ZA200601291B - Recombinant lubricin molecules and uses thereof - Google Patents

Recombinant lubricin molecules and uses thereof

Info

Publication number
ZA200601291B
ZA200601291B ZA200601291A ZA200601291A ZA200601291B ZA 200601291 B ZA200601291 B ZA 200601291B ZA 200601291 A ZA200601291 A ZA 200601291A ZA 200601291 A ZA200601291 A ZA 200601291A ZA 200601291 B ZA200601291 B ZA 200601291B
Authority
ZA
South Africa
Prior art keywords
recombinant lubricin
lubricin molecules
molecules
recombinant
lubricin
Prior art date
Application number
ZA200601291A
Other languages
English (en)
Inventor
Carl Ralph Flannery
Bethany Annis Freeman
Christopher John Corcoran
Lisa Anne Racie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200601291B publication Critical patent/ZA200601291B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200601291A 2003-08-14 2006-02-13 Recombinant lubricin molecules and uses thereof ZA200601291B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49574103P 2003-08-14 2003-08-14

Publications (1)

Publication Number Publication Date
ZA200601291B true ZA200601291B (en) 2010-08-25

Family

ID=34193342

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200601291A ZA200601291B (en) 2003-08-14 2006-02-13 Recombinant lubricin molecules and uses thereof

Country Status (21)

Country Link
US (6) US7642236B2 (fr)
EP (1) EP1663291B1 (fr)
JP (1) JP2007502122A (fr)
KR (1) KR101078202B1 (fr)
CN (2) CN1867350A (fr)
AU (2) AU2004264970B2 (fr)
BR (1) BRPI0413553A (fr)
CR (1) CR8204A (fr)
DK (1) DK1663291T3 (fr)
EC (1) ECSP066364A (fr)
ES (1) ES2388970T3 (fr)
HK (1) HK1089110A1 (fr)
IL (2) IL173258A (fr)
MX (1) MXPA06001658A (fr)
NO (1) NO20060475L (fr)
NZ (1) NZ545021A (fr)
RU (2) RU2376313C2 (fr)
SG (1) SG145724A1 (fr)
UA (1) UA91818C2 (fr)
WO (1) WO2005016130A2 (fr)
ZA (1) ZA200601291B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
CA2575086A1 (fr) * 2004-07-23 2006-02-02 Mucosal Therapeutics Llc Compositions et procedes de viscosupplementation
US20090068247A1 (en) * 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) * 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
US8506944B2 (en) 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
CA2722913C (fr) * 2008-05-07 2018-02-27 Schepens Eye Research Institute Compositions de prg4 et methodes de traitement therapeutique des yeux secs
ES2534082T3 (es) * 2009-01-13 2015-04-17 Lubris Llc Modulación terapéutica de la lubricación del límite del epitelio vaginal
WO2010135736A2 (fr) * 2009-05-22 2010-11-25 Singularis Inc. Application, utilisations et modulation thérapeutique de prg4
WO2011091000A2 (fr) * 2010-01-19 2011-07-28 Singularis, Inc. Compositions et procédés destinés à l'hygiène buccale
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US20130116186A1 (en) * 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
US20150361452A1 (en) * 2013-01-25 2015-12-17 Baylor College Of Medicine A Helper-Dependent Adenoviral Gene Therapy Delivery and Expression System
US20150010606A1 (en) * 2013-07-08 2015-01-08 Arthrex, Inc. Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase
WO2015057993A1 (fr) * 2013-10-16 2015-04-23 Ensisheim Partners Llc Formulations spécifiques aux protéines
US9982027B2 (en) * 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
JP6571101B2 (ja) 2013-11-26 2019-09-04 ルブリス，エルエルシー． 細胞間相互作用を阻害するための組成物及び方法
AU2016211694B2 (en) * 2015-01-26 2021-11-11 Lubris Llc Use of PRG4 as an anti-inflammatory agent
HUE051774T2 (hu) 2016-01-13 2021-03-29 Genzyme Corp Oszteoprotektív géneket, például HAS2-t és lubricint expresszáló rekombináns AAV vektorok, amelyek alkalmazhatók emlõsben oszteoartritisz és azzal kapcsolatos ízületi állapotok kezelésében
JP6937309B2 (ja) 2016-01-27 2021-09-22 ジャスト−エヴォテック バイオロジックス、インコーポレイテッド ハイブリッドプロモーターおよびその使用
MX2020013869A (es) * 2018-06-21 2021-03-02 Lubris Llc Lubricina para uso en curacion de heridas referencia cruzada con solicitudes relacionadas.
CN113573724A (zh) * 2019-01-15 2021-10-29 康奈尔大学 重组润滑素和组合物以及其使用方法
AU2021227771A1 (en) * 2020-02-24 2022-10-06 Novartis Ag Purification of recombinantly produced polypeptides
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”

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US2734862A (en) * 1956-02-14 Synthetic casein fiber elastic grease
US2487377A (en) * 1948-04-17 1949-11-08 Socony Vacuum Oil Co Inc Lubricant
US2878184A (en) * 1953-12-29 1959-03-17 Rockwell Mfg Co Hydrocarbon resistant glycerol base lubricant
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
EP0050644B1 (fr) * 1980-04-25 1985-09-18 A/S Orthana Kemisk Fabrik Solutions sterilisees, preservees, stables, et contenant de la mucine et procede de sterilisation
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5260417A (en) * 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
US6433142B1 (en) 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
AU652022B2 (en) * 1991-02-12 1994-08-11 C.R. Bard Inc. Injectable medical device
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
CN1107891A (zh) * 1994-03-04 1995-09-06 上海贝特生物技术有限公司 人促巨核细胞生成素及其分离纯化和基因克隆方法及应用
US5515590A (en) * 1994-07-19 1996-05-14 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5709020A (en) * 1994-07-19 1998-01-20 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5510122A (en) * 1994-09-28 1996-04-23 The Research Foundation Of State University Of New York Preparation and use of whole saliva
US7001881B1 (en) * 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
US6960562B2 (en) * 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
WO2001007068A1 (fr) * 1999-07-23 2001-02-01 Case Western Reserve University Nouveaux procedes et reactifs destines au traitement de l'arthrose
US20030180948A1 (en) * 2000-12-29 2003-09-25 Hutchins Jeff T. Superficial zone protein and methods of making and using same
EP1440981A3 (fr) * 2003-01-21 2005-11-23 Research Association for Biotechnology ADN complementaire humaine de pleine longueur

Also Published As

Publication number Publication date
US20070191268A1 (en) 2007-08-16
DK1663291T3 (da) 2012-07-02
US7893029B2 (en) 2011-02-22
RU2009130434A (ru) 2011-02-20
WO2005016130A2 (fr) 2005-02-24
US7642236B2 (en) 2010-01-05
KR101078202B1 (ko) 2011-11-01
US7897571B2 (en) 2011-03-01
US20110189731A1 (en) 2011-08-04
CN102924584A (zh) 2013-02-13
KR20060072124A (ko) 2006-06-27
US8420793B2 (en) 2013-04-16
US20150343019A1 (en) 2015-12-03
RU2006107925A (ru) 2006-07-27
JP2007502122A (ja) 2007-02-08
AU2004264970A1 (en) 2005-02-24
AU2010201537B2 (en) 2012-02-23
US8987205B2 (en) 2015-03-24
NZ545021A (en) 2009-03-31
SG145724A1 (en) 2008-09-29
NO20060475L (no) 2006-03-13
EP1663291B1 (fr) 2012-06-06
EP1663291A2 (fr) 2006-06-07
US20100074935A1 (en) 2010-03-25
AU2004264970B2 (en) 2010-02-11
HK1089110A1 (en) 2006-11-24
IL173258A0 (en) 2006-06-11
IL173258A (en) 2010-12-30
CN1867350A (zh) 2006-11-22
AU2010201537A1 (en) 2010-05-06
UA91818C2 (ru) 2010-09-10
EP1663291A4 (fr) 2009-08-05
RU2376313C2 (ru) 2009-12-20
IL199528A (en) 2013-03-24
ECSP066364A (es) 2006-08-30
ES2388970T3 (es) 2012-10-22
WO2005016130A3 (fr) 2006-02-02
IL199528A0 (en) 2011-08-01
BRPI0413553A (pt) 2006-10-17
US20100080848A1 (en) 2010-04-01
CR8204A (es) 2007-10-01
US20130196930A1 (en) 2013-08-01
MXPA06001658A (es) 2006-04-28

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