ZA200603594B - Bicyclic pyrazolyl and imidazolyl compounds and uses thereof - Google Patents
Bicyclic pyrazolyl and imidazolyl compounds and uses thereof Download PDFInfo
- Publication number
- ZA200603594B ZA200603594B ZA200603594A ZA200603594A ZA200603594B ZA 200603594 B ZA200603594 B ZA 200603594B ZA 200603594 A ZA200603594 A ZA 200603594A ZA 200603594 A ZA200603594 A ZA 200603594A ZA 200603594 B ZA200603594 B ZA 200603594B
- Authority
- ZA
- South Africa
- Prior art keywords
- chlorophenyl
- compound
- alkyl
- azulen
- triaza
- Prior art date
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- 125000002883 imidazolyl group Chemical group 0.000 title description 2
- -1 arvi Chemical group 0.000 claims description 74
- 150000001875 compounds Chemical class 0.000 claims description 70
- 125000001424 substituent group Chemical group 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000003118 aryl group Chemical group 0.000 claims description 39
- 125000000623 heterocyclic group Chemical group 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 33
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
- 125000001072 heteroaryl group Chemical group 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 239000012453 solvate Substances 0.000 claims description 18
- 239000000126 substance Chemical group 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- 125000002837 carbocyclic group Chemical group 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 239000005557 antagonist Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
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- 125000002252 acyl group Chemical group 0.000 claims description 10
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- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
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- 125000005843 halogen group Chemical group 0.000 claims description 6
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- NMDXWGLMBYRKCQ-UHFFFAOYSA-N 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2,2-trifluoroethyl)-5,6-dihydro-4h-pyrazolo[4,3-e][1,4]diazepin-8-one Chemical compound O=C1N(CC(F)(F)F)CCNC=2C1=NN(C=1C(=CC=CC=1)Cl)C=2C1=CC=C(Cl)C=C1 NMDXWGLMBYRKCQ-UHFFFAOYSA-N 0.000 claims 1
- LRZXYARISQFUKT-UHFFFAOYSA-N 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluorobutyl)-5,6-dihydropyrazolo[3,4-f][1,4]oxazepin-8-one Chemical compound O=C1N(CC(F)(F)CC)CCOC=2C1=NN(C=1C(=CC=CC=1)Cl)C=2C1=CC=C(Cl)C=C1 LRZXYARISQFUKT-UHFFFAOYSA-N 0.000 claims 1
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Landscapes
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51828003P | 2003-11-07 | 2003-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200603594B true ZA200603594B (en) | 2007-09-26 |
Family
ID=34572986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200603594A ZA200603594B (en) | 2003-11-07 | 2006-05-05 | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
Country Status (29)
| Country | Link |
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| US (2) | US7151097B2 (ja) |
| EP (1) | EP1682554A1 (ja) |
| JP (2) | JP4056549B2 (ja) |
| KR (1) | KR20060086396A (ja) |
| CN (1) | CN1886407A (ja) |
| AP (1) | AP2006003601A0 (ja) |
| AR (1) | AR046831A1 (ja) |
| AU (1) | AU2004286909A1 (ja) |
| BR (1) | BRPI0416299A (ja) |
| CA (1) | CA2544752A1 (ja) |
| CR (1) | CR8387A (ja) |
| DO (1) | DOP2004001024A (ja) |
| EA (1) | EA009742B1 (ja) |
| EC (1) | ECSP066549A (ja) |
| GT (1) | GT200400226A (ja) |
| HR (1) | HRP20060166A2 (ja) |
| IL (1) | IL175283A0 (ja) |
| IS (1) | IS8426A (ja) |
| MA (1) | MA28151A1 (ja) |
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| DE10138275A1 (de) * | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Verbindungen zur Beseitigung der Anhedonie |
| EP1603585A2 (en) * | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| ITMI20041032A1 (it) * | 2004-05-24 | 2004-08-24 | Neuroscienze S C A R L | Compositi farmaceutici |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
| AU2005288671A1 (en) * | 2004-09-27 | 2006-04-06 | Pfizer Products Inc. | Process for preparing bicyclic pyrazolyl compounds |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| WO2006111849A1 (en) * | 2005-04-20 | 2006-10-26 | Pfizer Products Inc. | Acylaminobicyclic heteromatic compounds as cannabinoid receptor ligands |
| CA2609783A1 (en) * | 2005-05-27 | 2006-12-07 | Pfizer Products Inc. | Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| US7872006B2 (en) | 2005-10-21 | 2011-01-18 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (CB1) antagonizing activity |
| WO2007060525A2 (en) | 2005-11-28 | 2007-05-31 | Pfizer Products Inc. | Process for preparing bicyclic pyrazolyl and imidazolyl compounds |
| MEP6808A (xx) * | 2006-02-23 | 2010-02-10 | Lundbeck & Co As H | Priperidinoilpirodolini agonisti receptora menalokortina tipa 4 |
| EP2742936A1 (en) * | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| WO2008048648A2 (en) * | 2006-10-17 | 2008-04-24 | Acadia Pharmaceuticals Inc. | Cb1-modulating compounds and their use |
| CN101583593A (zh) | 2006-11-13 | 2009-11-18 | 辉瑞产品公司 | 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途 |
| WO2009032754A2 (en) * | 2007-08-31 | 2009-03-12 | Kalypsys, Inc. | Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| ES2421920T3 (es) * | 2008-08-06 | 2013-09-06 | Pfizer Ltd | Compuestos de diazepina y diazocano como agonistas de MC4 |
| US9549006B2 (en) * | 2013-07-31 | 2017-01-17 | Cisco Technology, Inc. | Self-adaptive sample period for content sharing in communication sessions |
| PL3066085T3 (pl) * | 2013-11-08 | 2020-11-02 | Incyte Holdings Corporation | Sposób syntezy inhibitora 2,3-dioksygenazy indoloaminowej |
| US11504416B2 (en) | 2018-09-04 | 2022-11-22 | Paw Power, Inc. | Formulation with cannabinoids |
| WO2020060761A2 (en) | 2018-09-04 | 2020-03-26 | Skodda Anja | Pet food formulation with cannabinoids |
| EP4011204A4 (en) | 2019-08-09 | 2023-08-23 | Nihon Nohyaku Co., Ltd. | OXEPINONE DERIVATIVE, INSECTICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING SUCH DERIVATIVE, AND METHOD OF USE |
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| AU2001234958A1 (en) | 2000-02-11 | 2001-08-20 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| JP2005507875A (ja) | 2001-08-31 | 2005-03-24 | ユニバーシティ オブ コネチカット | カンナビノイド受容体に作用する新規なピラゾール類似体 |
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| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7423031B2 (en) | 2003-05-01 | 2008-09-09 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP1622876A1 (en) | 2003-05-07 | 2006-02-08 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
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| US20050026983A1 (en) | 2003-07-30 | 2005-02-03 | Pfizer Inc | Imidazole compounds and uses thereof |
| US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| AU2005288671A1 (en) * | 2004-09-27 | 2006-04-06 | Pfizer Products Inc. | Process for preparing bicyclic pyrazolyl compounds |
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- 2004-10-25 WO PCT/IB2004/003522 patent/WO2005044822A1/en active Application Filing
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- 2004-10-25 AU AU2004286909A patent/AU2004286909A1/en not_active Abandoned
- 2004-10-25 AP AP2006003601A patent/AP2006003601A0/xx unknown
- 2004-10-25 JP JP2006538974A patent/JP4056549B2/ja not_active Expired - Fee Related
- 2004-10-25 EP EP04769741A patent/EP1682554A1/en not_active Withdrawn
- 2004-10-25 OA OA1200600145A patent/OA13280A/en unknown
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- 2004-10-25 EA EA200600647A patent/EA009742B1/ru not_active IP Right Cessation
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- 2004-11-02 TW TW093133372A patent/TWI280245B/zh not_active IP Right Cessation
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- 2004-11-04 PE PE2004001074A patent/PE20050576A1/es not_active Application Discontinuation
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- 2004-11-05 AR ARP040104075A patent/AR046831A1/es not_active Application Discontinuation
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- 2006-05-04 HR HR20060166A patent/HRP20060166A2/xx not_active Application Discontinuation
- 2006-05-05 EC EC2006006549A patent/ECSP066549A/es unknown
- 2006-05-05 TN TNP2006000129A patent/TNSN06129A1/fr unknown
- 2006-05-05 CR CR8387A patent/CR8387A/es not_active Application Discontinuation
- 2006-05-05 MA MA29005A patent/MA28151A1/fr unknown
- 2006-05-05 ZA ZA200603594A patent/ZA200603594B/en unknown
- 2006-06-07 NO NO20062618A patent/NO20062618L/no not_active Application Discontinuation
- 2006-09-07 US US11/470,695 patent/US20070027133A1/en not_active Abandoned
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