ZA200610043B - Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as CRF antagonists - Google Patents
Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as CRF antagonists Download PDFInfo
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- ZA200610043B ZA200610043B ZA200610043A ZA200610043A ZA200610043B ZA 200610043 B ZA200610043 B ZA 200610043B ZA 200610043 A ZA200610043 A ZA 200610043A ZA 200610043 A ZA200610043 A ZA 200610043A ZA 200610043 B ZA200610043 B ZA 200610043B
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- salkyl
- hydrogen
- hydroxy
- different
- same
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- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 title claims description 16
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical group C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 title claims description 14
- KDOPAZIWBAHVJB-UHFFFAOYSA-N 5h-pyrrolo[3,2-d]pyrimidine Chemical group C1=NC=C2NC=CC2=N1 KDOPAZIWBAHVJB-UHFFFAOYSA-N 0.000 title claims description 10
- 239000005557 antagonist Substances 0.000 title claims description 6
- -1 C.salkylthio Chemical group 0.000 claims description 247
- 229910052739 hydrogen Inorganic materials 0.000 claims description 106
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- 150000002367 halogens Chemical class 0.000 claims description 22
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- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001369 pituitary-adrenal system Anatomy 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 150000004944 pyrrolopyrimidines Chemical class 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2004188129 | 2004-06-25 |
Publications (1)
Publication Number | Publication Date |
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ZA200610043B true ZA200610043B (en) | 2008-06-25 |
Family
ID=34971524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200610043A ZA200610043B (en) | 2004-06-25 | 2005-06-24 | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as CRF antagonists |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070293670A1 (de) |
EP (1) | EP1781652A1 (de) |
JP (1) | JP2008503443A (de) |
KR (1) | KR20070024632A (de) |
CN (1) | CN1972941A (de) |
AU (1) | AU2005257486A1 (de) |
BR (1) | BRPI0512514A (de) |
CA (1) | CA2568802A1 (de) |
IL (1) | IL179605A0 (de) |
MX (1) | MXPA06015002A (de) |
NO (1) | NO20070467L (de) |
RU (1) | RU2007102683A (de) |
WO (1) | WO2006001501A1 (de) |
ZA (1) | ZA200610043B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1910185B (zh) * | 2004-01-06 | 2010-05-26 | 大正制药株式会社 | 吡咯并嘧啶和吡咯并三嗪衍生物作为crf受体拮抗剂 |
EP1701961A1 (de) | 2004-01-06 | 2006-09-20 | Taisho Pharmaceutical Co., Ltd | Mit einer cyclischen aminogruppe substituierte thienopyrimidin- und thienopyridinderivate |
ES2282986T3 (es) | 2004-01-06 | 2007-10-16 | Taisho Pharmaceutical Co., Ltd | Derivados de triaza-ciclopenta(cd)indeno. |
JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
DE102006042143A1 (de) * | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
DE102006056740A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
DE102006056739A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
US7738257B2 (en) * | 2006-12-13 | 2010-06-15 | Intel Corporation | Microelectronic device including bridging interconnect to top conductive layer of passive embedded structure and method of making same |
DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
DE102007061763A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
DE102007061764A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
ES2428818T3 (es) * | 2008-05-29 | 2013-11-11 | Bayer Intellectual Property Gmbh | Dicianopiridinas sustituidas con 2-alcoxi y su uso |
DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US1689161A (en) * | 1925-11-06 | 1928-10-23 | Charles A Skultin | Highway crossing |
US2941454A (en) * | 1957-10-21 | 1960-06-21 | Cedeno Arturo Olivero | Traffic intersection |
US3945745A (en) * | 1974-08-05 | 1976-03-23 | Chang Amos I T | Traffic flow control systems |
US6187781B1 (en) * | 1997-03-26 | 2001-02-13 | Taisho Pharmaceutical Co., Ltd. | 4-Tetrahydropyridylpyrimidine derivatives |
CA2366642A1 (en) * | 1999-03-11 | 2000-09-14 | Taisho Pharmaceutical Co., Ltd. | Carbamoyl tetrahydropyridine derivatives |
AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
US20020076276A1 (en) * | 2000-12-15 | 2002-06-20 | Troemel David Eric | Butzek-troemel roundabout or "spiralabout" |
ATE386727T1 (de) * | 2001-04-30 | 2008-03-15 | Glaxo Group Ltd | Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf) |
AR042667A1 (es) * | 2002-12-26 | 2005-06-29 | Taisho Pharmaceutical Co Ltd | Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico |
ES2282986T3 (es) * | 2004-01-06 | 2007-10-16 | Taisho Pharmaceutical Co., Ltd | Derivados de triaza-ciclopenta(cd)indeno. |
EP1701961A1 (de) * | 2004-01-06 | 2006-09-20 | Taisho Pharmaceutical Co., Ltd | Mit einer cyclischen aminogruppe substituierte thienopyrimidin- und thienopyridinderivate |
-
2005
- 2005-06-24 WO PCT/JP2005/012141 patent/WO2006001501A1/en active Application Filing
- 2005-06-24 AU AU2005257486A patent/AU2005257486A1/en not_active Abandoned
- 2005-06-24 EP EP05755651A patent/EP1781652A1/de not_active Withdrawn
- 2005-06-24 ZA ZA200610043A patent/ZA200610043B/en unknown
- 2005-06-24 BR BRPI0512514-6A patent/BRPI0512514A/pt not_active Application Discontinuation
- 2005-06-24 KR KR1020067027028A patent/KR20070024632A/ko not_active Application Discontinuation
- 2005-06-24 RU RU2007102683/04A patent/RU2007102683A/ru not_active Application Discontinuation
- 2005-06-24 MX MXPA06015002A patent/MXPA06015002A/es unknown
- 2005-06-24 CN CNA2005800209637A patent/CN1972941A/zh active Pending
- 2005-06-24 US US11/630,041 patent/US20070293670A1/en not_active Abandoned
- 2005-06-24 CA CA002568802A patent/CA2568802A1/en not_active Abandoned
- 2005-06-24 JP JP2006549731A patent/JP2008503443A/ja not_active Abandoned
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2006
- 2006-11-27 IL IL179605A patent/IL179605A0/en unknown
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2007
- 2007-01-24 NO NO20070467A patent/NO20070467L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1972941A (zh) | 2007-05-30 |
EP1781652A1 (de) | 2007-05-09 |
NO20070467L (no) | 2007-01-24 |
MXPA06015002A (es) | 2007-02-08 |
KR20070024632A (ko) | 2007-03-02 |
WO2006001501A1 (en) | 2006-01-05 |
RU2007102683A (ru) | 2008-07-27 |
AU2005257486A1 (en) | 2006-01-05 |
US20070293670A1 (en) | 2007-12-20 |
IL179605A0 (en) | 2007-05-15 |
JP2008503443A (ja) | 2008-02-07 |
CA2568802A1 (en) | 2006-01-05 |
BRPI0512514A (pt) | 2008-03-11 |
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