ZA200509294B - Benzothiazole derivatives as adenosine receptor ligands - Google Patents
Benzothiazole derivatives as adenosine receptor ligands Download PDFInfo
- Publication number
- ZA200509294B ZA200509294B ZA200509294A ZA200509294A ZA200509294B ZA 200509294 B ZA200509294 B ZA 200509294B ZA 200509294 A ZA200509294 A ZA 200509294A ZA 200509294 A ZA200509294 A ZA 200509294A ZA 200509294 B ZA200509294 B ZA 200509294B
- Authority
- ZA
- South Africa
- Prior art keywords
- methoxy
- benzothiazol
- tetrahydro
- dioxepan
- pyran
- Prior art date
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- 102000009346 Adenosine receptors Human genes 0.000 title claims description 14
- 108050000203 Adenosine receptors Proteins 0.000 title claims description 14
- 239000003446 ligand Substances 0.000 title description 5
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title description 2
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- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 53
- 125000000217 alkyl group Chemical group 0.000 claims description 38
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 28
- 229960005305 adenosine Drugs 0.000 claims description 28
- -1 1,4-dioxepanyl Chemical group 0.000 claims description 26
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- 125000001424 substituent group Chemical group 0.000 claims description 6
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- Physical Education & Sports Medicine (AREA)
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| EP03011039 | 2003-05-19 |
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| EP (1) | EP1636223B1 (de) |
| JP (1) | JP4444290B2 (de) |
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| CN (1) | CN100528871C (de) |
| AR (1) | AR044362A1 (de) |
| AT (1) | ATE389652T1 (de) |
| AU (1) | AU2004251814B2 (de) |
| BR (1) | BRPI0410440A (de) |
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| CL (1) | CL2004001067A1 (de) |
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| HR (1) | HRP20080207T3 (de) |
| IL (1) | IL171686A (de) |
| MX (1) | MXPA05012360A (de) |
| NO (1) | NO20055150L (de) |
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| PL (1) | PL1636223T3 (de) |
| PT (1) | PT1636223E (de) |
| RU (1) | RU2351597C2 (de) |
| SI (1) | SI1636223T1 (de) |
| TW (1) | TW200505882A (de) |
| WO (1) | WO2005000842A1 (de) |
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| WO2008052930A2 (en) * | 2006-11-03 | 2008-05-08 | F. Hoffmann-La Roche Ag | Preparation of 4-alk0xy-7- (tetrahydropyran-4-yl) benzothiazol-2-amine derivatives |
| SI3661941T1 (sl) * | 2017-08-01 | 2023-04-28 | Merck Patent Gmbh | Tiazolopiridinski derivati kot antagonisti adenozinskih receptorjev |
| DK3672951T3 (da) * | 2017-08-21 | 2023-11-20 | Merck Patent Gmbh | Quinoxalinderivater som adenosinreceptorantagonister |
| TWI791593B (zh) * | 2017-08-21 | 2023-02-11 | 德商馬克專利公司 | 做為腺苷受體拮抗劑之苯并咪唑衍生物 |
| WO2019141096A1 (zh) * | 2018-01-19 | 2019-07-25 | 四川科伦博泰生物医药股份有限公司 | 取代脲类化合物及其制备方法和用途 |
| MX2021003901A (es) | 2018-10-25 | 2021-06-04 | Merck Patent Gmbh | Derivados de 5-azaindazol como antagonistas del receptor de adenosina. |
| WO2020083856A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
| AR117844A1 (es) | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1303272B1 (de) * | 2000-06-21 | 2008-02-13 | F. Hoffmann-La Roche Ag | Benzothiazolderivate zur behandlung von alzheimer und parkinson |
| BR0214455A (pt) * | 2001-11-27 | 2004-11-03 | Hoffmann La Roche | Derivados benzotiazol |
| US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| ATE388945T1 (de) * | 2003-01-13 | 2008-03-15 | Hoffmann La Roche | Benzoxazolderivate und deren verwendung als adenosinrezeptorliganden |
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2004
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- 2004-05-14 DK DK04732950T patent/DK1636223T3/da active
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- 2004-05-14 ES ES04732950T patent/ES2301991T3/es not_active Expired - Lifetime
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- 2004-05-14 SI SI200430668T patent/SI1636223T1/sl unknown
- 2004-05-14 TW TW093113590A patent/TW200505882A/zh unknown
- 2004-05-14 PT PT04732950T patent/PT1636223E/pt unknown
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2005
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- 2005-11-16 CO CO05116289A patent/CO5630031A2/es not_active Application Discontinuation
- 2005-11-16 ZA ZA200509294A patent/ZA200509294B/en unknown
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2006
- 2006-11-29 HK HK06113066.6A patent/HK1092469A1/xx not_active IP Right Cessation
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2008
- 2008-05-08 HR HR20080207T patent/HRP20080207T3/xx unknown
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