
JPH0572686A (ja) 1991-09-11 1993-03-26 Konica Corp ハロゲン化銀写真感光材料
AU4288293A (en) * 1992-04-27 1993-11-29 E.I. Du Pont De Nemours And Company Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
US6159938A (en) 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
WO1996023769A2 (en) 1995-02-02 1996-08-08 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht2c receptor antagonist activity
US5958957A (en) 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US5668159A (en) 1996-05-08 1997-09-16 The Dupont Merck Pharmaceutical Company 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
HRP980093A2 (en) 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds
NZ503981A (en) 1997-12-16 2002-12-20 Warner Lambert Co Novel amines, pharmaceutical compositions containing these amines, and uses thereof
JP2000159756A (ja) 1998-11-23 2000-06-13 American Cyanamid Co 2―アリ―ル―δ2―1,3,4―(オキサおよびチア)ジアゾリン殺虫および殺ダニ剤
US6235762B1 (en) 1998-11-23 2001-05-22 American Cyanamid Company 2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents
US6380187B2 (en) 1999-03-25 2002-04-30 Dingwei Tim Yu Class of thiomorpholino substituted thiazoles
WO2001056994A1 (en) 2000-02-04 2001-08-09 Biogen, Inc. Integrin antagonists
US6284480B1 (en) 2000-04-03 2001-09-04 Cytokinetics, Inc. Antifungal assay
EP1419770A4 (en) 2001-08-24 2005-08-03 Shionogi & Co AGENT ACC L RATION OF THE EXPRESSION OF APO AI
RU2004116063A (ru) * 2001-10-22 2005-03-27 Аутсайд Ин (CH) Тара и тарное устройство для сигарет
DK1847534T3 (da) 2001-12-11 2011-08-29 Kyowa Hakko Kirin Co Ltd Thiadiazolin-derivater til behandling af kræft
CA2478068C (en) * 2002-03-08 2011-02-08 Merck & Co., Inc. Dihydropyrazole compounds useful for treating or preventing cancer
US20050004186A1 (en) 2002-12-20 2005-01-06 Pfizer Inc MEK inhibiting compounds
US20040167188A1 (en) 2003-02-14 2004-08-26 Zhili Xin Protein-tyrosine phosphatase inhibitors and uses thereof
MXPA05009459A (es) * 2003-03-03 2006-05-17 Array Biopharma Inc Inhibidores de p38 y sus metodos de uso.
CN1774428B (zh) 2003-04-18 2010-06-16 协和发酵麒麟株式会社 M期驱动蛋白抑制剂
US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
BRPI0410348A (pt) 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US20050009877A1 (en) 2003-05-15 2005-01-13 Henry Lu Methods of identifying HCV NS5B polymerase inhibitors and their uses
JPWO2004111024A1 (ja) 2003-06-10 2006-07-20 協和醗酵工業株式会社 チアジアゾリン誘導体
WO2004111023A1 (ja) 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン-1-オキシド誘導体
JP2007502775A (ja) 2003-08-15 2007-02-15 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
EP1671957A4 (en) * 2003-10-10 2007-03-14 THIADIAZOLINDERIVATE
JP2005232016A (ja) 2004-02-17 2005-09-02 Kyowa Hakko Kogyo Co Ltd オキサジアゾリン誘導体
GB0406867D0 (en) 2004-03-26 2004-04-28 F2G Ltd Antifungal agents
EP1781286A4 (en) 2004-08-18 2009-06-10 Merck & Co Inc INHIBITORS OF MITOTIC KINESINE
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
WO2006050962A1 (en) * 2004-11-10 2006-05-18 Basf Aktiengesellschaft A method of regenerating a catalyst
UA95907C2 (en) * 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
WO2008042928A2 (en) 2006-10-03 2008-04-10 Array Biopharma, Inc. Oxadiazole and thiadiazole derivatives as mitotic kinesin inhibitors and methods of use thereof
US10174390B2 (en) 2006-10-03 2019-01-08 Gary M. Cola, JR. Microtreatment of iron-based alloy, apparatus and method therefor, and articles resulting therefrom

Also Published As

Publication number Publication date
KR101329901B1 (ko) 2013-11-14
IL186707A (en) 2013-04-30
US20060247178A1 (en) 2006-11-02
AU2006242380A1 (en) 2006-11-09
RU2007144612A (ru) 2009-06-10
US8580828B2 (en) 2013-11-12
WO2006119146A1 (en) 2006-11-09
CA2606708C (en) 2015-01-06
US7795282B2 (en) 2010-09-14
UA95907C2 (en) 2011-09-26
BRPI0610193A2 (pt) 2010-06-01
EP1879886A1 (en) 2008-01-23
US20100331283A1 (en) 2010-12-30
KR20080003934A (ko) 2008-01-08
MX2007013539A (es) 2008-01-24
CN101248068A (zh) 2008-08-20
US8268871B2 (en) 2012-09-18
TW200716153A (en) 2007-05-01
JP2008540418A (ja) 2008-11-20
US20150191490A1 (en) 2015-07-09
US20130109656A1 (en) 2013-05-02
EP1879886B1 (en) 2014-07-09
US20140018399A1 (en) 2014-01-16
NO20076186L (no) 2008-02-01
CA2606708A1 (en) 2006-11-09
US9221841B2 (en) 2015-12-29
EP1879886A4 (en) 2010-09-08
HK1115376A1 (en) 2008-11-28
AU2006242380A2 (en) 2008-07-03
IL186707A0 (en) 2008-02-09

Similar Documents

Publication Publication Date Title
IL188932A0 (en) Sphingosine kinase inhibitors and methods of their use
ZA200802485B (en) Phosphatidylinositol 3-kinase inhibitors and methods of their use
ZA200710218B (en) Mitotic kinesin inhibitors and methods of use thereof
IL182203A0 (en) Thiadiazole compounds and methods of use
IL182734A0 (en) 4-aminotetracyclines and methods of use thereof
IL176958A0 (en) Compounds and methods of use
ZA201203844B (en) Heterocyclic inhibitors of mek and methods of use thereof
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
ZA200704888B (en) Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases
IL198397A0 (en) Anilinopiperazine derivatives and methods of use thereof
IL197060A0 (en) Aza-benzothiophenyl compounds and methods of use
EP2023718A4 (en) CREATINLIGATE COMPOUNDS AND APPLICATION METHOD THEREFOR
EP1949105A4 (en) MARKERS ASSOCIATED WITH DIABETES AND METHODS OF USE THEREOF
IL174431A0 (en) Substituted benzazoles and use thereof as inhibitors of raf kinase
IL181524A0 (en) Heterocyclic compounds and methods of use
IL189771A0 (en) Raf inhibitor compounds and methods of use thereof
ZA200808017B (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
IL185309A0 (en) Isoqunoline compounds and methods of use thereof
EP1817277A4 (en) PHENYL DERIVATIVES AND METHOD OF USE
EP1868601A4 (en) MITOTIC KINESINE HEMMER
EP1812451A4 (en) COMPOUNDS AND METHODS OF USE THEREOF
EP1789437A4 (en) INHIBITORS OF NPC1L1 AND NPC1L1 AND METHODS OF USE THEREOF
IL186120A0 (en) Inhibitors of neurotrypsin and determination thereof
EP1877424A4 (en) INHIBITORS OF PROTEIN KINASES AND USES THEREOF
EP1781286A4 (en) INHIBITORS OF MITOTIC KINESINE