ZA200504003B - Treatment of huntington's disease with EPA - Google Patents
Treatment of huntington's disease with EPA Download PDFInfo
- Publication number
- ZA200504003B ZA200504003B ZA200504003A ZA200504003A ZA200504003B ZA 200504003 B ZA200504003 B ZA 200504003B ZA 200504003 A ZA200504003 A ZA 200504003A ZA 200504003 A ZA200504003 A ZA 200504003A ZA 200504003 B ZA200504003 B ZA 200504003B
- Authority
- ZA
- South Africa
- Prior art keywords
- epa
- patients
- disease
- huntington
- ethyl
- Prior art date
Links
- 208000023105 Huntington disease Diseases 0.000 title claims abstract description 35
- 238000011282 treatment Methods 0.000 title claims abstract description 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- 208000024891 symptom Diseases 0.000 claims description 7
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract description 43
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract description 40
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract description 39
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract description 39
- 238000004458 analytical method Methods 0.000 abstract description 4
- 239000000902 placebo Substances 0.000 description 13
- 229940068196 placebo Drugs 0.000 description 13
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 5
- -1 ethyl- Chemical group 0.000 description 5
- 230000005856 abnormality Effects 0.000 description 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 210000003140 lateral ventricle Anatomy 0.000 description 3
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 208000015122 neurodegenerative disease Diseases 0.000 description 3
- 229920000155 polyglutamine Polymers 0.000 description 3
- 108010040003 polyglutamine Proteins 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 2
- 208000016285 Movement disease Diseases 0.000 description 2
- 210000005013 brain tissue Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 125000000404 glutamine group Chemical class N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 206010054196 Affect lability Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 description 1
- 230000002932 anti-schizophrenic effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000003693 atypical antipsychotic agent Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 201000004559 cerebral degeneration Diseases 0.000 description 1
- 210000004720 cerebrum Anatomy 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960004170 clozapine Drugs 0.000 description 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 229940066279 eicosapentaenoate Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 235000004554 glutamine Nutrition 0.000 description 1
- 229960003878 haloperidol Drugs 0.000 description 1
- 101150113725 hd gene Proteins 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229960000652 sertindole Drugs 0.000 description 1
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0228079.0A GB0228079D0 (en) | 2002-12-02 | 2002-12-02 | Huntington's Disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200504003B true ZA200504003B (en) | 2007-01-31 |
Family
ID=9948921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200504003A ZA200504003B (en) | 2002-12-02 | 2005-05-18 | Treatment of huntington's disease with EPA |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20070148643A1 (ru) |
| EP (1) | EP1567667B1 (ru) |
| JP (1) | JP2006507833A (ru) |
| KR (1) | KR20050086895A (ru) |
| CN (1) | CN1717497A (ru) |
| AT (1) | ATE411399T1 (ru) |
| AU (1) | AU2003285519A1 (ru) |
| BR (1) | BR0316969A (ru) |
| CA (1) | CA2506727A1 (ru) |
| CY (1) | CY1108730T1 (ru) |
| DE (1) | DE60324180D1 (ru) |
| DK (1) | DK1567667T3 (ru) |
| ES (1) | ES2315543T3 (ru) |
| GB (1) | GB0228079D0 (ru) |
| HK (1) | HK1081598A1 (ru) |
| HR (1) | HRP20050493A2 (ru) |
| IS (1) | IS7842A (ru) |
| MX (1) | MXPA05005908A (ru) |
| MY (1) | MY138759A (ru) |
| NO (1) | NO20052955L (ru) |
| NZ (1) | NZ539989A (ru) |
| PL (1) | PL376101A1 (ru) |
| PT (1) | PT1567667E (ru) |
| RU (1) | RU2332209C2 (ru) |
| SI (1) | SI1567667T1 (ru) |
| TW (1) | TWI306120B (ru) |
| UA (1) | UA86582C2 (ru) |
| WO (1) | WO2004050913A1 (ru) |
| ZA (1) | ZA200504003B (ru) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2551882A1 (en) * | 2004-01-19 | 2005-08-11 | Martek Biosciences Corporation | Reelin deficiency or dysfunction and methods related thereto |
| WO2007123391A1 (en) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| NZ574807A (en) | 2006-08-11 | 2011-01-28 | Prosensa Technologies Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| CN103212085A (zh) | 2007-07-12 | 2013-07-24 | 普罗森那技术公司 | 用于使化合物靶向多种选定器官或组织的分子 |
| EP2167135A2 (en) | 2007-07-12 | 2010-03-31 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| CN101896186A (zh) | 2007-10-26 | 2010-11-24 | 莱顿教学医院 | 对抗肌肉病症的方式和方法 |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| WO2009099326A1 (en) | 2008-02-08 | 2009-08-13 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| EP3578177A1 (en) | 2008-09-02 | 2019-12-11 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| EP2596786B1 (en) | 2009-02-10 | 2019-11-27 | Amarin Pharmaceuticals Ireland Limited | Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia |
| ES2593836T3 (es) | 2009-04-24 | 2016-12-13 | Biomarin Technologies B.V. | Oligonucleótido que comprende una inosina para tratar la DMD |
| RU2538691C2 (ru) | 2009-04-29 | 2015-01-10 | Амарин Фарма, Инк. | Стабильные фармацевтические композиции и способы их применения |
| EP3563842A1 (en) | 2009-04-29 | 2019-11-06 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| LT3318255T (lt) | 2009-06-15 | 2021-05-25 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti insulto gydymui pacientui kartu su statinų terapija |
| CA2775339C (en) | 2009-09-23 | 2017-03-28 | Amarin Corporation Plc | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| AU2010335039B2 (en) | 2009-12-24 | 2015-03-26 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Molecule for treating an inflammatory disorder |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| NZ744990A (en) | 2010-11-29 | 2019-10-25 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| EP2775837A4 (en) | 2011-11-07 | 2015-10-28 | Amarin Pharmaceuticals Ie Ltd | METHODS OF TREATING HYPERTRIGLYCERIDEMIA |
| EP2800469B1 (en) | 2012-01-06 | 2021-08-25 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| EP4043039A1 (en) | 2012-01-27 | 2022-08-17 | BioMarin Technologies B.V. | Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy |
| EP4342546A3 (en) | 2012-06-29 | 2024-05-22 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| TW201900160A (zh) | 2017-05-19 | 2019-01-01 | 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 | 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法 |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| FI4056176T3 (fi) | 2018-09-24 | 2024-05-30 | Amarin Pharmaceuticals Ie Ltd | Menetelmät kardiovaskulaaristen tapahtumien riskin pienentämiseksi tutkittavassa |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2116280A1 (en) * | 1993-03-05 | 1994-09-06 | Marcy E. Macdonald | Huntingtin dna, protein and uses thereof |
| CA2216057A1 (en) * | 1997-09-19 | 1999-03-19 | Ridha Joober | Polymorphic cag repeat-containing gene, diagnosis of psychiatric diseases and therapeutic uses thereof |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| WO2001024781A2 (en) * | 1999-10-07 | 2001-04-12 | Novaneuron Inc. | Gene necessary for striatal function, uses thereof, and compounds for modulating same |
-
2002
- 2002-12-02 GB GBGB0228079.0A patent/GB0228079D0/en not_active Ceased
-
2003
- 2003-11-21 MY MYPI20034492A patent/MY138759A/en unknown
- 2003-11-26 DK DK03778516T patent/DK1567667T3/da active
- 2003-11-26 DE DE60324180T patent/DE60324180D1/de not_active Expired - Lifetime
- 2003-11-26 UA UAA200505201A patent/UA86582C2/ru unknown
- 2003-11-26 TW TW092133160A patent/TWI306120B/zh active
- 2003-11-26 PT PT03778516T patent/PT1567667E/pt unknown
- 2003-11-26 BR BR0316969-3A patent/BR0316969A/pt not_active IP Right Cessation
- 2003-11-26 JP JP2004556479A patent/JP2006507833A/ja active Pending
- 2003-11-26 KR KR1020057009802A patent/KR20050086895A/ko not_active Application Discontinuation
- 2003-11-26 AU AU2003285519A patent/AU2003285519A1/en not_active Abandoned
- 2003-11-26 PL PL03376101A patent/PL376101A1/xx unknown
- 2003-11-26 AT AT03778516T patent/ATE411399T1/de not_active IP Right Cessation
- 2003-11-26 EP EP03778516A patent/EP1567667B1/en not_active Expired - Lifetime
- 2003-11-26 CA CA002506727A patent/CA2506727A1/en not_active Abandoned
- 2003-11-26 WO PCT/GB2003/005131 patent/WO2004050913A1/en active Application Filing
- 2003-11-26 RU RU2005115536/14A patent/RU2332209C2/ru not_active IP Right Cessation
- 2003-11-26 SI SI200331472T patent/SI1567667T1/sl unknown
- 2003-11-26 US US10/536,927 patent/US20070148643A1/en not_active Abandoned
- 2003-11-26 ES ES03778516T patent/ES2315543T3/es not_active Expired - Lifetime
- 2003-11-26 NZ NZ539989A patent/NZ539989A/en unknown
- 2003-11-26 CN CNA2003801044204A patent/CN1717497A/zh active Pending
- 2003-11-26 MX MXPA05005908A patent/MXPA05005908A/es active IP Right Grant
-
2005
- 2005-05-12 IS IS7842A patent/IS7842A/is unknown
- 2005-05-18 ZA ZA200504003A patent/ZA200504003B/en unknown
- 2005-06-02 HR HR20050493A patent/HRP20050493A2/xx not_active Application Discontinuation
- 2005-06-16 NO NO20052955A patent/NO20052955L/no not_active Application Discontinuation
-
2006
- 2006-02-02 HK HK06101406A patent/HK1081598A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 CY CY20091100029T patent/CY1108730T1/el unknown
- 2009-04-24 US US12/429,825 patent/US20090270504A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2332209C2 (ru) | 2008-08-27 |
| MY138759A (en) | 2009-07-31 |
| HRP20050493A2 (en) | 2005-10-31 |
| EP1567667A1 (en) | 2005-08-31 |
| DE60324180D1 (de) | 2008-11-27 |
| NO20052955L (no) | 2005-06-16 |
| TW200418993A (en) | 2004-10-01 |
| ES2315543T3 (es) | 2009-04-01 |
| IS7842A (is) | 2005-05-12 |
| WO2004050913A1 (en) | 2004-06-17 |
| TWI306120B (en) | 2009-02-11 |
| GB0228079D0 (en) | 2003-01-08 |
| ATE411399T1 (de) | 2008-10-15 |
| RU2005115536A (ru) | 2006-01-27 |
| UA86582C2 (ru) | 2009-05-12 |
| EP1567667B1 (en) | 2008-10-15 |
| DK1567667T3 (da) | 2009-01-12 |
| CY1108730T1 (el) | 2014-04-09 |
| CA2506727A1 (en) | 2004-06-17 |
| PT1567667E (pt) | 2008-11-04 |
| MXPA05005908A (es) | 2005-12-12 |
| HK1081598A1 (en) | 2006-05-19 |
| US20070148643A1 (en) | 2007-06-28 |
| SI1567667T1 (sl) | 2009-04-30 |
| AU2003285519A1 (en) | 2004-06-23 |
| CN1717497A (zh) | 2006-01-04 |
| JP2006507833A (ja) | 2006-03-09 |
| US20090270504A1 (en) | 2009-10-29 |
| PL376101A1 (en) | 2005-12-12 |
| NZ539989A (en) | 2006-11-30 |
| KR20050086895A (ko) | 2005-08-30 |
| BR0316969A (pt) | 2005-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1567667B1 (en) | Treatment of huntington's disease with epa | |
| US5434170A (en) | Method for treating neurocognitive disorders | |
| Little et al. | A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. | |
| JP2009185067A (ja) | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト | |
| WO2016145193A1 (en) | Lsd for the treatment of alzheimer's disease | |
| AU2013219799B2 (en) | Methods of treating and preventing diseases and disorders of the central nervous system | |
| US20190381049A1 (en) | Compositions and methods for treating dementia | |
| JP2022009066A (ja) | Ｓ－エコールを用いてアルツハイマー病を診断するおよび治療する方法 | |
| Aubourg et al. | Adrenoleukodystrophy presenting as Addison's disease in children and adults | |
| Mayeux | Therapeutic strategies in Alzheimer's disease | |
| CN109562280B (zh) | 复发-缓解型多发性硬化的诊断或预测因子 | |
| Gallagher et al. | Friedreich's ataxia associated with mitochondrial myopathy: clinicopathologic report | |
| WO2014183110A1 (en) | Methods for the detection of brain injury | |
| CN116327778A (zh) | 包含β-羟丁酸盐和维生素D的药物组合物及其用途 | |
| Holt et al. | Hammersmith Hospital, London, 27-29 October 1988 | |
| Carmody et al. | Irish Neurological Association Proceedings of the 23rd Annual Scientific Meeting of the Irish Neurological Association—Galway, 9th–10th October 1987 | |
| NZ611948B2 (en) | Methods and drug products for treating alzheimer's disease |