ZA200601595B - Aminopyrones and their use as ATM inhibitors - Google Patents
Aminopyrones and their use as ATM inhibitorsInfo
- Publication number
- ZA200601595B ZA200601595B ZA200601595A ZA200601595A ZA200601595B ZA 200601595 B ZA200601595 B ZA 200601595B ZA 200601595 A ZA200601595 A ZA 200601595A ZA 200601595 A ZA200601595 A ZA 200601595A ZA 200601595 B ZA200601595 B ZA 200601595B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- optionally substituted
- aminopyrones
- atm inhibitors
- prodrugs
- Prior art date
Links
- AJJKPRWJTNUWLU-UHFFFAOYSA-N 3-aminopyran-2-one Chemical class NC1=CC=COC1=O AJJKPRWJTNUWLU-UHFFFAOYSA-N 0.000 title 1
- 239000012827 ATM inhibitor Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49477603P | 2003-08-13 | 2003-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200601595B true ZA200601595B (en) | 2007-03-28 |
Family
ID=34193236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200601595A ZA200601595B (en) | 2003-08-13 | 2006-02-23 | Aminopyrones and their use as ATM inhibitors |
Country Status (19)
Country | Link |
---|---|
US (2) | US7429660B2 (de) |
EP (1) | EP1654257B1 (de) |
JP (1) | JP2007501836A (de) |
KR (1) | KR20060066722A (de) |
CN (1) | CN1867566B (de) |
AT (1) | ATE461193T1 (de) |
AU (1) | AU2004265149A1 (de) |
BR (1) | BRPI0413467A (de) |
CA (1) | CA2534300A1 (de) |
DE (1) | DE602004026071D1 (de) |
ES (1) | ES2341342T3 (de) |
GB (1) | GB2420781B (de) |
HK (1) | HK1097273A1 (de) |
MX (1) | MXPA06001599A (de) |
NO (1) | NO20061126L (de) |
NZ (1) | NZ545919A (de) |
TW (1) | TW200524924A (de) |
WO (1) | WO2005016919A1 (de) |
ZA (1) | ZA200601595B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
DE602004026071D1 (de) * | 2003-08-13 | 2010-04-29 | Kudos Pharm Ltd | Aminopyrone und ihre verwendung als atm inhibitoren |
UA88329C2 (en) | 2004-09-20 | 2009-10-12 | Кудос Фармасьютикалз Лимитед | Dna-pk inhibitors |
JP2008529995A (ja) * | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Atm阻害剤 |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
US20070049588A1 (en) * | 2005-08-31 | 2007-03-01 | Kudos Pharmaceuticals Limited | Atm inhibitor |
EP1976566A4 (de) | 2005-12-19 | 2010-10-20 | Univ Northwestern | Zusammensetzungen und verfahren zur verwendung der rnai |
US20080279866A1 (en) * | 2006-08-25 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Induction of immunosuppression by inhibition of ATM |
CA2674378A1 (en) | 2007-01-03 | 2008-07-17 | Burnham Institute For Medical Research | Methods and compositions related to clot binding compounds |
WO2008080398A1 (en) * | 2007-01-05 | 2008-07-10 | Bkg Pharma Aps | Anti - infective agents such as phenothiazine and thioxanthene derivates to treat infectious diseases |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
EP2512497A1 (de) | 2009-12-18 | 2012-10-24 | Sanford-Burnham Medical Research Institute | Verfahren und zusammensetzungen im zusammenhang mit gerinnselbindenden verbndungen |
KR20140147797A (ko) | 2011-06-27 | 2014-12-30 | 더 잭슨 래보라토리 | 암 및 자가면역 질환의 치료 방법 및 조성물 |
WO2013043744A2 (en) | 2011-09-21 | 2013-03-28 | Inception 1, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
EP3042900B1 (de) * | 2013-08-29 | 2020-09-23 | Fujifilm Corporation | Neuartige morpholinderivate oder salz davon |
KR20160049435A (ko) | 2014-10-27 | 2016-05-09 | 삼성전자주식회사 | Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
WO2018153365A1 (zh) * | 2017-02-27 | 2018-08-30 | 上海瑛派药业有限公司 | 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 |
CN109045042A (zh) * | 2018-09-21 | 2018-12-21 | 上海交通大学医学院附属上海儿童医学中心 | Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用 |
US20200355997A1 (en) * | 2019-05-08 | 2020-11-12 | Facebook Technologies, Llc | Thianthrene derivatized monomers and polymers for volume bragg gratings |
US11718580B2 (en) | 2019-05-08 | 2023-08-08 | Meta Platforms Technologies, Llc | Fluorene derivatized monomers and polymers for volume Bragg gratings |
US11780819B2 (en) | 2019-11-27 | 2023-10-10 | Meta Platforms Technologies, Llc | Aromatic substituted alkane-core monomers and polymers thereof for volume Bragg gratings |
JP2023539715A (ja) | 2020-06-24 | 2023-09-19 | アストラゼネカ ユーケー リミテッド | 抗体-薬物コンジュゲートとatm阻害剤との組合わせ |
US11879024B1 (en) | 2020-07-14 | 2024-01-23 | Meta Platforms Technologies, Llc | Soft mold formulations for surface relief grating fabrication with imprinting lithography |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1303724A (de) | 1969-05-14 | 1973-01-17 | ||
JPH0753725B2 (ja) | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
US5284856A (en) | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
US5703075A (en) | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
HUT58310A (en) | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
JPH03215423A (ja) | 1990-01-18 | 1991-09-20 | Kyowa Hakko Kogyo Co Ltd | 血管拡張剤 |
AU7998291A (en) | 1990-06-20 | 1992-01-07 | Upjohn Company, The | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
US5302613A (en) | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
US5252735A (en) | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
EP0489877B1 (de) | 1990-06-29 | 1995-09-20 | The Upjohn Company | Antiatherosclerotische und antithrombotische 2-amino-6-phenyl-4h-pyran-4-one |
DE69327153T2 (de) | 1992-09-02 | 2000-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Anti-hiv-medikament |
DE69427907T2 (de) | 1993-04-09 | 2002-04-04 | Toyama Chemical Co. Ltd., Tokio/Tokyo | Immunomodulator, zelladhäsionsinhibitor und mittel zur behandlung und vorbeugung von autoimmunerkrankungen |
US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
US5441947A (en) | 1993-08-25 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting vascular restenosis |
US5468773A (en) | 1993-08-25 | 1995-11-21 | Eli Lilly And Company | Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs |
US5504103A (en) | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
CA2133815A1 (en) | 1993-10-12 | 1995-04-13 | Jeffrey Alan Dodge | Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof |
US6632789B1 (en) | 1994-04-29 | 2003-10-14 | The United States Of America As Represented By The Secretary Of The Navy | Methods for modulating T cell responses by manipulating intracellular signal transduction |
US5480906A (en) | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
GB9521987D0 (en) | 1995-10-26 | 1996-01-03 | Ludwig Inst Cancer Res | Phosphoinositide 3-kinase modulators |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
CN1199420A (zh) | 1995-11-16 | 1998-11-18 | 艾科斯有限公司 | 细胞周期关卡与pik相关的激酶材料和方法 |
GB2302021A (en) | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
AU7953598A (en) | 1997-06-06 | 1998-12-21 | Mayo Foundation For Medical Education And Research | Screening for phosphatidylinositol related-kinase inhibitors |
AU8068198A (en) | 1997-06-13 | 1998-12-30 | President And Fellows Of Harvard College | Methods for treating human cancers |
FR2776291B1 (fr) | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
US6387640B1 (en) | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
US6348311B1 (en) | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
US6333180B1 (en) * | 1999-12-21 | 2001-12-25 | International Flavors & Fragrances Inc. | Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate |
DE60128655T2 (de) | 2000-01-24 | 2008-02-07 | Astrazeneca Ab | Durch einen morpholinrest substituierte therapeutische verbindungen |
SK862003A3 (en) * | 2000-06-28 | 2003-06-03 | Teva Pharma | Carvedilol |
EP1351946A2 (de) | 2000-09-01 | 2003-10-15 | Icos Corporation | Materialien und methoden für krebs-therapie |
DE60203260T2 (de) | 2001-01-16 | 2006-02-02 | Glaxo Group Ltd., Greenford | Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs |
GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
WO2003034997A2 (en) | 2001-10-24 | 2003-05-01 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
AU2002349912A1 (en) | 2001-10-24 | 2003-05-06 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
AU2003209990B8 (en) * | 2002-02-25 | 2008-10-30 | Kudos Pharmaceuticals Ltd | Pyranones useful as ATM inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
AU2003229953A1 (en) | 2002-04-30 | 2003-11-17 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
DE602004026071D1 (de) * | 2003-08-13 | 2010-04-29 | Kudos Pharm Ltd | Aminopyrone und ihre verwendung als atm inhibitoren |
UA88329C2 (en) * | 2004-09-20 | 2009-10-12 | Кудос Фармасьютикалз Лимитед | Dna-pk inhibitors |
JP2008529995A (ja) | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Atm阻害剤 |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
-
2004
- 2004-08-13 DE DE602004026071T patent/DE602004026071D1/de not_active Expired - Lifetime
- 2004-08-13 MX MXPA06001599A patent/MXPA06001599A/es active IP Right Grant
- 2004-08-13 BR BRPI0413467-2A patent/BRPI0413467A/pt not_active IP Right Cessation
- 2004-08-13 EP EP04768070A patent/EP1654257B1/de not_active Expired - Lifetime
- 2004-08-13 GB GB0604321A patent/GB2420781B/en not_active Expired - Fee Related
- 2004-08-13 CA CA002534300A patent/CA2534300A1/en not_active Abandoned
- 2004-08-13 ES ES04768070T patent/ES2341342T3/es not_active Expired - Lifetime
- 2004-08-13 AU AU2004265149A patent/AU2004265149A1/en not_active Abandoned
- 2004-08-13 TW TW093124420A patent/TW200524924A/zh unknown
- 2004-08-13 US US10/918,180 patent/US7429660B2/en not_active Expired - Fee Related
- 2004-08-13 JP JP2006523057A patent/JP2007501836A/ja active Pending
- 2004-08-13 NZ NZ545919A patent/NZ545919A/en unknown
- 2004-08-13 AT AT04768070T patent/ATE461193T1/de not_active IP Right Cessation
- 2004-08-13 CN CN2004800299408A patent/CN1867566B/zh not_active Expired - Fee Related
- 2004-08-13 WO PCT/GB2004/003507 patent/WO2005016919A1/en active Application Filing
- 2004-08-13 KR KR1020067002998A patent/KR20060066722A/ko not_active Application Discontinuation
-
2006
- 2006-02-23 ZA ZA200601595A patent/ZA200601595B/xx unknown
- 2006-03-08 NO NO20061126A patent/NO20061126L/no not_active Application Discontinuation
-
2007
- 2007-05-08 HK HK07104900.4A patent/HK1097273A1/xx not_active IP Right Cessation
-
2008
- 2008-09-19 US US12/233,736 patent/US20090043091A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ545919A (en) | 2009-07-31 |
DE602004026071D1 (de) | 2010-04-29 |
US20090043091A1 (en) | 2009-02-12 |
KR20060066722A (ko) | 2006-06-16 |
TW200524924A (en) | 2005-08-01 |
US7429660B2 (en) | 2008-09-30 |
EP1654257B1 (de) | 2010-03-17 |
WO2005016919A1 (en) | 2005-02-24 |
US20050054657A1 (en) | 2005-03-10 |
MXPA06001599A (es) | 2006-05-19 |
ES2341342T3 (es) | 2010-06-18 |
BRPI0413467A (pt) | 2006-10-17 |
AU2004265149A1 (en) | 2005-02-24 |
GB2420781A (en) | 2006-06-07 |
GB2420781B (en) | 2008-07-09 |
EP1654257A1 (de) | 2006-05-10 |
GB0604321D0 (en) | 2006-04-12 |
CN1867566B (zh) | 2010-06-16 |
NO20061126L (no) | 2006-05-09 |
HK1097273A1 (en) | 2007-06-22 |
CN1867566A (zh) | 2006-11-22 |
JP2007501836A (ja) | 2007-02-01 |
ATE461193T1 (de) | 2010-04-15 |
CA2534300A1 (en) | 2005-02-24 |
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