ZA200608832B - Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof - Google Patents
Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof Download PDFInfo
- Publication number
- ZA200608832B ZA200608832B ZA200608832A ZA200608832A ZA200608832B ZA 200608832 B ZA200608832 B ZA 200608832B ZA 200608832 A ZA200608832 A ZA 200608832A ZA 200608832 A ZA200608832 A ZA 200608832A ZA 200608832 B ZA200608832 B ZA 200608832B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkylene
- hydrogen
- replaced
- phenyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 95
- 239000003814 drug Substances 0.000 title claims description 14
- 150000003217 pyrazoles Chemical class 0.000 title description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 49
- 239000001257 hydrogen Substances 0.000 claims description 44
- 229910052731 fluorine Inorganic materials 0.000 claims description 35
- 229910052760 oxygen Inorganic materials 0.000 claims description 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 22
- -1 COO-(C1-Cg)-alkyl Chemical group 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 20
- 239000011737 fluorine Substances 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- 150000002431 hydrogen Chemical class 0.000 claims description 16
- 229910052794 bromium Inorganic materials 0.000 claims description 15
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 14
- 229910052801 chlorine Inorganic materials 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 13
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 11
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 11
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- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 9
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- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 8
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- 229910052740 iodine Inorganic materials 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 229910006069 SO3H Inorganic materials 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 6
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- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
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- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
- 229910006074 SO2NH2 Inorganic materials 0.000 claims description 4
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- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims description 3
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- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims description 2
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Landscapes
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004028241A DE102004028241B4 (de) | 2004-06-11 | 2004-06-11 | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
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|---|---|
| ZA200608832B true ZA200608832B (en) | 2008-05-28 |
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| ZA200608832A ZA200608832B (en) | 2004-06-11 | 2006-10-24 | Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof |
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| EP (1) | EP1758914B1 (ru) |
| JP (1) | JP4996464B2 (ru) |
| CN (1) | CN100582116C (ru) |
| AR (1) | AR049393A1 (ru) |
| AU (1) | AU2005252329B2 (ru) |
| BR (1) | BRPI0510770A (ru) |
| CA (1) | CA2570042C (ru) |
| CR (1) | CR8773A (ru) |
| CY (1) | CY1107426T1 (ru) |
| DE (2) | DE102004028241B4 (ru) |
| DK (1) | DK1758914T3 (ru) |
| EC (1) | ECSP067054A (ru) |
| ES (1) | ES2296180T3 (ru) |
| HK (1) | HK1100411A1 (ru) |
| HR (1) | HRP20080023T3 (ru) |
| IL (1) | IL179757A (ru) |
| MA (1) | MA28653B1 (ru) |
| MX (1) | MXPA06013513A (ru) |
| MY (1) | MY143565A (ru) |
| NO (1) | NO20070176L (ru) |
| NZ (1) | NZ551948A (ru) |
| PE (1) | PE20060297A1 (ru) |
| PL (1) | PL1758914T3 (ru) |
| PT (1) | PT1758914E (ru) |
| RS (1) | RS50541B (ru) |
| RU (1) | RU2370499C2 (ru) |
| SI (1) | SI1758914T1 (ru) |
| TN (1) | TNSN06409A1 (ru) |
| TW (1) | TWI382030B (ru) |
| UA (1) | UA89787C2 (ru) |
| UY (1) | UY28955A1 (ru) |
| WO (1) | WO2005121161A1 (ru) |
| ZA (1) | ZA200608832B (ru) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| WO2007136116A2 (en) | 2006-05-19 | 2007-11-29 | Taisho Pharmaceutical Co., Ltd. | C-phenyl glycitol compound for the treatment of diabetes |
| CA2655937A1 (en) * | 2006-06-29 | 2008-01-03 | Taisho Pharmaceutical Co., Ltd. | C-phenyl 1-thioglucitol compound |
| WO2008017381A1 (de) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE102006053637B4 (de) | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP2103607A4 (en) | 2006-12-14 | 2011-01-05 | Taisho Pharmaceutical Co Ltd | 1-phenyl-1-thio-D-GLUCITOLDERIVAT |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5272395B2 (ja) * | 2007-12-12 | 2013-08-28 | セントラル硝子株式会社 | ４−デオキシ−４−フルオロ−ｄ−グルコース誘導体の製造方法 |
| EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| CN102149717B (zh) * | 2008-08-28 | 2014-05-14 | 辉瑞大药厂 | 二氧杂-双环[3.2.1]辛烷-2，3，4-三醇衍生物 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| EP2398786B1 (en) | 2009-02-23 | 2012-12-12 | Taisho Pharmaceutical Co., Ltd. | 4 -isopropylphenyl glucitol compounds as sglt1 inhibitors |
| EP2470552B1 (en) * | 2009-08-26 | 2013-11-13 | Sanofi | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2298782A1 (en) | 2009-08-26 | 2011-03-23 | Sanofi-Aventis | Method for producing pyrazole glycoside derivatives |
| US20120270819A1 (en) * | 2009-10-02 | 2012-10-25 | Sanofi | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone disease |
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| TW406086B (en) * | 1996-12-26 | 2000-09-21 | Tanabe Seiyaku Co | Propiophenone derivatives and process for preparing the same |
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| JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
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| US20060035844A1 (en) * | 2002-12-04 | 2006-02-16 | Fumiaki Ito | Preventive or remedy for diseases caused by hyperglycemia |
| DE10258008B4 (de) * | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
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