ZA200610650B - Substituted triazoles as modulators of PPAR and methods of their preparation - Google Patents

Substituted triazoles as modulators of PPAR and methods of their preparation

Info

Publication number
ZA200610650B
ZA200610650B ZA200610650A ZA200610650A ZA200610650B ZA 200610650 B ZA200610650 B ZA 200610650B ZA 200610650 A ZA200610650 A ZA 200610650A ZA 200610650 A ZA200610650 A ZA 200610650A ZA 200610650 B ZA200610650 B ZA 200610650B
Authority
ZA
South Africa
Prior art keywords
ppar
modulators
preparation
methods
substituted triazoles
Prior art date
Application number
ZA200610650A
Other languages
English (en)
Inventor
Zhu Yan
Ma Jingyuan
Cheng Peng
Zhao Zuchun
Francine M Gregoire
Vera A Rakhmanova
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of ZA200610650B publication Critical patent/ZA200610650B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200610650A 2004-05-25 2005-05-24 Substituted triazoles as modulators of PPAR and methods of their preparation ZA200610650B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57442604P 2004-05-25 2004-05-25

Publications (1)

Publication Number Publication Date
ZA200610650B true ZA200610650B (en) 2009-04-29

Family

ID=35451382

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200610650A ZA200610650B (en) 2004-05-25 2005-05-24 Substituted triazoles as modulators of PPAR and methods of their preparation
ZA200801100A ZA200801100B (en) 2004-05-25 2008-02-01 Substituted triazoles as modulators of ppar and methods of their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA200801100A ZA200801100B (en) 2004-05-25 2008-02-01 Substituted triazoles as modulators of ppar and methods of their preparation

Country Status (13)

Country Link
US (2) US7323480B2 (xx)
EP (1) EP1751120A4 (xx)
JP (1) JP2008500357A (xx)
KR (1) KR20070036076A (xx)
CN (1) CN1997633A (xx)
AU (1) AU2005247473A1 (xx)
BR (1) BRPI0511510A (xx)
CA (1) CA2567437A1 (xx)
IL (1) IL179496A0 (xx)
MX (1) MXPA06013581A (xx)
RU (1) RU2006145872A (xx)
WO (1) WO2005115383A2 (xx)
ZA (2) ZA200610650B (xx)

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EA201270666A1 (ru) 2007-11-27 2012-12-28 Ардеа Биосайнсиз Инк. Соединения и фармацевтические композиции для снижения уровня мочевой кислоты
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WO2013033432A1 (en) * 2011-09-03 2013-03-07 Adipocyte Therapeutics Inc Methods and compositions for treating type 2 diabetes and related conditions
TWI551590B (zh) * 2012-01-18 2016-10-01 第一三共股份有限公司 經取代之苯吖唑衍生物
US20140178456A1 (en) * 2012-08-30 2014-06-26 Udaya Sankar Devanaboyina Methods and compositions for treating type 2 diabetes and related conditions
TW201418242A (zh) 2012-10-26 2014-05-16 Du Pont 作為除草劑之經取代的三唑
US10181018B2 (en) * 2013-03-14 2019-01-15 The University Of Toledo Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
CN103304504B (zh) * 2013-06-02 2015-03-04 张远强 一种抗糖尿病化合物、其制备方法和用途
CN103467398B (zh) * 2013-09-03 2015-01-21 浙江医药高等专科学校 三唑酰胺类化合物、其制备方法和其抗糖尿病用途
CA2923422C (en) 2013-09-09 2021-09-07 Vtv Therapeutics Llc Use of a ppar-delta agonist for treating muscle atrophy
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
WO2016057656A1 (en) * 2014-10-08 2016-04-14 Mitobridge, Inc. Ppar-delta agonists for use for treating mitochondrial, vascular, muscular, and demyelinating diseases
ES2643856B1 (es) * 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles para la regulación de la homeostasis de calcio intracelular
MX2019003949A (es) * 2016-10-05 2019-06-10 Mitobridge Inc Metodos para tratar lesion renal aguda.
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

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Also Published As

Publication number Publication date
AU2005247473A1 (en) 2005-12-08
CA2567437A1 (en) 2005-12-08
BRPI0511510A (pt) 2007-12-26
WO2005115383A3 (en) 2006-08-17
WO2005115383A2 (en) 2005-12-08
KR20070036076A (ko) 2007-04-02
ZA200801100B (en) 2008-09-25
IL179496A0 (en) 2007-05-15
US20080108630A1 (en) 2008-05-08
EP1751120A4 (en) 2010-05-05
MXPA06013581A (es) 2007-03-15
US20060014809A1 (en) 2006-01-19
RU2006145872A (ru) 2008-06-27
US7323480B2 (en) 2008-01-29
CN1997633A (zh) 2007-07-11
JP2008500357A (ja) 2008-01-10
EP1751120A2 (en) 2007-02-14

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