ZA200707142B - Quinolinone compounds as 5-HT4 receptor agonists - Google Patents

Quinolinone compounds as 5-HT4 receptor agonists

Info

Publication number
ZA200707142B
ZA200707142B ZA200707142A ZA200707142A ZA200707142B ZA 200707142 B ZA200707142 B ZA 200707142B ZA 200707142 A ZA200707142 A ZA 200707142A ZA 200707142 A ZA200707142 A ZA 200707142A ZA 200707142 B ZA200707142 B ZA 200707142B
Authority
ZA
South Africa
Prior art keywords
receptor agonists
quinolinone compounds
quinolinone
compounds
agonists
Prior art date
Application number
ZA200707142A
Other languages
English (en)
Inventor
Goldblum Adam
Paul R Fatheree
Jiang Lan
Marquess Daniel
Choi Seok-Ki
Roland Gendron
Long Daniel
Derek S Turner
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of ZA200707142B publication Critical patent/ZA200707142B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200707142A 2005-03-02 2007-08-23 Quinolinone compounds as 5-HT4 receptor agonists ZA200707142B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65800705P 2005-03-02 2005-03-02

Publications (1)

Publication Number Publication Date
ZA200707142B true ZA200707142B (en) 2008-10-29

Family

ID=36588769

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200707142A ZA200707142B (en) 2005-03-02 2007-08-23 Quinolinone compounds as 5-HT4 receptor agonists

Country Status (16)

Country Link
US (2) US7446114B2 (es)
EP (1) EP1871772B1 (es)
JP (1) JP5042043B2 (es)
KR (1) KR20070107807A (es)
CN (1) CN101163701A (es)
AU (1) AU2006218603A1 (es)
BR (1) BRPI0608392A2 (es)
CA (1) CA2599404A1 (es)
EA (1) EA013567B1 (es)
ES (1) ES2523851T3 (es)
IL (1) IL185407A0 (es)
MX (1) MX2007010769A (es)
NO (1) NO20074884L (es)
NZ (1) NZ560828A (es)
WO (1) WO2006094063A1 (es)
ZA (1) ZA200707142B (es)

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TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
TWI377206B (en) 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
JP5265513B2 (ja) * 2007-02-19 2013-08-14 株式会社カネカ 光学活性３−アミノピペリジン又はその塩の製造方法
SG178557A1 (en) * 2009-09-14 2012-03-29 Suven Life Sciences Ltd L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands
TW201642856A (zh) * 2015-04-02 2016-12-16 施萬生物製藥研發Ｉｐ有限責任公司 Ｍｕ類鴉片受體拮抗劑與類鴉片藥劑之組合劑型
WO2023135508A1 (en) 2022-01-11 2023-07-20 Suven Life Sciences Limited PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

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Also Published As

Publication number Publication date
NO20074884L (no) 2007-11-29
US7875629B2 (en) 2011-01-25
AU2006218603A1 (en) 2006-09-08
ES2523851T3 (es) 2014-12-02
BRPI0608392A2 (pt) 2009-12-29
IL185407A0 (en) 2008-01-06
MX2007010769A (es) 2008-03-07
JP2008531711A (ja) 2008-08-14
WO2006094063A1 (en) 2006-09-08
JP5042043B2 (ja) 2012-10-03
CA2599404A1 (en) 2006-09-08
NZ560828A (en) 2011-01-28
US20060199839A1 (en) 2006-09-07
EP1871772B1 (en) 2014-09-10
US20090036483A1 (en) 2009-02-05
EA200701867A1 (ru) 2008-02-28
CN101163701A (zh) 2008-04-16
EP1871772A1 (en) 2008-01-02
KR20070107807A (ko) 2007-11-07
US7446114B2 (en) 2008-11-04
EA013567B1 (ru) 2010-06-30

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