ZA200705123B - Rapamycin derivatives and the uses thereof in the treatment of neurological disorders - Google Patents
Rapamycin derivatives and the uses thereof in the treatment of neurological disordersInfo
- Publication number
- ZA200705123B ZA200705123B ZA200705123A ZA200705123A ZA200705123B ZA 200705123 B ZA200705123 B ZA 200705123B ZA 200705123 A ZA200705123 A ZA 200705123A ZA 200705123 A ZA200705123 A ZA 200705123A ZA 200705123 B ZA200705123 B ZA 200705123B
- Authority
- ZA
- South Africa
- Prior art keywords
- treatment
- neurological disorders
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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-
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63800404P | 2004-12-20 | 2004-12-20 | |
PCT/US2005/045331 WO2006068905A2 (en) | 2004-12-20 | 2005-12-15 | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200705123B true ZA200705123B (en) | 2010-01-27 |
Family
ID=36602218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200705123A ZA200705123B (en) | 2004-12-20 | 2007-06-19 | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
Country Status (16)
Country | Link |
---|---|
US (3) | US7273874B2 (xx) |
EP (1) | EP1828203A2 (xx) |
JP (1) | JP2008524232A (xx) |
KR (1) | KR20070090931A (xx) |
CN (1) | CN101084226A (xx) |
AU (1) | AU2005319427B2 (xx) |
BR (1) | BRPI0519593A2 (xx) |
CA (1) | CA2590254A1 (xx) |
CR (1) | CR9149A (xx) |
IL (1) | IL183772A0 (xx) |
MX (1) | MX2007007409A (xx) |
NI (1) | NI200700156A (xx) |
NO (1) | NO20072665L (xx) |
RU (1) | RU2007119585A (xx) |
WO (1) | WO2006068905A2 (xx) |
ZA (1) | ZA200705123B (xx) |
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KR101131794B1 (ko) * | 2002-07-30 | 2012-03-30 | 와이어쓰 엘엘씨 | Cci-779 공용매 농축액, 비경구 cci-779 제형 및 비경구 cci-779 제형의 제조방법 |
CA2556622A1 (en) * | 2004-03-02 | 2005-09-15 | Wyeth | Macrolides and methods for producing same |
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MX2007007409A (es) * | 2004-12-20 | 2007-07-12 | Wyeth Corp | Derivados de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos. |
ES2380779T3 (es) * | 2004-12-20 | 2012-05-18 | Wyeth Llc | Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios |
WO2006096529A2 (en) * | 2005-03-07 | 2006-09-14 | Novartis Ag | Genes involved in neurodegenerative conditions |
KR20080077618A (ko) * | 2005-12-07 | 2008-08-25 | 와이어쓰 | 정제된 결정체 cci-779 의 제조 방법 |
KR20080077147A (ko) * | 2005-12-07 | 2008-08-21 | 와이어쓰 | 결정성 라파마이신의 제조 방법 및 시차 주사 열량계를사용하는 라파마이신 화합물의 결정화도의 측정 방법 |
WO2007067560A2 (en) * | 2005-12-07 | 2007-06-14 | Wyeth | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
CA2643350A1 (en) | 2006-03-07 | 2007-09-13 | Wyeth | Meridamycin analogues for the treatment of neurodegenerative disorders |
TW200824713A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
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US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
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US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
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CA2676613A1 (en) * | 2007-01-29 | 2008-08-07 | Wyeth | Immunophilin ligands and methods for modulating immunophilin and calcium channel activity |
JP2008305262A (ja) * | 2007-06-08 | 2008-12-18 | Konica Minolta Business Technologies Inc | サーバ及びシンクライアント環境でのプリンタ紹介方法 |
EP2205249B1 (en) | 2007-09-28 | 2018-11-07 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
US20090209527A1 (en) * | 2008-02-19 | 2009-08-20 | Wyeth | Methods for Using Rapamycin Analogues in the Treatment of Neurological Disorders |
CA2743491C (en) | 2008-11-11 | 2016-10-11 | Zelton Dave Sharp | Inhibition of mammalian target of rapamycin |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
CA2794196A1 (en) | 2010-03-23 | 2011-09-29 | Intrexon Corporation | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
ES2372077B2 (es) * | 2010-06-24 | 2012-05-18 | Universidad De Sevilla | Uso de la rapamicina para el tratamiento de los déficits cognitivos asociados al s�?ndrome de down. |
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CN102274219A (zh) * | 2011-06-27 | 2011-12-14 | 苏州大学附属第一医院 | 雷帕霉素在治疗蛛网膜下腔出血早期脑损伤的应用 |
WO2014059295A1 (en) | 2012-10-12 | 2014-04-17 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
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EP2968281B1 (en) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
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-
2005
- 2005-12-15 MX MX2007007409A patent/MX2007007409A/es active IP Right Grant
- 2005-12-15 CN CNA2005800437050A patent/CN101084226A/zh active Pending
- 2005-12-15 AU AU2005319427A patent/AU2005319427B2/en not_active Ceased
- 2005-12-15 BR BRPI0519593-4A patent/BRPI0519593A2/pt not_active IP Right Cessation
- 2005-12-15 US US11/300,941 patent/US7273874B2/en not_active Expired - Fee Related
- 2005-12-15 CA CA002590254A patent/CA2590254A1/en not_active Abandoned
- 2005-12-15 WO PCT/US2005/045331 patent/WO2006068905A2/en active Application Filing
- 2005-12-15 RU RU2007119585/04A patent/RU2007119585A/ru not_active Application Discontinuation
- 2005-12-15 JP JP2007546876A patent/JP2008524232A/ja active Pending
- 2005-12-15 EP EP05854115A patent/EP1828203A2/en not_active Withdrawn
- 2005-12-15 KR KR1020077013852A patent/KR20070090931A/ko not_active Application Discontinuation
-
2007
- 2007-05-24 CR CR9149A patent/CR9149A/es not_active Application Discontinuation
- 2007-05-25 NO NO20072665A patent/NO20072665L/no not_active Application Discontinuation
- 2007-06-07 IL IL183772A patent/IL183772A0/en unknown
- 2007-06-18 NI NI200700156A patent/NI200700156A/es unknown
- 2007-06-19 ZA ZA200705123A patent/ZA200705123B/xx unknown
- 2007-08-14 US US11/891,879 patent/US7476678B2/en not_active Expired - Fee Related
-
2008
- 2008-12-05 US US12/329,106 patent/US20090088448A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20070090931A (ko) | 2007-09-06 |
US20090088448A1 (en) | 2009-04-02 |
US7273874B2 (en) | 2007-09-25 |
MX2007007409A (es) | 2007-07-12 |
AU2005319427A1 (en) | 2006-06-29 |
US20060135550A1 (en) | 2006-06-22 |
CR9149A (es) | 2007-10-23 |
WO2006068905A2 (en) | 2006-06-29 |
RU2007119585A (ru) | 2009-01-27 |
BRPI0519593A2 (pt) | 2009-02-25 |
NI200700156A (es) | 2008-06-17 |
IL183772A0 (en) | 2007-09-20 |
US7476678B2 (en) | 2009-01-13 |
CA2590254A1 (en) | 2006-06-29 |
CN101084226A (zh) | 2007-12-05 |
NO20072665L (no) | 2007-09-07 |
JP2008524232A (ja) | 2008-07-10 |
US20080027089A1 (en) | 2008-01-31 |
AU2005319427B2 (en) | 2011-11-03 |
WO2006068905A3 (en) | 2006-12-07 |
EP1828203A2 (en) | 2007-09-05 |
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