ZA200700101B - Prodrugs of HIV protease inhibitors - Google Patents

Prodrugs of HIV protease inhibitors

Info

Publication number
ZA200700101B
ZA200700101B ZA200700101A ZA200700101A ZA200700101B ZA 200700101 B ZA200700101 B ZA 200700101B ZA 200700101 A ZA200700101 A ZA 200700101A ZA 200700101 A ZA200700101 A ZA 200700101A ZA 200700101 B ZA200700101 B ZA 200700101B
Authority
ZA
South Africa
Prior art keywords
prodrugs
protease inhibitors
hiv protease
hiv
inhibitors
Prior art date
Application number
ZA200700101A
Other languages
English (en)
Inventor
David A Degoey
David J Grampovnik
Dale J Kempf
William J Flosi
Larry L Klein
Xiu C Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA200700101B publication Critical patent/ZA200700101B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200700101A 2004-07-06 2007-01-03 Prodrugs of HIV protease inhibitors ZA200700101B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58571004P 2004-07-06 2004-07-06

Publications (1)

Publication Number Publication Date
ZA200700101B true ZA200700101B (en) 2009-10-28

Family

ID=35063063

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700101A ZA200700101B (en) 2004-07-06 2007-01-03 Prodrugs of HIV protease inhibitors

Country Status (16)

Country Link
US (2) US7718633B2 (ja)
EP (2) EP2336138A3 (ja)
JP (2) JP5142714B2 (ja)
KR (1) KR101229431B1 (ja)
CN (1) CN101023090B (ja)
AU (1) AU2005270124B2 (ja)
BR (1) BRPI0512970A (ja)
CA (1) CA2571726C (ja)
ES (1) ES2402552T3 (ja)
HK (1) HK1104558A1 (ja)
IL (1) IL180433A (ja)
MX (1) MXPA06015108A (ja)
NZ (2) NZ590128A (ja)
TW (1) TWI365876B (ja)
WO (1) WO2006014282A2 (ja)
ZA (1) ZA200700101B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0512970A (pt) * 2004-07-06 2008-04-22 Abbott Lab prodrogas de inibidores da hiv protease
AP2985A (en) * 2006-07-07 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
ES2602784T3 (es) * 2007-02-23 2017-02-22 Gilead Sciences, Inc. Moduladores de las propiedades farmacocinéticas de los agentes terapéuticos
SI2003120T1 (sl) * 2007-06-12 2010-03-31 Concert Pharmaceuticals Inc Azapeptidni derivati kot inhibitorji hiv proteaze
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
KR101698028B1 (ko) 2008-05-20 2017-01-26 노이로제스엑스, 인코포레이티드 수용성 아세트아미노펜 유사체
KR101677126B1 (ko) 2008-05-20 2016-11-22 노이로제스엑스, 인코포레이티드 탄산염 프로드러그 및 그것의 사용 방법
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
EP2624869A4 (en) * 2010-10-08 2015-11-04 Univ Virginia Commonwealth PRODRUGS USING A CONTAINER CONTROLLED ABSORPTION MECHANISM
WO2012075117A2 (en) * 2010-12-01 2012-06-07 Ablitech, Inc. Small molecule-polymer conjugates and methods of making same
KR102537018B1 (ko) 2014-10-21 2023-05-30 애브비 인코포레이티드 카르비도파 및 l-도파 프로드럭 및 파킨슨병을 치료하기 위한 이들의 용도
EP4295909A2 (en) * 2016-04-20 2023-12-27 AbbVie Inc. Carbidopa and l-dopa prodrugs and methods of use
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TWI766172B (zh) 2018-07-30 2022-06-01 美商基利科學股份有限公司 抗hiv化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552558A (en) 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
CA2055685A1 (en) 1990-11-19 1992-05-20 Samuel L. Graham Hiv protease inhibitors having polyether substituents
MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
JPH09503497A (ja) * 1993-09-10 1997-04-08 ナルヘックス リミテッド 極性置換炭化水素
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US20030100088A1 (en) 2001-07-13 2003-05-29 Sigler Gerald F. Protease inhibitor conjugates and antibodies useful in immunoassay
US7205413B2 (en) * 2002-05-03 2007-04-17 Transform Pharmaceuticals, Inc. Solvates and polymorphs of ritonavir and methods of making and using the same
BRPI0512970A (pt) * 2004-07-06 2008-04-22 Abbott Lab prodrogas de inibidores da hiv protease

Also Published As

Publication number Publication date
CN101023090A (zh) 2007-08-22
EP1773850B1 (en) 2013-01-30
US7718633B2 (en) 2010-05-18
CA2571726A1 (en) 2006-02-09
US20100286032A1 (en) 2010-11-11
IL180433A0 (en) 2007-06-03
KR101229431B1 (ko) 2013-02-04
KR20070029244A (ko) 2007-03-13
EP1773850A2 (en) 2007-04-18
NZ590128A (en) 2012-08-31
JP2013040178A (ja) 2013-02-28
TW200613289A (en) 2006-05-01
AU2005270124A1 (en) 2006-02-09
AU2005270124B2 (en) 2011-09-08
EP2336138A2 (en) 2011-06-22
WO2006014282A2 (en) 2006-02-09
IL180433A (en) 2013-07-31
CA2571726C (en) 2013-05-21
EP2336138A3 (en) 2011-11-16
TWI365876B (en) 2012-06-11
ES2402552T3 (es) 2013-05-06
US8426388B2 (en) 2013-04-23
HK1104558A1 (en) 2008-01-18
WO2006014282A3 (en) 2006-05-11
CN101023090B (zh) 2013-03-27
NZ552276A (en) 2011-03-31
US20070270383A1 (en) 2007-11-22
JP5142714B2 (ja) 2013-02-13
BRPI0512970A (pt) 2008-04-22
MXPA06015108A (es) 2007-03-26
JP2008505898A (ja) 2008-02-28

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