ZA200608875B - Prolinyl derivatives for treating thrombosis - Google Patents
Prolinyl derivatives for treating thrombosis Download PDFInfo
- Publication number
- ZA200608875B ZA200608875B ZA200608875A ZA200608875A ZA200608875B ZA 200608875 B ZA200608875 B ZA 200608875B ZA 200608875 A ZA200608875 A ZA 200608875A ZA 200608875 A ZA200608875 A ZA 200608875A ZA 200608875 B ZA200608875 B ZA 200608875B
- Authority
- ZA
- South Africa
- Prior art keywords
- denotes
- formula
- salts
- phenyl
- hydroxypyrrolidine
- Prior art date
Links
- 208000007536 Thrombosis Diseases 0.000 title claims description 12
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- 150000001875 compounds Chemical class 0.000 claims description 93
- 150000003839 salts Chemical class 0.000 claims description 59
- -1 4-ethynylphenyl Chemical group 0.000 claims description 36
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- 239000004480 active ingredient Substances 0.000 claims description 11
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004014945A DE102004014945A1 (de) | 2004-03-26 | 2004-03-26 | Prolinylderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200608875B true ZA200608875B (en) | 2008-06-25 |
Family
ID=34961159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200608875A ZA200608875B (en) | 2004-03-26 | 2006-10-25 | Prolinyl derivatives for treating thrombosis |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7683093B2 (fr) |
| EP (1) | EP1735279A1 (fr) |
| JP (1) | JP2007530469A (fr) |
| KR (1) | KR20070010131A (fr) |
| CN (1) | CN1938269A (fr) |
| AR (1) | AR048326A1 (fr) |
| AU (1) | AU2005225489B2 (fr) |
| BR (1) | BRPI0509174A (fr) |
| CA (1) | CA2561057A1 (fr) |
| DE (1) | DE102004014945A1 (fr) |
| MX (1) | MXPA06010771A (fr) |
| RU (1) | RU2006137656A (fr) |
| WO (1) | WO2005092849A1 (fr) |
| ZA (1) | ZA200608875B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5015593B2 (ja) * | 2003-06-18 | 2012-08-29 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血栓症の治療のための凝固因子ＸａおよびＶＩＩａの阻害剤としての１−［（４−エチニルフェニル）］−２−［（フェニル）］−ピロリジン−１，２−ジカルボキサミド誘導体 |
| DE10358814A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
| EP1818330A1 (fr) | 2006-02-14 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co.KG | Proline-amides substituées, leurs préparation et leurs utilisation comme médicament |
| KR101422456B1 (ko) | 2006-05-16 | 2014-07-23 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 프롤린아미드, 이의 제조방법 및 약물로서의 이의 용도 |
| WO2009000878A1 (fr) * | 2007-06-28 | 2008-12-31 | Novartis Ag | Modulateurs de la kallikréine 7 |
| ES2905401T3 (es) * | 2015-10-01 | 2022-04-08 | Biocryst Pharm Inc | Inhibidores de calicreína plasmática humana |
| CN110240591A (zh) * | 2018-03-08 | 2019-09-17 | 天津药物研究院有限公司 | 脯氨酸衍生物及其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064682C (zh) * | 1995-07-31 | 2001-04-18 | 盐野义制药株式会社 | 具有磷脂酶a2抑制活性的吡咯烷衍生物 |
| US6673817B1 (en) * | 1999-05-24 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| JP2003500390A (ja) * | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| US7312235B2 (en) * | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
-
2004
- 2004-03-26 DE DE102004014945A patent/DE102004014945A1/de not_active Withdrawn
-
2005
- 2005-03-04 KR KR1020067019772A patent/KR20070010131A/ko not_active Application Discontinuation
- 2005-03-04 JP JP2007504284A patent/JP2007530469A/ja active Pending
- 2005-03-04 BR BRPI0509174-8A patent/BRPI0509174A/pt not_active Application Discontinuation
- 2005-03-04 AU AU2005225489A patent/AU2005225489B2/en not_active Ceased
- 2005-03-04 US US10/594,024 patent/US7683093B2/en not_active Expired - Fee Related
- 2005-03-04 CN CNA200580009735XA patent/CN1938269A/zh active Pending
- 2005-03-04 EP EP05715737A patent/EP1735279A1/fr not_active Withdrawn
- 2005-03-04 MX MXPA06010771A patent/MXPA06010771A/es not_active Application Discontinuation
- 2005-03-04 WO PCT/EP2005/002306 patent/WO2005092849A1/fr active Application Filing
- 2005-03-04 CA CA002561057A patent/CA2561057A1/fr not_active Abandoned
- 2005-03-04 RU RU2006137656/04A patent/RU2006137656A/ru unknown
- 2005-03-23 AR ARP050101135A patent/AR048326A1/es unknown
-
2006
- 2006-10-25 ZA ZA200608875A patent/ZA200608875B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2561057A1 (fr) | 2005-10-06 |
| KR20070010131A (ko) | 2007-01-22 |
| MXPA06010771A (es) | 2006-12-15 |
| WO2005092849A1 (fr) | 2005-10-06 |
| AR048326A1 (es) | 2006-04-19 |
| US7683093B2 (en) | 2010-03-23 |
| BRPI0509174A (pt) | 2007-09-18 |
| CN1938269A (zh) | 2007-03-28 |
| DE102004014945A1 (de) | 2005-10-13 |
| AU2005225489B2 (en) | 2011-02-10 |
| JP2007530469A (ja) | 2007-11-01 |
| RU2006137656A (ru) | 2008-05-10 |
| EP1735279A1 (fr) | 2006-12-27 |
| US20070135507A1 (en) | 2007-06-14 |
| AU2005225489A1 (en) | 2005-10-06 |
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