JP2008540418A - 有糸分裂キネシンおよびその使用方法 - Google Patents
有糸分裂キネシンおよびその使用方法 Download PDFInfo
- Publication number
- JP2008540418A JP2008540418A JP2008510090A JP2008510090A JP2008540418A JP 2008540418 A JP2008540418 A JP 2008540418A JP 2008510090 A JP2008510090 A JP 2008510090A JP 2008510090 A JP2008510090 A JP 2008510090A JP 2008540418 A JP2008540418 A JP 2008540418A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- phenyl
- thiadiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(*=C)(C(*)=N1)SC1=O Chemical compound *C(*=C)(C(*)=N1)SC1=O 0.000 description 18
- HQAKKLXGGLTNBU-UHFFFAOYSA-N CC(C)(C(SCC1(C)C)=NC1=O)NC Chemical compound CC(C)(C(SCC1(C)C)=NC1=O)NC HQAKKLXGGLTNBU-UHFFFAOYSA-N 0.000 description 1
- RYOFRMNEQYSKRG-UHFFFAOYSA-N CC(C)C(OC(C)=C1)=NS1(=O)=O Chemical compound CC(C)C(OC(C)=C1)=NS1(=O)=O RYOFRMNEQYSKRG-UHFFFAOYSA-N 0.000 description 1
- ZQCMUFVIUREOKW-UHFFFAOYSA-N CC(S1)=NN(C)C1=O Chemical compound CC(S1)=NN(C)C1=O ZQCMUFVIUREOKW-UHFFFAOYSA-N 0.000 description 1
- FDZAXFWKKSGFGO-UHFFFAOYSA-N CCC(SC(C)=C1)=NS1(=O)=O Chemical compound CCC(SC(C)=C1)=NS1(=O)=O FDZAXFWKKSGFGO-UHFFFAOYSA-N 0.000 description 1
- INFQYUDBHPFNDN-UHFFFAOYSA-N CN(C)C(c1c[s]c(N2N=C(c3cc(F)ccc3F)SC2(CCCN)c2ccccc2)n1)=O Chemical compound CN(C)C(c1c[s]c(N2N=C(c3cc(F)ccc3F)SC2(CCCN)c2ccccc2)n1)=O INFQYUDBHPFNDN-UHFFFAOYSA-N 0.000 description 1
- VWLHFPYDMKSVGD-UHFFFAOYSA-N Cc(nc(C)nc1)c1F Chemical compound Cc(nc(C)nc1)c1F VWLHFPYDMKSVGD-UHFFFAOYSA-N 0.000 description 1
- HZCNQXBKLSTLFW-UHFFFAOYSA-N Cc1c[n](ccc(I)n2)c2n1 Chemical compound Cc1c[n](ccc(I)n2)c2n1 HZCNQXBKLSTLFW-UHFFFAOYSA-N 0.000 description 1
- DTVNFCGXTGMYMM-UHFFFAOYSA-N Cc1cc2ncc[n]2nc1 Chemical compound Cc1cc2ncc[n]2nc1 DTVNFCGXTGMYMM-UHFFFAOYSA-N 0.000 description 1
- MYCDLLAVPSEMGA-UHFFFAOYSA-N Cc1nc(C#N)ccn1 Chemical compound Cc1nc(C#N)ccn1 MYCDLLAVPSEMGA-UHFFFAOYSA-N 0.000 description 1
- ZVKPJTWOJJEJFA-UHFFFAOYSA-N Cc1nc(CCCCCC2)c2[s]1 Chemical compound Cc1nc(CCCCCC2)c2[s]1 ZVKPJTWOJJEJFA-UHFFFAOYSA-N 0.000 description 1
- OWXYCCOFAWKZPF-UHFFFAOYSA-N Cc1nc([N+]([O-])=O)ccn1 Chemical compound Cc1nc([N+]([O-])=O)ccn1 OWXYCCOFAWKZPF-UHFFFAOYSA-N 0.000 description 1
- XEKAIOBTURCGKZ-UHFFFAOYSA-N Cc1nccc(C(N(C)C)=O)n1 Chemical compound Cc1nccc(C(N(C)C)=O)n1 XEKAIOBTURCGKZ-UHFFFAOYSA-N 0.000 description 1
- QBIFTEIVPCDEDY-UHFFFAOYSA-N NCCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1ncc[s]1 Chemical compound NCCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1ncc[s]1 QBIFTEIVPCDEDY-UHFFFAOYSA-N 0.000 description 1
- MRFMKVLOAVTAHC-UHFFFAOYSA-N NCCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1nnc(-c2ccccc2)[nH]1 Chemical compound NCCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1nnc(-c2ccccc2)[nH]1 MRFMKVLOAVTAHC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/65392—Five-membered rings containing two nitrogen atoms
- C07F9/65395—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67689005P | 2005-05-02 | 2005-05-02 | |
| PCT/US2006/016526 WO2006119146A1 (en) | 2005-05-02 | 2006-05-01 | Mitotic kinesin inhibitors and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540418A true JP2008540418A (ja) | 2008-11-20 |
| JP2008540418A5 JP2008540418A5 (enExample) | 2012-04-05 |
Family
ID=37308299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510090A Pending JP2008540418A (ja) | 2005-05-02 | 2006-05-01 | 有糸分裂キネシンおよびその使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7795282B2 (enExample) |
| EP (1) | EP1879886B1 (enExample) |
| JP (1) | JP2008540418A (enExample) |
| KR (1) | KR101329901B1 (enExample) |
| CN (1) | CN101248068A (enExample) |
| AU (1) | AU2006242380A1 (enExample) |
| BR (1) | BRPI0610193A2 (enExample) |
| CA (1) | CA2606708C (enExample) |
| IL (1) | IL186707A (enExample) |
| MX (1) | MX2007013539A (enExample) |
| NO (1) | NO20076186L (enExample) |
| RU (1) | RU2007144612A (enExample) |
| TW (1) | TW200716153A (enExample) |
| UA (1) | UA95907C2 (enExample) |
| WO (1) | WO2006119146A1 (enExample) |
| ZA (1) | ZA200710218B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| UA95907C2 (en) * | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| CL2008003063A1 (es) * | 2007-10-19 | 2010-01-04 | Schering Corp | Compuestos derivados de 1,3,4-tiadiazol espiro condensado, inhibidores de la actividad quinesina ksp; composicion farmaceutica; y su uso en el tratamiento de enfermedades proliferativas tales como el cancer, hiperplasia, hipertrofia cardiaca, enfermedades autoinmune, trastornos fungicos, artritis, rechazo a imjertos, entre otras. |
| US9561214B2 (en) * | 2008-10-16 | 2017-02-07 | Array Biopharma Inc. | Method of treatment using inhibitors of mitosis |
| DE102009058280A1 (de) | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | Thiazolderivate |
| EP2455456A1 (en) | 2010-11-22 | 2012-05-23 | Institut Curie | Use of kinesin inhibitors in HIV infection treatment and a method for screening them |
| EP3230259B1 (en) | 2014-12-08 | 2024-04-03 | The Research Foundation for The State University of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| US11414378B2 (en) | 2017-06-16 | 2022-08-16 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
| JP2023537052A (ja) * | 2020-08-07 | 2023-08-30 | イタルファルマコ ソシエタ ペル アチオニ | 新規オキサジアゾール系の選択的ｈｄａｃ６阻害剤 |
| CN114014824B (zh) * | 2020-12-09 | 2023-06-13 | 上海科技大学 | 一种杂环化合物的应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022311A1 (en) * | 1992-04-27 | 1993-11-11 | E.I. Du Pont De Nemours And Company | Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines |
| WO2003035512A1 (en) * | 2001-10-22 | 2003-05-01 | Outside In | Self dispensing cigarette pack |
| WO2003079973A2 (en) * | 2002-03-08 | 2003-10-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| JP2008510013A (ja) * | 2004-08-18 | 2008-04-03 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| JP2008519682A (ja) * | 2004-11-10 | 2008-06-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 触媒の再生方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2702803A (en) | 1954-04-12 | 1955-02-22 | Lilly Co Eli | Substituted heterodiazoles |
| ATE72431T1 (de) | 1985-08-31 | 1992-02-15 | Fisons Plc | 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren. |
| GB8625774D0 (en) | 1986-10-28 | 1986-12-03 | Reckitt & Colmann Prod Ltd | Thiadiazole derivative |
| JPH0572686A (ja) | 1991-09-11 | 1993-03-26 | Konica Corp | ハロゲン化銀写真感光材料 |
| US6159938A (en) | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| WO1996023769A2 (en) | 1995-02-02 | 1996-08-08 | Smithkline Beecham Plc | Heterocyclic compounds possessing 5ht2c receptor antagonist activity |
| US5958957A (en) | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| US5668159A (en) | 1996-05-08 | 1997-09-16 | The Dupont Merck Pharmaceutical Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists |
| HRP980093A2 (en) | 1997-02-28 | 1998-12-31 | Lilly Co Eli | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds |
| NZ503981A (en) | 1997-12-16 | 2002-12-20 | Warner Lambert Co | Novel amines, pharmaceutical compositions containing these amines, and uses thereof |
| JP2000159756A (ja) | 1998-11-23 | 2000-06-13 | American Cyanamid Co | ２―アリ―ル―δ２―１，３，４―（オキサおよびチア）ジアゾリン殺虫および殺ダニ剤 |
| US6235762B1 (en) | 1998-11-23 | 2001-05-22 | American Cyanamid Company | 2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents |
| US6380187B2 (en) | 1999-03-25 | 2002-04-30 | Dingwei Tim Yu | Class of thiomorpholino substituted thiazoles |
| WO2001056994A1 (en) | 2000-02-04 | 2001-08-09 | Biogen, Inc. | Integrin antagonists |
| US6284480B1 (en) | 2000-04-03 | 2001-09-04 | Cytokinetics, Inc. | Antifungal assay |
| EP1419770A4 (en) | 2001-08-24 | 2005-08-03 | Shionogi & Co | AGENT ACC L RATION OF THE EXPRESSION OF APO AI |
| DK1847534T3 (da) | 2001-12-11 | 2011-08-29 | Kyowa Hakko Kirin Co Ltd | Thiadiazolin-derivater til behandling af kræft |
| US20050004186A1 (en) | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
| US20040167188A1 (en) | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| MXPA05009459A (es) * | 2003-03-03 | 2006-05-17 | Array Biopharma Inc | Inhibidores de p38 y sus metodos de uso. |
| CN1774428B (zh) | 2003-04-18 | 2010-06-16 | 协和发酵麒麟株式会社 | M期驱动蛋白抑制剂 |
| US7326790B2 (en) | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
| US7115642B2 (en) | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
| US20050075375A1 (en) | 2003-05-14 | 2005-04-07 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis C virus |
| BRPI0410348A (pt) | 2003-05-14 | 2006-05-30 | Torreypines Therapeutics Inc | compostos e usos dos mesmos na modulação de amilóide-beta |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| US20050009877A1 (en) | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
| JPWO2004111024A1 (ja) | 2003-06-10 | 2006-07-20 | 協和醗酵工業株式会社 | チアジアゾリン誘導体 |
| WO2004111023A1 (ja) | 2003-06-10 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | チアジアゾリン－１－オキシド誘導体 |
| JP2007502775A (ja) | 2003-08-15 | 2007-02-15 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| EP1671957A4 (en) * | 2003-10-10 | 2007-03-14 | THIADIAZOLINDERIVATE | |
| JP2005232016A (ja) | 2004-02-17 | 2005-09-02 | Kyowa Hakko Kogyo Co Ltd | オキサジアゾリン誘導体 |
| GB0406867D0 (en) | 2004-03-26 | 2004-04-28 | F2G Ltd | Antifungal agents |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| UA95907C2 (en) * | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| WO2008042928A2 (en) | 2006-10-03 | 2008-04-10 | Array Biopharma, Inc. | Oxadiazole and thiadiazole derivatives as mitotic kinesin inhibitors and methods of use thereof |
| US10174390B2 (en) | 2006-10-03 | 2019-01-08 | Gary M. Cola, JR. | Microtreatment of iron-based alloy, apparatus and method therefor, and articles resulting therefrom |
-
2006
- 2006-01-05 UA UAA200713355A patent/UA95907C2/ru unknown
- 2006-05-01 CA CA2606708A patent/CA2606708C/en not_active Expired - Fee Related
- 2006-05-01 WO PCT/US2006/016526 patent/WO2006119146A1/en not_active Ceased
- 2006-05-01 AU AU2006242380A patent/AU2006242380A1/en not_active Abandoned
- 2006-05-01 EP EP06758821.0A patent/EP1879886B1/en active Active
- 2006-05-01 JP JP2008510090A patent/JP2008540418A/ja active Pending
- 2006-05-01 US US11/415,455 patent/US7795282B2/en not_active Expired - Fee Related
- 2006-05-01 CN CNA2006800242288A patent/CN101248068A/zh active Pending
- 2006-05-01 BR BRPI0610193-3A patent/BRPI0610193A2/pt not_active IP Right Cessation
- 2006-05-01 RU RU2007144612/04A patent/RU2007144612A/ru not_active Application Discontinuation
- 2006-05-01 KR KR1020077027972A patent/KR101329901B1/ko not_active Expired - Fee Related
- 2006-05-01 MX MX2007013539A patent/MX2007013539A/es not_active Application Discontinuation
- 2006-05-02 TW TW095115570A patent/TW200716153A/zh unknown
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2007
- 2007-10-17 IL IL186707A patent/IL186707A/en active IP Right Grant
- 2007-11-27 ZA ZA200710218A patent/ZA200710218B/xx unknown
- 2007-11-30 NO NO20076186A patent/NO20076186L/no not_active Application Discontinuation
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2010
- 2010-06-23 US US12/822,066 patent/US8268871B2/en not_active Expired - Fee Related
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2012
- 2012-08-15 US US13/586,355 patent/US8580828B2/en not_active Expired - Fee Related
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2013
- 2013-09-19 US US14/031,958 patent/US20140018399A1/en not_active Abandoned
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2015
- 2015-03-19 US US14/663,286 patent/US9221841B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022311A1 (en) * | 1992-04-27 | 1993-11-11 | E.I. Du Pont De Nemours And Company | Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines |
| WO2003035512A1 (en) * | 2001-10-22 | 2003-05-01 | Outside In | Self dispensing cigarette pack |
| WO2003079973A2 (en) * | 2002-03-08 | 2003-10-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| JP2008510013A (ja) * | 2004-08-18 | 2008-04-03 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| JP2008519682A (ja) * | 2004-11-10 | 2008-06-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 触媒の再生方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101329901B1 (ko) | 2013-11-14 |
| IL186707A (en) | 2013-04-30 |
| US20060247178A1 (en) | 2006-11-02 |
| AU2006242380A1 (en) | 2006-11-09 |
| RU2007144612A (ru) | 2009-06-10 |
| US8580828B2 (en) | 2013-11-12 |
| WO2006119146A1 (en) | 2006-11-09 |
| CA2606708C (en) | 2015-01-06 |
| US7795282B2 (en) | 2010-09-14 |
| UA95907C2 (en) | 2011-09-26 |
| BRPI0610193A2 (pt) | 2010-06-01 |
| EP1879886A1 (en) | 2008-01-23 |
| US20100331283A1 (en) | 2010-12-30 |
| KR20080003934A (ko) | 2008-01-08 |
| MX2007013539A (es) | 2008-01-24 |
| CN101248068A (zh) | 2008-08-20 |
| ZA200710218B (en) | 2009-07-29 |
| US8268871B2 (en) | 2012-09-18 |
| TW200716153A (en) | 2007-05-01 |
| US20150191490A1 (en) | 2015-07-09 |
| US20130109656A1 (en) | 2013-05-02 |
| EP1879886B1 (en) | 2014-07-09 |
| US20140018399A1 (en) | 2014-01-16 |
| NO20076186L (no) | 2008-02-01 |
| CA2606708A1 (en) | 2006-11-09 |
| US9221841B2 (en) | 2015-12-29 |
| EP1879886A4 (en) | 2010-09-08 |
| HK1115376A1 (en) | 2008-11-28 |
| AU2006242380A2 (en) | 2008-07-03 |
| IL186707A0 (en) | 2008-02-09 |
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| Publication | Publication Date | Title |
|---|---|---|
| JP5757666B2 (ja) | 有糸分裂キネシン阻害剤およびその使用方法 | |
| US9221841B2 (en) | Mitotic kinesin inhibitors and methods of use thereof | |
| HK1115376B (en) | Inhibitors of mitotic kinesins and their therapeutical use |
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