ZA200603419B - Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof - Google Patents
Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof Download PDFInfo
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- ZA200603419B ZA200603419B ZA200603419A ZA200603419A ZA200603419B ZA 200603419 B ZA200603419 B ZA 200603419B ZA 200603419 A ZA200603419 A ZA 200603419A ZA 200603419 A ZA200603419 A ZA 200603419A ZA 200603419 B ZA200603419 B ZA 200603419B
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- South Africa
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- compound according
- solvate
- hydrate
- acceptable salt
- pharmaceutically acceptable
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- 238000011282 treatment Methods 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 19
- 230000002503 metabolic effect Effects 0.000 title claims description 14
- 150000003536 tetrazoles Chemical class 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 88
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 47
- 150000003839 salts Chemical class 0.000 claims description 34
- 239000012453 solvate Substances 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 229910052736 halogen Inorganic materials 0.000 claims description 27
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 27
- 125000001188 haloalkyl group Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 20
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- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 14
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- LTQYSJKGRPGMPO-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Chemical compound C1=2CCCC=2NN=C1C1=NN=NN1 LTQYSJKGRPGMPO-UHFFFAOYSA-N 0.000 claims 1
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- SWSJDJYGSQGAFF-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-1,6-dihydrocyclopenta[c]pyrazole Chemical compound C1C=CC2=C1NN=C2C1=NN=NN1 SWSJDJYGSQGAFF-UHFFFAOYSA-N 0.000 claims 1
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- CXBPIKBDSFXEMF-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-4,6-dihydro-1h-thieno[3,4-c]pyrazole Chemical compound C1SCC=2C1=NNC=2C1=NN=NN1 CXBPIKBDSFXEMF-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP1603585A2 (en) | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| TWI258478B (en) | 2003-10-31 | 2006-07-21 | Arena Pharm Inc | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
| ES2331521T3 (es) * | 2003-11-21 | 2010-01-07 | Arena Pharmaceuticals, Inc. | Derivados de acido 4-oxo-4,5-dihidro-furan-2-carboxilico y procedimientos de tratamiento de trastornos metabolicos relacionados del mismo. |
| WO2006026273A2 (en) * | 2004-08-25 | 2006-03-09 | Merck & Co., Inc. | Method of treating atherosclerosis, dyslipidemias and related conditions |
| CN101076331A (zh) * | 2004-11-05 | 2007-11-21 | 艾尼纳制药公司 | 包含烟酸受体部分促效剂的用于治疗发红和脂质相关病症的组合物 |
| PE20060949A1 (es) | 2004-12-23 | 2006-10-11 | Arena Pharm Inc | Derivados fusionados de pirazol como agonistas del receptor de niacina |
| US8168799B2 (en) | 2005-04-28 | 2012-05-01 | Merck Sharpe & Dohme Ltd. | Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles |
| PT1901731E (pt) | 2005-06-28 | 2011-05-11 | Merck Sharp & Dohme | Agonistas de receptor de niacina, composi??es que cont?m tais compostos e m?todos de tratamento |
| DE102006021733A1 (de) * | 2006-05-09 | 2007-11-22 | Bayer Healthcare Ag | 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung |
| DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| HK1210825A1 (en) | 2012-07-11 | 2016-05-06 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
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