ZA200604025B - Phosphodiesterase V inhibitor formulations - Google Patents
Phosphodiesterase V inhibitor formulations Download PDFInfo
- Publication number
- ZA200604025B ZA200604025B ZA200604025A ZA200604025A ZA200604025B ZA 200604025 B ZA200604025 B ZA 200604025B ZA 200604025 A ZA200604025 A ZA 200604025A ZA 200604025 A ZA200604025 A ZA 200604025A ZA 200604025 B ZA200604025 B ZA 200604025B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- composition according
- substituents
- alkyl
- povidone
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 59
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title description 18
- 238000009472 formulation Methods 0.000 title description 6
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- 239000006185 dispersion Substances 0.000 claims description 35
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Classifications
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/18—Processes for applying liquids or other fluent materials performed by dipping
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/14—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2202/00—Metallic substrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2258/00—Small objects (e.g. screws)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52473103P | 2003-11-21 | 2003-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200604025B true ZA200604025B (en) | 2008-01-30 |
Family
ID=34632926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200604025A ZA200604025B (en) | 2003-11-21 | 2006-05-18 | Phosphodiesterase V inhibitor formulations |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060040962A1 (es) |
| EP (1) | EP1691788A2 (es) |
| JP (1) | JP2007512345A (es) |
| KR (1) | KR20060101762A (es) |
| CN (1) | CN1905860A (es) |
| AR (1) | AR047948A1 (es) |
| AU (1) | AU2004292991A1 (es) |
| BR (1) | BRPI0416202A (es) |
| CA (1) | CA2546248A1 (es) |
| MX (1) | MXPA06005681A (es) |
| NO (1) | NO20062883L (es) |
| PE (1) | PE20050985A1 (es) |
| TW (1) | TW200526664A (es) |
| WO (1) | WO2005051368A2 (es) |
| ZA (1) | ZA200604025B (es) |
Families Citing this family (5)
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|---|---|---|---|---|
| MX2008000087A (es) * | 2005-06-23 | 2008-03-18 | Schering Corp | Formulaciones orales rapidamente absorbentes de inhibidores de la fosfodiesterasa 5. |
| CA2660086C (en) * | 2006-08-16 | 2014-09-16 | Novartis Ag | Method of making solid dispersions of highly crystalline therapeutic compounds |
| MX2010005198A (es) * | 2007-11-12 | 2010-05-20 | Novartis Ag | Composiciones liquidas que comprenden valsartan. |
| ITMI20080227A1 (it) * | 2008-02-13 | 2009-08-14 | Felice Vinati | '' dispositivo di sicurezza per apparati di sollevamento a fune '' |
| JP6002562B2 (ja) * | 2012-12-05 | 2016-10-05 | 横浜ゴム株式会社 | 面ファスナー付き空気入りタイヤ及びその製造方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057628A (en) * | 1976-04-19 | 1977-11-08 | William L. Wilson | Removal of hepatitis associated antigen from plasma |
| US4902514A (en) * | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| IL98559A0 (en) * | 1990-06-21 | 1992-07-15 | Schering Corp | Polycyclic guanine derivatives |
| CA2098846A1 (en) * | 1990-12-21 | 1992-06-22 | David G. Smith | Xanthine derivatives |
| WO1994019351A1 (en) * | 1993-02-26 | 1994-09-01 | Schering Corporation | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
| US5470479A (en) * | 1994-06-23 | 1995-11-28 | Westinghouse Electric Corporation | Continuous, steady-state, chromatographic separation of gadolinium isotopes |
| UA46166C2 (uk) * | 1997-11-12 | 2002-05-15 | Баєр Акцієнгезельшафт | 2-фенілзаміщені імідазотриазинони як інгібітори фосфодіестерази, спосіб їх одержання та лікарський засіб на їх основі |
| US20030153623A1 (en) * | 1998-07-22 | 2003-08-14 | Yamanouchi Pharmaceutical Co., Ltd. | Solid preparation containing sparingly soluble NSAIDs |
| JP3290970B2 (ja) * | 1998-07-22 | 2002-06-10 | 山之内製薬株式会社 | 難溶性ＮＳＡＩＤｓ含有固形製剤 |
| US6025362A (en) * | 1998-08-31 | 2000-02-15 | Fukunaga; Atsuo F. | Uses of xanthine compounds |
| ATE400252T1 (de) * | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
| US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| JP5767429B2 (ja) * | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | 固体分散剤中の結晶化阻害剤 |
| US6491950B1 (en) * | 2000-08-07 | 2002-12-10 | Kos Pharmaceuticals, Inc. | Controlled release pharmaceutical composition |
| JP3470096B2 (ja) * | 2000-09-19 | 2003-11-25 | 沢井製薬株式会社 | ニルバジピン含有易溶性固形製剤およびその製造法 |
| US6821978B2 (en) * | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| EP1421084B1 (en) * | 2001-08-28 | 2008-05-14 | Schering Corporation | Polycyclic guanine phosphodiesterase v inhibitors |
| CA2465893A1 (en) * | 2001-11-09 | 2003-05-22 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
| AU2002360775B9 (en) * | 2001-12-28 | 2008-07-24 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof |
| WO2003101991A1 (en) * | 2002-05-31 | 2003-12-11 | Schering Corporation | Xanthine phosphodiesterase v inhibitor polymorphs |
| JP2005529934A (ja) * | 2002-05-31 | 2005-10-06 | シェーリング コーポレイション | キサンチンホスホジエステラーゼｖインヒビターおよびその前駆物質を調製するプロセス |
| US7659305B2 (en) * | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
-
2004
- 2004-11-18 AR ARP040104262A patent/AR047948A1/es not_active Application Discontinuation
- 2004-11-18 MX MXPA06005681A patent/MXPA06005681A/es active IP Right Grant
- 2004-11-18 BR BRPI0416202-1A patent/BRPI0416202A/pt not_active IP Right Cessation
- 2004-11-18 CN CNA200480040545XA patent/CN1905860A/zh active Pending
- 2004-11-18 CA CA002546248A patent/CA2546248A1/en not_active Abandoned
- 2004-11-18 JP JP2006541424A patent/JP2007512345A/ja active Pending
- 2004-11-18 TW TW093135475A patent/TW200526664A/zh unknown
- 2004-11-18 PE PE2004001130A patent/PE20050985A1/es not_active Application Discontinuation
- 2004-11-18 EP EP04811583A patent/EP1691788A2/en not_active Ceased
- 2004-11-18 WO PCT/US2004/038887 patent/WO2005051368A2/en active Application Filing
- 2004-11-18 KR KR1020067009586A patent/KR20060101762A/ko not_active Application Discontinuation
- 2004-11-18 AU AU2004292991A patent/AU2004292991A1/en not_active Abandoned
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2006
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2008
- 2008-11-18 US US12/272,913 patent/US20090074869A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0416202A (pt) | 2006-12-26 |
| WO2005051368A2 (en) | 2005-06-09 |
| WO2005051368A3 (en) | 2006-03-09 |
| TW200526664A (en) | 2005-08-16 |
| CA2546248A1 (en) | 2005-06-09 |
| JP2007512345A (ja) | 2007-05-17 |
| PE20050985A1 (es) | 2005-11-26 |
| CN1905860A (zh) | 2007-01-31 |
| NO20062883L (no) | 2006-08-18 |
| MXPA06005681A (es) | 2006-08-17 |
| AR047948A1 (es) | 2006-03-15 |
| US20090074869A1 (en) | 2009-03-19 |
| EP1691788A2 (en) | 2006-08-23 |
| AU2004292991A1 (en) | 2005-06-09 |
| KR20060101762A (ko) | 2006-09-26 |
| US20060040962A1 (en) | 2006-02-23 |
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