ZA200505517B - Alphavirus particles and methods for preparation - Google Patents

Alphavirus particles and methods for preparation Download PDF

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Publication number
ZA200505517B
ZA200505517B ZA200505517A ZA200505517A ZA200505517B ZA 200505517 B ZA200505517 B ZA 200505517B ZA 200505517 A ZA200505517 A ZA 200505517A ZA 200505517 A ZA200505517 A ZA 200505517A ZA 200505517 B ZA200505517 B ZA 200505517B
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ZA
South Africa
Prior art keywords
alphavirus
cells
helper
nucleic acid
replicon
Prior art date
Application number
ZA200505517A
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English (en)
Inventor
Jonathan F Smith
Kurt Kamrud
Sergey Dryga
Harold Alterson
Jon Rayner
Kim Butler
Maureen F Maughan
Original Assignee
Alphavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphavax Inc filed Critical Alphavax Inc
Publication of ZA200505517B publication Critical patent/ZA200505517B/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36151Methods of production or purification of viral material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36161Methods of inactivation or attenuation
    • C12N2770/36162Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA200505517A 2002-12-13 2006-01-24 Alphavirus particles and methods for preparation ZA200505517B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43305802P 2002-12-13 2002-12-13

Publications (1)

Publication Number Publication Date
ZA200505517B true ZA200505517B (en) 2006-03-29

Family

ID=32595112

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200505517A ZA200505517B (en) 2002-12-13 2006-01-24 Alphavirus particles and methods for preparation

Country Status (13)

Country Link
US (1) US7078218B2 (pt)
EP (3) EP3246399B1 (pt)
JP (2) JP5079981B2 (pt)
AU (1) AU2003297041B2 (pt)
BR (2) BRPI0317276B8 (pt)
CA (2) CA2509979C (pt)
DK (3) DK3246399T3 (pt)
ES (3) ES2630222T3 (pt)
HK (1) HK1082524A1 (pt)
IL (1) IL169076A (pt)
NZ (1) NZ540657A (pt)
WO (1) WO2004055167A2 (pt)
ZA (1) ZA200505517B (pt)

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EP1651666B1 (en) 2003-07-11 2009-05-27 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
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US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
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Also Published As

Publication number Publication date
AU2003297041A1 (en) 2004-07-09
ES2630222T3 (es) 2017-08-18
EP2290054A1 (en) 2011-03-02
HK1082524A1 (zh) 2006-06-09
NZ540657A (en) 2006-09-29
EP1590451B1 (en) 2015-09-16
BRPI0317276B8 (pt) 2021-05-25
US20040166573A1 (en) 2004-08-26
CA2509979A1 (en) 2004-07-01
BR0317276A (pt) 2005-11-08
EP3246399B1 (en) 2021-07-07
AU2003297041B2 (en) 2009-02-26
DK3246399T3 (da) 2021-10-04
EP2290054B1 (en) 2017-03-29
BRPI0317276B1 (pt) 2020-09-15
CA2509979C (en) 2013-02-26
EP3246399A1 (en) 2017-11-22
JP2006509524A (ja) 2006-03-23
ES2552687T3 (es) 2015-12-01
JP5727420B2 (ja) 2015-06-03
ES2890023T3 (es) 2022-01-17
US7078218B2 (en) 2006-07-18
DK2290054T3 (en) 2017-07-03
WO2004055167A2 (en) 2004-07-01
CA2807515C (en) 2014-02-04
EP1590451A2 (en) 2005-11-02
IL169076A (en) 2010-05-31
WO2004055167A3 (en) 2005-01-13
JP2012210224A (ja) 2012-11-01
EP1590451A4 (en) 2007-05-02
CA2807515A1 (en) 2004-07-01
JP5079981B2 (ja) 2012-11-21
BR122019005271B1 (pt) 2020-10-13
DK1590451T3 (en) 2015-12-14

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