ZA200504175B - Methylene urea derivatives as raf-kinase inhibitors - Google Patents

Methylene urea derivatives as raf-kinase inhibitors Download PDF

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Publication number
ZA200504175B
ZA200504175B ZA200504175A ZA200504175A ZA200504175B ZA 200504175 B ZA200504175 B ZA 200504175B ZA 200504175 A ZA200504175 A ZA 200504175A ZA 200504175 A ZA200504175 A ZA 200504175A ZA 200504175 B ZA200504175 B ZA 200504175B
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South Africa
Prior art keywords
group
substituted
carbon atoms
cancer
halogen
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ZA200504175A
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English (en)
Inventor
Hans-Peter Buchstaller
Oliver Schadt
Frank Zenke
Matthias Grell
Matthias Wiesner
Christiane Amendt
Christian Sirrenberg
Dirk Finsinger
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Merck Patent Gmbh
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Publication of ZA200504175B publication Critical patent/ZA200504175B/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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ZA200504175A 2002-10-24 2006-01-17 Methylene urea derivatives as raf-kinase inhibitors ZA200504175B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02023906 2002-10-24

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ZA200504175B true ZA200504175B (en) 2006-03-29

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ID=35578185

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ZA200504175A ZA200504175B (en) 2002-10-24 2006-01-17 Methylene urea derivatives as raf-kinase inhibitors

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US (3) US7589112B2 (ru)
EP (1) EP1562905A2 (ru)
JP (2) JP4690889B2 (ru)
KR (1) KR20050071598A (ru)
CN (1) CN1705645A (ru)
AR (1) AR041719A1 (ru)
AU (1) AU2003268926B2 (ru)
BR (1) BR0315580A (ru)
CA (1) CA2503445C (ru)
MX (1) MXPA05004206A (ru)
PL (1) PL374758A1 (ru)
RU (1) RU2005115842A (ru)
WO (1) WO2004037789A2 (ru)
ZA (1) ZA200504175B (ru)

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US9296697B2 (en) 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
WO2007063868A1 (ja) * 2005-11-29 2007-06-07 Toray Industries, Inc. アリールメチレンウレア誘導体及びその用途
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US8569308B2 (en) * 2009-09-17 2013-10-29 Vanderbilt University Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
CN102408426B (zh) * 2011-09-14 2013-07-10 湖南有色凯铂生物药业有限公司 取代的芳香脲类化合物及其作为抗癌药物的应用
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RU2005115842A (ru) 2006-03-10
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CN1705645A (zh) 2005-12-07
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