ZA200502835B - Conjugates of TC complexes and targeting moieties and their use in MRI diagnostic - Google Patents
Conjugates of TC complexes and targeting moieties and their use in MRI diagnostic Download PDFInfo
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- ZA200502835B ZA200502835B ZA200502835A ZA200502835A ZA200502835B ZA 200502835 B ZA200502835 B ZA 200502835B ZA 200502835 A ZA200502835 A ZA 200502835A ZA 200502835 A ZA200502835 A ZA 200502835A ZA 200502835 B ZA200502835 B ZA 200502835B
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- 150000002513 isocyanates Chemical class 0.000 description 1
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- 210000003734 kidney Anatomy 0.000 description 1
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- 238000002386 leaching Methods 0.000 description 1
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- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- ZIQCFMQDHHFGHJ-UHFFFAOYSA-N n-[3-[2-[2-aminoethyl-[2-[(3-hydroxyimino-2-methylbutan-2-yl)amino]ethyl]amino]ethylamino]-3-methylbutan-2-ylidene]hydroxylamine Chemical compound ON=C(C)C(C)(C)NCCN(CCN)CCNC(C)(C)C(C)=NO ZIQCFMQDHHFGHJ-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 239000012038 nucleophile Substances 0.000 description 1
- 229960002700 octreotide Drugs 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000006146 oximation reaction Methods 0.000 description 1
- 125000003544 oxime group Chemical group 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N p-hydroxybenzoic acid propyl ester Natural products CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- IZUPBVBPLAPZRR-UHFFFAOYSA-N pentachloro-phenol Natural products OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IZUPBVBPLAPZRR-UHFFFAOYSA-N 0.000 description 1
- 150000004707 phenolate Chemical class 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical compound [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 description 1
- 229940031826 phenolate Drugs 0.000 description 1
- 239000002530 phenolic antioxidant Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000004713 phosphodiesters Chemical class 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 108010023474 pro-alpha-2-plasmin inhibitor Proteins 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000003608 radiolysis reaction Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 229940013123 stannous chloride Drugs 0.000 description 1
- 229940007163 stannous tartrate Drugs 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012496 stress study Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 150000003556 thioamides Chemical class 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 150000007944 thiolates Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
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- 210000003462 vein Anatomy 0.000 description 1
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- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0224799.7A GB0224799D0 (en) | 2002-10-25 | 2002-10-25 | Improved complex compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200502835B true ZA200502835B (en) | 2006-03-29 |
Family
ID=9946533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200502835A ZA200502835B (en) | 2002-10-25 | 2006-01-19 | Conjugates of TC complexes and targeting moieties and their use in MRI diagnostic |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1553986B1 (fr) |
| JP (1) | JP2006508084A (fr) |
| KR (1) | KR20050070080A (fr) |
| CN (1) | CN1708322A (fr) |
| AT (1) | ATE402720T1 (fr) |
| AU (1) | AU2003279444A1 (fr) |
| BR (1) | BR0315578A (fr) |
| CA (1) | CA2501684A1 (fr) |
| DE (1) | DE60322562D1 (fr) |
| ES (1) | ES2309361T3 (fr) |
| GB (1) | GB0224799D0 (fr) |
| MX (1) | MXPA05004418A (fr) |
| NO (1) | NO20051811L (fr) |
| RU (1) | RU2005110960A (fr) |
| WO (1) | WO2004037297A1 (fr) |
| ZA (1) | ZA200502835B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0515974D0 (en) * | 2005-08-03 | 2005-09-07 | Ge Healthcare Ltd | Compounds and imaging methods |
| GB0520527D0 (en) * | 2005-10-10 | 2005-11-16 | Ge Healthcare Ltd | Automated method |
| GB0614337D0 (en) * | 2006-07-19 | 2006-08-30 | Acal Energy Ltd | Fuel Cells |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| CN107362376A (zh) * | 2010-07-27 | 2017-11-21 | 通用电气健康护理有限公司 | 放射性药物组合物 |
| NZ612151A (en) | 2010-12-21 | 2015-08-28 | Ge Healthcare Ltd | Use of aniline in the radiostabilization of oxime ligation |
| BR112013015869A2 (pt) * | 2010-12-22 | 2017-07-04 | Tfchem | composto, processo para preparar um composto, uso, peptídeo e composição farmacêutica ou cosmética. |
| GB201103696D0 (en) * | 2011-03-04 | 2011-04-20 | Ge Healthcare Ltd | Technetium labelled peptides |
| US20130195756A1 (en) * | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
| GB201610176D0 (en) * | 2016-06-10 | 2016-07-27 | Edinburgh Molecular Imaging Ltd | Imaging agents and methods of use |
| CN112830940B (zh) * | 2020-09-07 | 2022-03-01 | 中国科学院宁波材料技术与工程研究所 | 2,5-呋喃二甲醛肟金属络合物及其制备方法、及在抗菌除霉消毒剂中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999060018A1 (fr) * | 1998-05-15 | 1999-11-25 | Nycomed Amersham Plc | Analogues de glutamine et de lysine marques |
| JP5043271B2 (ja) * | 2000-04-12 | 2012-10-10 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドベースの化合物 |
| EP1283728A2 (fr) * | 2000-05-23 | 2003-02-19 | Amersham Health AS | Agents de contraste |
| NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| GB0105224D0 (en) * | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
-
2002
- 2002-10-25 GB GBGB0224799.7A patent/GB0224799D0/en not_active Ceased
-
2003
- 2003-10-24 AT AT03772392T patent/ATE402720T1/de not_active IP Right Cessation
- 2003-10-24 WO PCT/GB2003/004573 patent/WO2004037297A1/fr active IP Right Grant
- 2003-10-24 AU AU2003279444A patent/AU2003279444A1/en not_active Abandoned
- 2003-10-24 EP EP03772392A patent/EP1553986B1/fr not_active Expired - Lifetime
- 2003-10-24 KR KR1020057006999A patent/KR20050070080A/ko not_active Application Discontinuation
- 2003-10-24 CN CNA2003801020619A patent/CN1708322A/zh active Pending
- 2003-10-24 JP JP2004546174A patent/JP2006508084A/ja not_active Withdrawn
- 2003-10-24 CA CA002501684A patent/CA2501684A1/fr not_active Abandoned
- 2003-10-24 BR BR0315578-1A patent/BR0315578A/pt not_active IP Right Cessation
- 2003-10-24 ES ES03772392T patent/ES2309361T3/es not_active Expired - Lifetime
- 2003-10-24 RU RU2005110960/15A patent/RU2005110960A/ru not_active Application Discontinuation
- 2003-10-24 DE DE60322562T patent/DE60322562D1/de not_active Expired - Lifetime
- 2003-10-24 MX MXPA05004418A patent/MXPA05004418A/es not_active Application Discontinuation
-
2005
- 2005-04-14 NO NO20051811A patent/NO20051811L/no not_active Application Discontinuation
-
2006
- 2006-01-19 ZA ZA200502835A patent/ZA200502835B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0224799D0 (en) | 2002-12-04 |
| MXPA05004418A (es) | 2005-11-23 |
| WO2004037297A1 (fr) | 2004-05-06 |
| NO20051811D0 (no) | 2005-04-14 |
| ATE402720T1 (de) | 2008-08-15 |
| BR0315578A (pt) | 2005-10-25 |
| CA2501684A1 (fr) | 2004-05-06 |
| JP2006508084A (ja) | 2006-03-09 |
| EP1553986A1 (fr) | 2005-07-20 |
| NO20051811L (no) | 2005-06-27 |
| AU2003279444A1 (en) | 2004-05-13 |
| DE60322562D1 (de) | 2008-09-11 |
| CN1708322A (zh) | 2005-12-14 |
| ES2309361T3 (es) | 2008-12-16 |
| KR20050070080A (ko) | 2005-07-05 |
| EP1553986B1 (fr) | 2008-07-30 |
| RU2005110960A (ru) | 2005-11-20 |
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