ZA200701271B - Method of producing a composition, composition and it use - Google Patents
Method of producing a composition, composition and it use Download PDFInfo
- Publication number
- ZA200701271B ZA200701271B ZA200701271A ZA200701271A ZA200701271B ZA 200701271 B ZA200701271 B ZA 200701271B ZA 200701271 A ZA200701271 A ZA 200701271A ZA 200701271 A ZA200701271 A ZA 200701271A ZA 200701271 B ZA200701271 B ZA 200701271B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyruvate
- radical
- composition
- tumour
- hyperpolarised
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 74
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- 229940107700 pyruvic acid Drugs 0.000 claims description 54
- 238000003384 imaging method Methods 0.000 claims description 39
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- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 36
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- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
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- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
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- Medical Informatics (AREA)
- High Energy & Nuclear Physics (AREA)
- Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Rectifiers (AREA)
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| JP (2) | JP5367265B2 (de) |
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| CN (1) | CN101035796B (de) |
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| BR (1) | BRPI0513812B8 (de) |
| CA (1) | CA2575601C (de) |
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| IL (1) | IL180897A (de) |
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| PL (1) | PL1797102T3 (de) |
| RU (1) | RU2374252C2 (de) |
| WO (1) | WO2006011809A1 (de) |
| ZA (1) | ZA200701271B (de) |
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| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| KR20070063504A (ko) * | 2004-07-30 | 2007-06-19 | 지이 헬스케어 에이에스 | 조성물의 제조 방법, 조성물 및 그의 용도 |
| WO2007064226A2 (en) * | 2005-12-01 | 2007-06-07 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| ES2393750T3 (es) | 2005-12-16 | 2012-12-27 | Ge Healthcare As | Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas |
| WO2007111515A2 (en) * | 2006-03-29 | 2007-10-04 | Ge Healthcare As | Method to produce hyperpolarised carboxylates and sulphonates |
| CN101506179B (zh) | 2006-08-30 | 2012-08-22 | 通用电气医疗集团股份有限公司 | 动态核极化(dnp)的方法及用于所述方法的化合物和组合物 |
| WO2008086534A1 (en) | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| KR20100023802A (ko) * | 2007-05-17 | 2010-03-04 | 제너럴 일렉트릭 캄파니 | 과분극화 １３ｃ－피루베이트를 포함하는 영상화 매질을 사용하여 종양을 등급화하는 ｍｒ 방법 |
| US9227173B2 (en) | 2007-06-22 | 2016-01-05 | General Electric Company | Methods for dynamic filtration of pharmaceutical products |
| CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
| EP2902041A1 (de) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR |
| US20110038804A1 (en) * | 2007-12-21 | 2011-02-17 | Anna Gisselsson | Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used |
| WO2009129265A1 (en) | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| US8763410B2 (en) | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| DK2268321T3 (da) | 2008-05-02 | 2013-12-02 | Gen Electric | Fremgangsmåde til bestemmelse af alanintransaminase (alt)-aktivitet ved 13c-mr-detektion under anvendelse af hyperpolariseret 13c-pyruvat |
| RU2543704C2 (ru) | 2009-04-02 | 2015-03-10 | ДжиИ ХЕЛТКЕР ЛИМИТЕД | Применение магнитно-резонансной визуализирующей среды, содержащей гиперполяризованный 13с-пируват, для обнаружения воспаления или инфекции |
| EP2476009A1 (de) | 2009-09-10 | 2012-07-18 | GE Healthcare UK Limited | 13c-mr-detektion mit hyperpolarisierter 13-c-fructose |
| DE102009054956A1 (de) * | 2009-12-18 | 2011-06-22 | Siemens Aktiengesellschaft, 80333 | Magnetresonanztomographie-Bildgebung |
| JP5758982B2 (ja) | 2010-04-08 | 2015-08-05 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | 過分極基質の製造方法およびｍｒｉのための方法 |
| KR101858269B1 (ko) | 2010-05-03 | 2018-05-15 | 지이 헬쓰케어 리미티드 | 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제 |
| US20130149250A1 (en) * | 2011-06-23 | 2013-06-13 | The Regents Of The University Of California | Hyperpolarized agents for mri characterization of redox systems in vivo |
| WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
| EP2950826B1 (de) | 2013-01-31 | 2019-09-18 | Bracco Imaging S.p.A | Hyperpolarisierte ester als stoffwechselmarker in mri |
| EP3016687B1 (de) | 2013-07-01 | 2017-08-09 | Bracco Imaging S.p.A | Hyperpolarisiertes 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropan als stoffwechselmarker für mr |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
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| JP2690987B2 (ja) | 1987-06-23 | 1997-12-17 | ハフスルンド・ニユコメド・イノベイション・アクチェボラーグ | 磁気共鳴像形成における改良 |
| GB8817137D0 (en) | 1988-07-19 | 1988-08-24 | Nycomed As | Compositions |
| AU651570B2 (en) | 1990-02-12 | 1994-07-28 | Hafslund Nycomed Innovation Ab | Triarylmethyl radicals and the use of inert carbon free radicals in MRI |
| US5435991A (en) | 1991-08-09 | 1995-07-25 | Nycomed Innovation Ab | Use of persistent heterocyclic free-radicals in magnetic resonance imaging |
| US5728370A (en) | 1993-04-02 | 1998-03-17 | Nycomed Imaging As | Free Radicals |
| CN1200179A (zh) | 1995-09-08 | 1998-11-25 | 耐克麦德英梅金公司 | 一种测定样品中氧气浓度的方法 |
| ES2201462T3 (es) * | 1997-03-06 | 2004-03-16 | Amersham Health As | Radicales libres de triarilmetilo como agentes mejoradores de la imagen. |
| AU8119298A (en) | 1997-06-19 | 1999-01-04 | Nycomed Imaging As | Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US6232497B1 (en) | 1998-12-23 | 2001-05-15 | Skw Trostberg Aktiengesellschaft | Method for producing alkali metal and alkaline earth metal pyruvates |
| GB0014463D0 (en) | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| KR100794898B1 (ko) | 2000-11-03 | 2008-01-14 | 지이 헬스케어 에이에스 | 분극된 ｎｍｒ 샘플을 위한 방법 및 장치 |
| US6617169B2 (en) * | 2001-03-30 | 2003-09-09 | Mclean Hospital Corporation | Two-dimensional MR spectroscopy techniques |
| US6486671B1 (en) * | 2001-05-14 | 2002-11-26 | Ge Medical Systems Global Technologies Company Llc | MRI image quality improvement using matrix regularization |
| US6958244B2 (en) * | 2002-04-12 | 2005-10-25 | Bruker Biospin Corp. | Low-conductivity buffers for magnetic resonance measurements |
| JP5535435B2 (ja) * | 2004-07-30 | 2014-07-02 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用 |
| KR20070063504A (ko) * | 2004-07-30 | 2007-06-19 | 지이 헬스케어 에이에스 | 조성물의 제조 방법, 조성물 및 그의 용도 |
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2012
- 2012-07-12 JP JP2012156109A patent/JP5745470B2/ja active Active
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| Publication number | Publication date |
|---|---|
| WO2006011809A1 (en) | 2006-02-02 |
| JP5745470B2 (ja) | 2015-07-08 |
| US9023320B2 (en) | 2015-05-05 |
| CA2575601C (en) | 2013-05-28 |
| CA2575601A1 (en) | 2006-02-02 |
| PL1797102T3 (pl) | 2015-10-30 |
| US20080095713A1 (en) | 2008-04-24 |
| BRPI0513812A (pt) | 2008-05-13 |
| US20080213186A1 (en) | 2008-09-04 |
| CN101035796B (zh) | 2011-06-22 |
| RU2007102843A (ru) | 2008-09-10 |
| NZ552898A (en) | 2011-02-25 |
| DK1797102T3 (en) | 2015-08-24 |
| AU2005267668B2 (en) | 2011-10-20 |
| RU2374252C2 (ru) | 2009-11-27 |
| IL180897A (en) | 2010-11-30 |
| JP5367265B2 (ja) | 2013-12-11 |
| ES2545260T3 (es) | 2015-09-09 |
| KR20070063504A (ko) | 2007-06-19 |
| JP2012236832A (ja) | 2012-12-06 |
| EP1797102B1 (de) | 2015-05-27 |
| MX2007001035A (es) | 2007-07-11 |
| KR101475635B1 (ko) | 2014-12-22 |
| KR20130028989A (ko) | 2013-03-20 |
| IL180897A0 (en) | 2007-07-04 |
| BRPI0513812B8 (pt) | 2021-07-27 |
| JP2008508266A (ja) | 2008-03-21 |
| EP1797102A1 (de) | 2007-06-20 |
| AU2005267668A1 (en) | 2006-02-02 |
| CN101035796A (zh) | 2007-09-12 |
| BRPI0513812B1 (pt) | 2017-05-09 |
| HK1107691A1 (en) | 2008-04-11 |
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